sj-docx-1-pss-10.1177_09567976211052476 – Supplemental material for Sustained Stress Reduces the Age Advantages in Emotional Experience of Older Adults: Commentary on Carstensen et al. (2020)

Supplemental material, sj-docx-1-pss-10.1177_09567976211052476 for Sustained Stress Reduces the Age Advantages in Emotional Experience of Older Adults: Commentary on Carstensen et al. (2020) by Rui Sun and Disa Sauter in Psychological Science</p

The results of polynomial regression.

The results of polynomial regression.</p

Means, standard deviation and correlation.

Means, standard deviation and correlation.</p

sj-docx-1-spp-10.1177_19485506231218362 – Supplemental material for Why Being Social and Active Boosts Psychological Wellbeing: A Mediating Role of Momentary Positive Emotions

Supplemental material, sj-docx-1-spp-10.1177_19485506231218362 for Why Being Social and Active Boosts Psychological Wellbeing: A Mediating Role of Momentary Positive Emotions by Rui Sun, Irene Teulings and Disa Sauter in Social Psychological and Personality Science</p

Bootstrapping of three-way interaction effects.

Bootstrapping of three-way interaction effects.</p

Cellular mechanisms and clinical applications for phenocopies of inborn errors of immunity: infectious susceptibility due to cytokine autoantibodies

With a growing knowledge of Inborn errors immunity (IEI), immunological profiling and genetic predisposition to IEI phenocopies have been developed in recent years. Here we summarized the correlation between various pathogen invasions, autoantibody profiles, and corresponding clinical features in the context of patients with IEI phenocopies. It has been extensively evident that patients with anti-cytokine autoantibodies underly impaired anti-pathogen immune responses and lead to broad unregulated inflammation and tissue damage. Several hypotheses of anti-cytokine autoantibodies production are summarized here, including a defective negative selection of autoreactive T cells, abnormal germinal center formation, molecular mimicry, HLA class II allele region, lack of auto-reactive lymphocyte apoptosis, and other possible hypotheses. Phenocopies of IEI associated with anti-cytokine autoantibodies are increasingly recognized as one of the causes of acquired immunodeficiency and susceptibility to certain pathogen infections, especially facing the current challenge of the COVID-19 pandemic. By investigating clinical, genetic, and pathogenesis autoantibodies profiles associated with various pathogens’ susceptibilities, we could better understand the IEI phenocopies with anti-cytokine autoantibodies, especially for those that underlie life-threatening SARS-CoV-2.</p

A congruence perspective on how human and social capital affect learning capability and innovation

Human capital and social capital are vital for sustainable development of organization, but existing studies are inadequate to explore the synergistic effect of them on organizational behaviors or organizational outcomes. The research employed multiple-source questionnaire to collect data of more than 400 R&D firms from leaders and corresponding employees in Chinese context. Bootstrapping method and response surface were used to analyze the associations between all the parameters. The results showed that: (1) in the case of the in-congruence between human capital and social capital, learning capability of R&D firms is at highest level when human capital is at low level and social capital is at high level; (2) learning capability partially mediates the impact of human capital and social capital on innovation performance; (3) environmental dynamism and environmental competitiveness have a joint moderating effect on the relationship between learning capability and innovation performance.</div

Atomistic Insight into the Lipid Nanodomains of Synaptic Vesicles

Membrane curvature, once regarded as a passive consequence of membrane composition and cellular architecture, has been shown to actively modulate various properties of the cellular membrane. These changes could also lead to segregation of the constituents of the membrane, generating nanodomains with precise biological properties. Proteins often linked with neurodegeneration (e.g., tau, alpha-synuclein) exhibit an unintuitive affinity for synaptic vesicles in neurons, which are reported to lack distinct, ordered nanodomains based on their composition. In this study, all-atom molecular dynamics simulations are used to study a full-scale synaptic vesicle of realistic Gaussian curvature and its effect on the membrane dynamics and lipid nanodomain organization. Compelling indicators of nanodomain formation, from the perspective of composition, surface areas per lipid, order parameter, and domain lifetime, are identified in the vesicle membrane, which are absent in a flat bilayer of the same lipid composition. Therefore, our study supports the idea that curvature may induce phase separation in an otherwise fluid, disordered membrane

Bootstrapping of mediation effects.

Bootstrapping of mediation effects.</p

Capital matching situation.

Capital matching situation.</p