1999 Media Guide

1999 Men\u27s Track and Field Media Guide, George Fox College

Additional file 2: of Bibliometric trends of health economic evaluation in Sub-Saharan Africa

This is the R code for generating the visual network maps. (R 1 kb

Varieties of grapheme-colour synaesthesia: A new theory of phenomenological and behavioural differences

Recent research has suggested that not all grapheme-colour synaesthetes are alike. One suggestion is that they can be divided, phenomenologically, in terms of whether the colours are experienced in external or internal space (projector-associator distinction). Another suggestion is that they can be divided according to whether it is the perceptual or conceptual attributes of a stimulus that is critical (higher-lower distinction). This study compares the behavioural performance of 7 projector and 7 associator synaesthetes. We demonstrate that this distinction does not map on to behavioural traits expected from the higher-lower distinction. We replicate previous research showing that projectors are faster at naming their synaesthetic colours than veridical colours, and that associators show the reverse profile. Synaesthetes who project colours into external space but not on to the surface of the grapheme behave like associators on this task. In a second task, graphemes presented briefly in the periphery are more likely to elicit reports of colour in projectors than associators, but the colours only tend to be accurate when the grapheme itself is also accurately identified. We propose an alternative model of individual differences in grapheme-colour synaesthesia that emphasises the role of different spatial reference frames in synaesthetic perception. In doing so, we attempt to bring the synaesthesia literature closer to current models of non-synaesthetic perception, attention and binding

Additional file 3: of Bibliometric trends of health economic evaluation in Sub-Saharan Africa

Database of included studies and characteristics, network articles, authorship and collaborations. (XLSX 182 kb

Levelized Cost of Hydrogen from offtakers standpoint: An overlooked perspective via case studies in Warrnambool, Australia

Levelized Cost of Hydrogen from offtakers standpoint: An overlooked perspective via case studies in Warrnambool, Australi

Discovery tumor clinical characteristics.

<p>Discovery tumor clinical characteristics.</p

Expression Microarray Analysis Reveals Alternative Splicing of <i>LAMA3</i> and <i>DST</i> Genes in Head and Neck Squamous Cell Carcinoma

<div><p>Purpose</p><p>Prior studies have demonstrated tumor-specific alternative splicing events in various solid tumor types. The role of alternative splicing in the development and progression of head and neck squamous cell carcinoma (HNSCC) is unclear. Our study queried exon-level expression to implicate splice variants in HNSCC tumors.</p><p>Experimental Design</p><p>We performed a comparative genome-wide analysis of 44 HNSCC tumors and 25 uvulopalatopharyngoplasty (UPPP) tissue samples at an exon expression level. In our comparison we ranked genes based upon a novel score—the Maximum-Minimum Exon Score (MMES) – designed to predict the likelihood of an alternative splicing event occurring. We validated predicted alternative splicing events using quantitative RT-PCR on an independent cohort.</p><p>Results</p><p>After MMES scoring of 17,422 genes, the top 900 genes with the highest scores underwent additional manual inspection of expression patterns in a graphical analysis. The genes <i>LAMA3, DST, VEGFC, SDHA, RASIP1</i>, and <i>TP63</i> were selected for further validation studies because of a high frequency of alternative splicing suggested in our graphical analysis, and literature review showing their biological relevance and known splicing patterns. We confirmed <i>TP63</i> as having dominant expression of the short <i>DeltaNp63</i> isoform in HNSCC tumor samples, consistent with prior reports. Two of the six genes (<i>LAMA3</i> and <i>DST</i>) validated by quantitative RT-PCR for tumor-specific alternative splicing events (Student's t test, P<0.001).</p><p>Conclusion</p><p>Alternative splicing events of oncologically relevant proteins occur in HNSCC. The number of genes expressing tumor-specific splice variants needs further elucidation, as does the functional significance of selective isoform expression.</p></div

Validation tumor clinical characteristics.

<p>Validation tumor clinical characteristics.</p

Descriptive summary of genes selected for quantitative RT-PCR validation of alternative splicing events.

<p>Descriptive summary of genes selected for quantitative RT-PCR validation of alternative splicing events.</p

Demographic characteristics of validation tumor and UPPP normal tissue samples.

<p>Demographic characteristics of validation tumor and UPPP normal tissue samples.</p