Preparation and Characterization of (1-Me-indenyl)Ni(PR₃)(CC−Ph) (R = Cy, Ph) and Alkyne Polymerization Catalysis

The complexes (1-Me-Ind)(PR3)Ni−CC−Ph (R = Ph and Cy) have been prepared and characterized spectroscopically and by means of single-crystal structural analyses. These compounds are inert toward the insertion of alkynes, but when combined with methylaluminoxane (MAO), they form active catalysts for the homogeneous polymerization of phenylacetylene. cis-Poly(Ph−CC−H) is thus obtained with Mw values in the range of 104 and relatively narrow polydispersities. The combination of the corresponding Ni−Cl complexes with MAO gives similar results with Ph−CC−H and also polymerizes 1-hexyne and 3-hexyne, but the degree of polymerization is much lower. Optimization studies have shown that the polymerization reactions give the best results with THF as solvent and a 1:10 ratio of Ni to MAO. Evidence is presented for the involvement in the catalytic cycle of bimetallic species with a Ni(μ-X)(μ-Me)Al core

Nickel-Triflate Complexes as Precursors to Reactive Cations: Preparation and Reactivities of (1-R-indenyl)Ni(PPh₃)(OSO₂CF₃)

The complexes (1-R-indenyl)Ni(PPh3)(OTf) (OTf = OSO2CF3; R = Et (1), i-Pr (2), and Bz (3)) have been prepared by reacting the corresponding Ni-thienyl or Ni-Cl precursors with HOTf (triflic acid) or AgOTf, respectively. The triflate ligand in these complexes undergoes facile displacement by various substrates or ligands to facilitate (a) catalytic dimerization of ethylene, isomerization of 1-hexene, and polymerization of phenylacetylene, or (b) formation of the cationic complexes [(1-R-indenyl)(PPh3)Ni(L)]+ (R = i-Pr (a) and CH2Ph (b); L = CH3CN (4), PhCN (5), CO (6), Py (7), CNC(CH3)3 (8), PPh3 (9), and PMe3 (10)). Compounds 1−10 have been characterized spectroscopically and, in the case of complexes 2, 4a, and 8a, by single-crystal X-ray crystallography

Nickel-Triflate Complexes as Precursors to Reactive Cations: Preparation and Reactivities of (1-R-indenyl)Ni(PPh₃)(OSO₂CF₃)

The complexes (1-R-indenyl)Ni(PPh3)(OTf) (OTf = OSO2CF3; R = Et (1), i-Pr (2), and Bz (3)) have been prepared by reacting the corresponding Ni-thienyl or Ni-Cl precursors with HOTf (triflic acid) or AgOTf, respectively. The triflate ligand in these complexes undergoes facile displacement by various substrates or ligands to facilitate (a) catalytic dimerization of ethylene, isomerization of 1-hexene, and polymerization of phenylacetylene, or (b) formation of the cationic complexes [(1-R-indenyl)(PPh3)Ni(L)]+ (R = i-Pr (a) and CH2Ph (b); L = CH3CN (4), PhCN (5), CO (6), Py (7), CNC(CH3)3 (8), PPh3 (9), and PMe3 (10)). Compounds 1−10 have been characterized spectroscopically and, in the case of complexes 2, 4a, and 8a, by single-crystal X-ray crystallography

Data_Sheet_1_The Prevalence of Insufficient Sleep and Bedtime Delay Among Kindergarten Children Aged 3 to 6 Years in a Rural Area of Shanghai: A Cross-Sectional Study.PDF

Introduction: Sleep deprivation in children is a global public health problem that affects the physical and mental development of children. Bedtime delay induced by longer screen time and heavy study load is a common cause of sleep deprivation in children. However, the prevalence of insufficient sleep and bedtime delay and related influencing factors among kindergarten children is limited in Shanghai, China.Methods: In 2018, we selected 8,586 children aged 3 to 6 years and their parents in Songjiang District, Shanghai. Data was collected among parents by face-to-face questionnaire interview with signed informed consent. We defined insufficient sleep as those who slept for Results: The prevalence of insufficient sleep and bedtime delay among children aged 3 to 6 years was 11.67 and 56.85%, respectively. The prevalence of insufficient sleep among boys was slightly higher than among girls [odds ratio (OR) = 1.18, 95% confidence interval (CI): 1.04–1.35]. With the increase of the age of children, the prevalence of insufficient sleep increased gradually (P Conclusions: Insufficient sleep and bedtime delay were prevalent in Chinese children aged 3 to 6 years, especially in boys and older children. TV watching as well as parents accompanying for sleep were associated with insufficient sleep and bedtime delay. We recommend that parents should limit the screen time of children, advocate earlier bedtime and later morning wake-up among children, as well as make their children sleep in separate beds or rooms in younger age.</p

Psoriasis complicated with metabolic disorder is associated with traditional Chinese medicine syndrome types: a hospital-based retrospective case-control study

To explore the distribution law of traditional Chinese medicine (TCM) syndrome types in patients with psoriasis vulgaris complicated by metabolic disorders based on the same pathogenic factors as blood-heat and blood-stasis in the pathogenesis of psoriasis and metabolic disorders and to further analyze the correlation between adiponectin and the distribution law. From January 1, 2018, to December 31, 2019, patients diagnosed with psoriasis in the inpatient or outpatient department of Dermatology Ward of Shanghai Yueyang Hospital and normal participants who underwent physical examination in the physical examination center over the same period were retrospectively reviewed. Demographic data, medical history, metabolic disorder indices, and TCM syndrome indices of psoriasis patients and healthy volunteers were evaluated. We included 307 patients with psoriasis and 613 healthy controls. On analyzing past medical history, the proportion of overweight and obesity and the comorbidity of diabetes in the psoriasis group (53.42% and 14.66%) were significantly higher than in the control group (43.88% and 7.67%, respectively; P P P  TCM syndrome differentiation of psoriasis, especially the diagnosis of blood-stasis syndrome, prompts the early screening of patients with metabolic comorbidities. For patients with psoriasis with metabolic disorder, TCM for promoting blood circulation and removing blood stasis can be compatibly applied without contraindications. The trial was registered at ClinicalTrials.gov (Trial ID: NCT03942185).</p

Additional file 1: of Association between anthropometric indicators of obesity and cardiovascular risk factors among adults in Shanghai, China

Table S1. AUCs for anthropometric indices and CVD risk factors in men and women by age groups. Table S2. Optimal cut-off values for BMI, WC and WHtR that are predictive of CVD risk factors in men by age groups. Table S3. Optimal cut-off values for BMI, WC and WHtR that are predictive of CVD risk factors in women by age groups. (DOCX 30 kb

Functional Comparison between Genes Dysregulated in Ulcerative Colitis and Colorectal Carcinoma

<div><p>Background</p><p>Patients with ulcerative colitis (UC) are predisposed to colitis-associated colorectal cancer (CAC). However, the transcriptional mechanism of the transformation from UC to CAC is not fully understood.</p><p>Methodology</p><p>Firstly, we showed that CAC and non-UC-associated CRC were very similar in gene expression. Secondly, based on multiple datasets for UC and CRC, we extracted differentially expressed (DE) genes in UC and CRC versus normal controls, respectively. Thirdly, we compared the dysregulation directions (upregulation or downregulation) between DE genes of UC and CRC in CRC-related functions overrepresented with the DE genes of CRC, and proposed a regulatory model to explain the CRC-like dysregulation of genes in UC. A case study for “positive regulation of immune system process” was done to reveal the functional implication of DE genes with reversal dysregulations in these two diseases.</p><p>Principal Findings</p><p>In all the 44 detected CRC-related functions except for “viral transcription”, the dysregulation directions of DE genes in UC were significantly similar with their counterparts in CRC, and such CRC-like dysregulation in UC could be regulated by transcription factors affected by pro-inflammatory stimuli for colitis. A small portion of genes in each CRC-related function were dysregulated in opposite directions in the two diseases. The case study showed that genes related to humoral immunity specifically expressed in B cells tended to be upregulated in UC but downregulated in CRC.</p><p>Conclusions</p><p>The CRC-like dysregulation of genes in CRC-related functions in UC patients provides hints for understanding the transcriptional basis for UC to CRC transition. A small portion of genes with distinct dysregulation directions in each of the CRC-related functions in the two diseases implicate that their reversal dysregulations might be critical for UC to CRC transition. The cases study indicates that the humoral immune response might be inhibited during the transformation from UC to CRC.</p></div

Additional file 2: of Association between anthropometric indicators of obesity and cardiovascular risk factors among adults in Shanghai, China

Questionnaire. (DOCX 57 kb

Data_Sheet_2_Epidemiological Characteristics of Infectious Diseases Among Travelers Between China and Foreign Countries Before and During the Early Stage of the COVID-19 Pandemic.ZIP

Background: International travel during the Coronavirus disease 2019 (COVID-19) pandemic carries a certain magnitude of infection risk both to travelers and their destination, which may be difficult to assess in the early stage. The characteristics of common infectious diseases of tourists may provide some clues to identify the high-risk travelers and protect susceptible population.Methods: From among 48,444 travelers screened at Shanghai Port, we analyzed 577 travelers with 590 infectious diseases for age, sex, disease type, and World Health Organization (WHO) regions. We used the Joinpoint Regression Program to identify the average percent changes (APC) in the various trends among these individuals.Results: Hepatitis B, syphilis, and HIV were the most common infectious diseases in travelers entering China, and Hepatitis B, pulmonary tuberculosis, and syphilis in Chinese nationals traveling abroad (overall detection rates, 1.43 and 0.74%, respectively; P 0.05) and rather showed an upward trend with increasing age [APC 95% CI = 5.46 (3.41,7.56)%, P 0.05).Conclusion: Travelers always carry a transmission risk of common infectious diseases. It may be reasonable to adjust strategies for airport screening and quarantine according to the age and departure area of travelers to prevent and control new infectious diseases.</p

The consistency of every two datasets for CRC.

<p><b>Notes:</b> *(number1/number2) followed the percentage of the DE genes with consistent dysregulation direction in all commonly detected DE genes between two datasets represent the number of the DE genes with consistent dysregulation direction and the number of all commonly detected DE genes, respectively.</p