21 research outputs found

    Review on Phytopharmacological Activity of Curcuma amada Roxb. (Mango ginger)

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    Plants have been an essential part of our daily lives since early advancement. Since prehistoric times, they’vebeen found and employed in traditional medicine. The plant has been used as a medication for diseases and disorders. Curcuma amada Roxb. (Mango ginger) of the family Zingiberaceae belongs to the genus Curcuma, a beneficial plant in the indigenous system of medicine. It has a significant role in food as well as in pharmaceuticals. Some of its outstanding medical characteristics, including antioxidant, antiviral, antibacterial and anti-inflammatory properties, have been reported. Dermatological issues like eczema, itching, and digestive problems are treated with rhizomes. The plant parts are rich in starch, phenolic acids, curcuminoids, volatile oils, minerals, vitamins and phytoconstituents like labdane diterpene dialdehyde, amadaldehyde, zederone, amadannulen, difurocumenonol. C. amada is used in Ayurveda and Unani medical systems as an aphrodisiac, expectorant, appetizer, diuretic, emollient, antipyretic as well as to treat asthma, skin ailments, itching, biliousness, bronchitis, hiccough, and inflammation caused by accidents. This research focused on the main active ingredients, their biological activities and therapeutic capabilities, traditional use and proven pharmacological aspects that may be important from a pharmacological standpoint

    Comparative Analysis of Mechanical and Water Absorption Properties of Nano/micro-sized Alumina Filler Based Glass-Jute Hybrid Composites

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    In recent years, the addition of nano and micro size filler material for fabricating composite materials are emerging concept through which mechanical properties of the composite can be enhanced. Filler based hybrid polymer composite materials are substituting metallic materials because of their low specific wear rate, high specific strength modulus, and less water absorption. In current work, nano and micro Al2O3 filler based Glass-Jute hybrid composite have been fabricated to study the mechanical properties like hardness, impact test, specific wear rate, and flexural strength for each type of composite sample. Water absorption analysis is also carried under three different fluid media namely normal water, river water and de-ionized water-based Al2O3 nanofluid. Nano filler enriched composite attributed the higher magnitudes of hardness, impact strength, flexural strength and lower value of specific wear rate and water absorption compared to micro and normal composites. However, a nanofiller based composite is more suitable for automotive, aerospace and ship manufacturing industries

    Bovine Mastitis: Causes and Phytoremedies

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    Mastitis is a highly frequent chronic ailment with inflammation in the udder of the milking cows. The causative agents are mostly microbes. It is economically prominent contamination of lactating cows resulting in reduced milk production. The disease is diagnosed by chemical, physical and nutritional changes in the milk and pathological changes in the milk glands. Prevention measures for the disease can be taken by proper and timely sanitation of the cowshed through and time again disinfection of the teat, mechanized milking process, etc. The application of bactericidal drugs generates resistant varieties of microbes that cross the allopathic boundary. In this regard, an attempt is taken to focus the plant-based pharmacopoeia. Medicinal plants are traditionally used to cure various diseases as they are comparatively accessible to administer orally in different forms and can be along with fodder. Keeping the above facts in view, the present review deals with different types of mastitis, causative pathogens, detection and diagnosis, and effective plant-based treatment process available to date

    Recent Advancements in Phyto Component Based Nanocarriers for Improved Treatment of Brain Disorders

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    Effective treatment of brain disorders remains a tough task in medical science. Age-old brain disorders like Parkinson’s (PD) and Alzheimer’s (AD) are yet to be managed effectively in spite of fabulous scientific progress over the last decades. Presently available treatment strategies have been found insufficient to tackle the out bursting cases of AD and PD. Indeed, presence of blood-brain barrier (BBB) highly hijacks success of conventional drug therapy. In this regard, phyto bioactive components delivered through nanocarrier (NCs) systems hold ray of hope in improving treatment benefits in brain disorders. Several NCs including polymeric nanoparticles, nanoliposomes, micelles, dendrimers have now being heavily researched to effectively deliver the phyto active components to brain tissue. NCs owing to their structural and physiological uniqueness have now been evolved with great potential for the treatment of brain disorders. Functionalization of brain specific ligands on the surface of NCs further makes them target specific, which might significantly improve bioavailability or reduce the off-target adverse effects. This chapter primarily focuses on recent advancements in phyto component loaded NCs employed for the treatment of brain disorders. The chapter especially covers existing impediments of phyto component based NCs for Parkinson and Alzheimer’s disease

    The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

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    The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

    Measurements of time-dependent CP violation in B meson decays to ψ(2S)k0s and φK0sγ

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    Ph.D. University of Hawaii at Manoa 2010.Includes bibliographical references.In this dissertation, we report improved measurements of time-dependent CP violation parameters for B0(B0) → ψ(2S)K0S. This analysis is based on a data sample of 657 × 106 BB pairs collected at the γ(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e− collider. One neutral B meson is fully reconstructed in the ψ(2S)K0S CP-eigenstate decay channel, and the flavor of the accompanying B meson is identified as either B0 or B0 from its decay products. CP violation parameters are obtained from the asymmetries in the distributions of the proper-time intervals between the two B decays: S (2S)K0S = +0.72 ± 0.09(stat) ± 0.03(syst), A (2S)K0S = +0.04 ± 0.07(stat) ±0.05(syst). We also report the first observation of the radiative decay B0 → φK0Sγ using a data sample of 772×106 BB pairs. We observe a signal of 37±8 events with a significance of 5.4 standard deviations including systematic uncertainties. The measured branching fraction is B(B0 → φK0γ) = (2.74 ± 0.60 ± 0.32) × 10−6, where the uncertainties are statistical and systematic, respectively. We also precisely measure B(B+ → φK+γ) = (2.48 ± 0.30 ± 0.24) × 10−6. The observed MφK mass spectrum differs significantly from that expected in a three-body phase-space decay. The radiative B → φKγ mode is sensitive to new physics from right-handed currents, which could affect the CP asymmetry. Here, we report the first measurement of timedependent CP violation parameters in the B0 → φK0Sγ mode : S = +0.74+0.72−1.05(stat)+0.10−0.24(syst), A = +0.35±0.58(stat)+0.23−0.10(syst). We also report a feasibility study for the radiative decay B → ωKγ

    Spectroscopic and Computational Study of Organocatalytic Umpolung of Bromocations: An Accelerated Stereoselective Dibromination Protocol

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    Herein, the reversal of polarity of cationic bromine, organocatalytically, is presented. NBS, a proven bromocation source was converted to a superior bromoanion reagent by H/Br exchange with a secondary amine, substantiated with spectroscopic and computational evidences. The concept has further been used in a successful accelerated organocatalyzed dibromination of olefins, in a non-hazardous, commercially viable process with a wide substrate scope. The reactivity of key entities has been observed through NMR kinetics and reaction acceleration using 10 mol% of catalyst loading accounts for its major success. The nucleophilicity of the bromoanion was found to be superior in comparison to other nucleophiles such as MeOH, H2O etc. and the protocol dominates over competing allylic bromination reaction