Two new eremophilane Sesquiterpenoides from <i>Ligularia dictyoneura</i>

Two new eremophilane sesquiterpenoides, 6α,9α-dihydroxyeremophilenolide (1), and 1β,10β-dihydroxyeremophilenolide (2), along with ten known eremophilane sesquiterpenoides (3–12) were isolated from the aerial parts of Ligularia dictyoneura (Franch.) Hand.-Mazz. Their structures were elucidated by means of extensive spectroscopic analysis. Compounds 3–6 were assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that they had no activity.</p

A new (propylphenyl)bibenzyl from <i>Eria bambusifolia</i>

<p>A new (propylphenyl)bibenzyl, bambusifolol (<b>1</b>), along with six known compounds, batatasin III (<b>2</b>), tristin (<b>3</b>), 3-hydroxy-5-methoxy bibenzyl (<b>4</b>), gigantol (<b>5</b>), 3′,5-dimethoxy-9,9′-diacetyl-4,7′-epoxy-3,8′-bilign-7-ene-4′-methol (<b>6</b>) and balanophonin (<b>7</b>) were isolated from the whole plants of <i>Eria bambusifolia</i>. Their structures were elucidated by the means of extensive spectroscopic analysis. <b>3</b>–<b>7</b> were isolated from the genus <i>Eria</i> for the first time and <b>2</b> obtained originally from <i>E. bambusifolia</i>. All the compounds isolated were evaluated for their cytotoxicity against human tumour HL-60, SMMC-7721, A-549, MCF-7 and SW-480 cell lines, but none showed significant activity.</p

A new isoflavanone from the trunk of <i>Horsfieldia pandurifolia</i>

<div><p>A new isoflavanone, 2,2′-epoxy-4′-methoxy-3,7-dihydroxyisoflavanone (<b>1</b>), and a new natural coumaranone, 2-hyroxy-2-(4′-methoxybenzyl)-6-methoxy-3-coumaranone (<b>2</b>), along with 26 known compounds, were first isolated from the trunk of <i>Horsfieldia pandurifolia</i>. Their structures were elucidated by the means of spectroscopic analysis. Compound <b>1</b> was assessed for its cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that it has no activity.</p></div

Aromatic compounds from <i>Endocomia macrocoma</i>

Twenty-seven compounds, including a new diarypropane and two new lignans were isolated from the twigs and leaves of Endocomia macrocoma. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation of the new compounds against five human tumor lines showed no inhibitory effects. </p

Two new flavans from the trunk and leaves of <i>Horsfieldia glabra</i>

<p>Two new flavans, (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′,5′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>1</b>), and (2<i>R</i>, 4<i>R</i>)-4′-hydroxy-3′-methyl-6,7-methylenedioxy-4-<i>O</i>-2′-cycloflavan (<b>2</b>), along with six known compounds were isolated from the trunk and leaves of <i>Horsfieldia glabra</i>. Their structures were elucidated by means of extensive spectroscopic analysis. Compounds <b>1</b> and <b>2</b>, together with <b>4</b>–<b>7</b> were assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and the result showed that they had no activity.</p

Diarylpropanes from <i>Horsfieldia kingii</i>

Three new diarylpropanes (1–3), including two diarylpropane glycosides, and three known ones, were isolated from 70% aqueous acetone extract of the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Bioactive evaluation of inhibition on DDC enzyme assay showed that the new compounds were inactive.</p

A new neolignan from the thorns of <i>Gleditsia japonica var. delavayi</i>

A new neolignan, 5-(3″-acetoxypropyl)-2-(4′-hydroxy-3′-methoxyphenyl)-7-methoxy-3-methylbenzofuran (1) along with nine analogues were isolated from the thorns of Gleditsia japonica var. delavayi by solvent extraction and repeated column chromatography. Their structures were elucidated by means of extensive spectroscopic analysis including 1D, 2D-NMR techniques and HR-ESIMS. All the isolates were reported for the first time from this species.</p

Two new flavonol glycosides from <i>Dimocarpus longan</i> leaves

<div><p>From the extracts of <i>Dimocarpus longan</i> Lour leaves, 2 unusual flavonol glycosides, quercetin 3-<i>O</i>-(3″-<i>O</i>-2‴-methyl-2‴-hydroxylethyl)-β-d-xyloside (<b>1</b>) and quercetin 3-<i>O</i>-(3″-<i>O</i>-2‴-methyl-2‴-hydroxylethyl)-α-l-rhamnopyranoside (<b>2</b>), as well as 10 known compounds including 2 flavonol glycosides, afzelin (<b>3</b>) and kaempferol-3-<i>O</i>-α-l-rhamnopyranoside (<b>4</b>), 2 flavans, ( − )-epicatechin (<b>5</b>) and proanthocyanidin A-2 (<b>6</b>), 3 triterpenoids, friedelin (<b>7</b>), epifriedelanol (<b>8</b>) and β-amyrin (<b>9</b>), a peptide, <i>N</i>-benzoylphenylalanyl-<i>N</i>-benzoylphenylalaninate (<b>10</b>), and 2 sterols, β-sitosterol (<b>11</b>) and daucosterol (<b>12</b>) were isolated and identified by using combination of mass spectrometry and various 1D and 2D NMR techniques. This is the first report of flavonoid glycosides possessing a 2-methyl-2-hydroxylethoxyl group in sugar moiety from <i>D. longan</i>.</p></div

A New Lycopodine-type Alkaloid from <i>Lycopodium japonicum</i>

<p>A new lycopodine-type alkaloid, 12<i>β</i>-hydroxy-acetylfawcettiine <i>N</i>-oxide (<b>1</b>), together with seven known analogues, acetyllycoposerramine M (<b>2</b>), lycopodine (<b>3</b>), lycoclavine (<b>4</b>), diphaladine A (<b>5</b>), lycoposerramine K (<b>6</b>), 11<i>β</i>-hydroxy-12-<i>epi</i>lycodoline (<b>7</b>) and fawcettiine (<b>8</b>), were isolated from <i>Lycopodium japonicum</i>. Their structures were established by mass spectrometry and 1D and 2D NMR techniques. The isolated alkaloids were assayed for their inhibition activities against acetylcholinesterase, but no inhibitory activities for the compounds were detected.</p

Isolation of a new lycodine alkaloid from <i>Lycopodium japonicum</i>

<div><p>A new lycodine alkaloid, <i>N</i>-methylhydroxypropyllycodine (<b>1</b>), was isolated from the club moss <i>Lycopodium japonicum</i> Thunb, together with five known compounds, <i>N</i>-methyllycodine (<b>2</b>), huperzinine (<b>3</b>), β-obscurine (<b>4</b>), α-obscurine (<b>5</b>) and des-<i>N</i>-methyl-α-obscurine (<b>6</b>). Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques.</p></div