Estimation of Kumaraswamy Distribution Parameters Using the Principle of Maximum Entropy

This paper proposes using maximum entropy approach to estimate the parameters of the Kumaraswamy distribution subject to moment constraints. Kumaraswamy [7] introduced the double pounded probability density function which was originally used to model hydrological phenomena. It was mentioned that this probability density function is applicable to bounded natural phenomena which have values on two sides. The distribution share several properties with the beta distribution and it has the extra advantages that is possesses a closed form distribution function, but it remained unknown to most statisticians until it was developed by Jones [6] as a beta-type distribution with some tractability advantages in particular as it has fairly simple quantile function and it has explicit formula for L-Moment. Using the principle of maximum entropy to propose new estimators for the Kumaraswamy parameters and compared with maximum likelihood and Bayesian estimation methods. A simulation study is performed to investigate the performance of the estimators in terms of their mean square errors and their efficiency

ADSORPTION OF FOOD COLORING ALLURA RED DYE (E129) FROM AQUEOUS SOLUTIONS USING ACTIVATED CARBON

The adsorption behavior of Allura red (E129) from aqueous solutions onto activated carbon was successfully investigated. All factors affecting the adsorption process were carefully studied and the conditions were optimized. Adsorption of E129 onto activated carbon was found to increase by decreasing the mass of activated carbon, pH and ionic strength of the solution and by increasing temperature. The adsorption capacity of the activated carbon for Allura red was relatively high. Under the optimum conditions, the maximum adsorption capacity for E129 dye was 72.85 mg/g. Three adsorption models; Langmuir, Freundlich and Temkin model were investigated regarding the adsorption of E129. The models’ parameters KL, qm, R2, (n) were determined and found to be 0.0222, 72.85 mg/g, 0.9057-0.9984, and 0.992, respectively. Also, pseudo first and second-order kinetic models were tested to determine the best-fit model to the adsorption of E129 dye onto activated carbon. The results showed that the adsorption of E129 onto activated carbon obeyed both the Freundlich isotherm and pseudo second-order kinetic models. Moreover, thermodynamic studies indicated that the adsorption of E129 dye onto the activated carbon was spontaneous.Â

Novel Analytical Study For The Charge-Transfer Reactions Of Omeprazole With 2,3-Dichloro-Naphthoquinone And 2,3,5,6-Tetrabromo- 1,4-Benzoquinone: Application For The Development Of Microwell Assay Of Omeprazole

Novel analytical study was performed in order to develop and validate new high-throughput microwell-based spectrophotometric assays for determination of omeprazole (OMZ) in its pharmaceutical formulations. The proposed assays were based on the charge-transfer (CT) reaction of OMZ with 2,3-dichloronaphthoquinone (DCNQ) and 2,3,5,6-tetrabromo-1,4-benzo-quinone (BROM). In the present study, the CT reactions was carried out in microwell plates as reaction vessels in order to increase the automation of the assays and the efficiency of its use in quality control laboratories (QCLs). All factors affecting the CT reactions were carefully studied, and the conditions were optimized. Kinetics and stoichiometry of the CT reactions were investigated, and the mechanism was postulated. Activation energy of the CT reactions was determined and found to be 13.87 and 16.27 Kcal mol−1 for the reaction of OMZ with DCNQ and BROM, respectively. The initial rate and fixed time methods were applied for generating the calibration graphs for determination of OMZ concentrations. Under the optimum conditions, the linear range was 0.145 – 1.45 x 10-4 and 1.45 – 7.25 x 10-4 M with LOD of 0.6 and 6.0 microgram ml-1 for DCNQ and BROM, respectively. Analytical performance of the proposed methods, in terms of accuracy and precision, was statistically validated and the results were satisfactory; RSD was <2.8% for both repeatability and reproducibility. The proposed methods were successfully applied to the analysis of OMZ in its dosage forms and the recovery results (98.64 – 100.6 ± 0.25 -2.74 %) were comparable with those of the reported method. The developed method may provide a safer and economic tool for the analysis of OMZ in QCLs

أحكام الحضاةً في الفقه الإسلاهي هقارةً بقاوًى الأحوال الشخصية الليبي )دراسة فقهية مقارنة( Ahkam Al-hadhonah Fi Al-fiqh Al-Islamy Muqoranah Bi Qonun Al Wa As-Syakhshiyah Al-aliby

This message looking for a nursery in the provisions of Islamic jurisprudence and Libyan law. This thesis is applied for Islamic Law master Program, Muhammadiyyah University of Surakarta. Arranged by: Tahani Mahmoud Saad. NIM: O20012000. Supervised by Dr.Muhammad Muinudinillah Basry, MA and Dr. Mohamed Abdel Khalik Hassan. Year 2014 AD - 1435 H. This message qualitative research office, which made me posting this research, is the large number of issues on the nursery in the courtyard of the judiciary in the Libyan society and the problems of supply in the following research: how to reconcile the law with the Libyan Islamic jurisprudence in the door of the provisions of the nursery? Where my goal is to liberate accountable nursery comparative study of Islamic jurisprudence with Are said the four schools with Libyan law. The approach taken by the research methodology Allosteric analytical comparison. Find the most important findings: that the law of personal status Libyan nursery door is consistent with the Maliki school except for some cases, where interest requires otherwise, because throughout the nursery are the interests of the child and because the interest on the introduction of all other interests. As it became clear that the Libyan law leave it to the judge in some cases, in the interest of the child and for the judge to rule it under the authority and with what is agreed with the doctrine the militant also criticized the Libyan law did not address some of the texts in the nursery but there is a text item number (72, paragraph b) mentions where if there is no legislative text can be applied he is condemned under Islamic Sharia principles most relevant to the provisions of this law and this indicates that the Personal Status law in the Libyan nursery door with a conciliator Islamic jurisprudence because originally derives its legitimacy from Islamic jurisprudence

Optimizing the pterional approach in medial sphenoid wing meningioma:a detailed morphometric study on anterior clinoidectomy and its effect on operability score

Background Medial sphenoid wing meningiomas are best treated through pterional craniotomy, as pterional craniotomy provides wide and multidirectional exposure of the anterior and middle cranial fossa. Anterior clinoidectomy can increase the exposure potential. To delineate the role of anterior clinoidectomy (AC) in the standard pterional craniotomy approach through the evaluation of operability score measures (manoeuvrability arc, depth of surgical field, and surgical angle of attack). All patients with inner sphenoidal wing meningioma who underwent microsurgical excision between February 2022 and October 2023 were enrolled in the study. Preoperative and postoperative imaging studies (MR contrast studies and 3D thin-slice CT scans of the brain) were performed to determine the tumour size, extent, and pattern of optic canal involvement by comparing pre- and postoperative operability score parameters. Results Twenty-five patients met our inclusion criteria: 2 males (8%) and 23 females (92%). The mean age (SD) was 49.08 ± 6.42 years, with an age range of 39–60 years. The preoperative visual manifestations were as follows: eight patients (32%) had mild visual impairment, five patients (20%) had moderate visual impairment, six patients (24%) had severe visual impairment, and five patients (20%) had blindness. There was a significant positive correlation between the operability score and extent of resection (gross total resection was correlated with a higher operability score) (r = 0.301, n = 25, p = 0.005). Conclusions A well-planned manoeuvrable arc allows neurosurgeons to perform surgery with precision, ultimately impacting surgical outcomes and the potential for complete tumour removal with minimal patient morbidity.</p

The Response, Operability, and Type of Surgery Following Neoadjuvant Chemotherapy in Sudanese Patients with Locally Advanced Breast Cancer

Background:Neoadjuvant chemotherapy (NACT) treatment has become the standard treatment for locally advanced breast cancer (LABC) in many centers worldwide. Objectives: This study evaluates the short-term response of patients with LABC to NACT and its impact on operability and the type of surgery. Patients and Methods: This is a descriptive analytical hospital-based study including 147 patients with LABC who were presented to Plastic and Reconstructive Surgery Unit at Soba University hospital (SUH), between January 2012 and December 2014, and were treated with NACT. Clinical and pathological responses to neoadjuvant chemotherapy were evaluated according to Union for International Cancer Control criteria, operability, and the type of surgery performed was also recorded. Results: All patients were females, the mean age was 43 ± 7 years, of them 53.7% were pre-menopausal, 51% presented with a breast lump, 19.7% with nipple discharge, and 19% with skin changes and ulceration. The mean initial tumor size was 7 cm ± SD. Following NACT, complete clinical response was reported in 30 patients (20.4%), partial clinical response in 92(62.6%), stable clinical response in 20 (13.6%), and five (3.4%) had progressive clinical response. Initial smaller tumors (size &lt; 5 cm) showed a better clinical response to NACT as 76.7% of complete clinical response was achieved.Pathological complete response was achieved in 25(17%) patients, pathological partial response in 102(74.1%), and pathological stable disease in 13(8.8%). Following NACT, breast conserving surgery was performed in 78(53.1%) patients, Modified Radical Mastectomy in 64(43.5%), 25 of them had Latissimus Dorsi, and five patients were not offered surgery as they developed progressive disease during the study period. Conclusion: Following NACT, it was possible to perform surgery in more than 96% of patients with LABC

Alpaca against Vicuna: Using LLMs to Uncover Memorization of LLMs

In this paper, we introduce a black-box prompt optimization method that uses an attacker LLM agent to uncover higher levels of memorization in a victim agent, compared to what is revealed by prompting the target model with the training data directly, which is the dominant approach of quantifying memorization in LLMs. We use an iterative rejection-sampling optimization process to find instruction-based prompts with two main characteristics: (1) minimal overlap with the training data to avoid presenting the solution directly to the model, and (2) maximal overlap between the victim model's output and the training data, aiming to induce the victim to spit out training data. We observe that our instruction-based prompts generate outputs with 23.7% higher overlap with training data compared to the baseline prefix-suffix measurements. Our findings show that (1) instruction-tuned models can expose pre-training data as much as their base-models, if not more so, (2) contexts other than the original training data can lead to leakage, and (3) using instructions proposed by other LLMs can open a new avenue of automated attacks that we should further study and explore. The code can be found at https://github.com/Alymostafa/Instruction_based_attack