Structures and fluorescent properties of picolinato zinc(II) and cadmium(II) complexes based on tridentate and tetradentate benzimidazole ligands

<p>Five picolinato zinc(II) and cadmium(II) complexes, [Zn(ntb)(pic)]ClO₄·CH₃OH·2H₂O (<b>1</b>), [Zn(bbma)(pic)]NO₃·2CH₃OH (<b>2</b>), [Cd(ntb)(pic)]ClO₄·0.75CH₃OH·H₂O (<b>3</b>), [Cd₂(bbma)₂(pic)₂](ClO₄)₂ (<b>4</b>), and [Cd₂(bbp)(bbp_-H)(pic)₂(C₂H₅OH)]ClO₄ (<b>5</b>), have been synthesized, where pic is the anion of picolinic acid, ntb is tris(2-benzimidazolylmethyl)amine, bbma is bis(benzimidazol-2-yl-methyl)amine, and bbp is 2,6-bis(benzimidazol-2-yl)pyridine. All the complexes were characterized by X-ray single-crystal diffraction, elemental analysis, IR, fluorescence spectroscopy, and thermal gravimetric analysis. <b>1</b>–<b>3</b> are mononuclear complexes in which picolinate adopts a N,O-chelating mode. <b>4</b> is a symmetrical dinuclear complex bridged by two anti-parallel picolinates in a N,O,O-coordination mode. <b>5</b> is also a dinuclear complex in which only one picolinate is a bridge. A 1-D double chain is formed by extensive H-bonds and <i>π</i>–<i>π</i> stacking in <b>1</b>, while single zigzag chains are formed in <b>5</b>. Complexes <b>2</b>–<b>4</b> all exhibit 6³-hcb 2-D frameworks. They extend to form four-connected 6⁶-dia 3-D topological nets for <b>2</b> and <b>4</b> and five-connected 4⁶·6⁴-bnn 3-D topological nets for <b>3</b>. The five complexes show emission maxima in the blue region in the solid state.</p

Table2_Cost-effectiveness of rezvilutamide versus bicalutamide and androgen-deprivation therapy in patients with highvolume, metastatic, hormone-sensitive prostate cancer.XLSX

Background: Rezvilutamide, a novel androgen-receptor inhibitor with limited blood-brain barrier penetration, exhibits significant antitumour activity against highvolume, metastatic, hormone-sensitive prostate cancer (mHSPC). In this study, we aimed to compare the cost-effectiveness of rezvilutamide and bicalutamide as first-line treatments for untreated prostate cancer among Chinese patients, in order to evaluate the efficacy of rezvilutamide.Methods: In this study, we utilized partition survival model to assess the cost-effectiveness of rezvilutamide and bicalutamide treatments for highvolume mHSPC. The model was developed using TreeAge Pro 2022 software and relied on clinical data obtained from the CHART trial. Transition probabilities were estimated from the reported survival probabilities in trials using parametric survival modeling. From the perspective of the Chinese healthcare system, we calculated quality-adjusted life years (QALYs), incremental cost-effectiveness ratio (ICER), and lifetime cost. A lifetime horizon and an annual discount rate of 5% were employed. To address modeling uncertainties, we conducted one-way sensitivity analysis and probabilistic sensitivity analysis.Results: The cost of rezvilutamide versus bicalutamide were $62700 and$13200. Rezvilutamide had an ICER of $41900 per additional QALYs gained compared with bicalutamide. Research indicated that rezvilutamide achieved at least an 28.20$38223.34/QALY. One-way sensitivity analysis revealed that the results were sensitive to utility of PD. Scenario analysis showed that rezvilutamide was cost-effectiveness if its price was reduced by more than 10%.Conclusion: Based on the analysis at the current price, rezvilutamide was found to be less cost-effective for patients with highvolume mHSPC compared to bicalutamide in China.</p

Table1_Cost-effectiveness of rezvilutamide versus bicalutamide and androgen-deprivation therapy in patients with highvolume, metastatic, hormone-sensitive prostate cancer.XLSX

Background: Rezvilutamide, a novel androgen-receptor inhibitor with limited blood-brain barrier penetration, exhibits significant antitumour activity against highvolume, metastatic, hormone-sensitive prostate cancer (mHSPC). In this study, we aimed to compare the cost-effectiveness of rezvilutamide and bicalutamide as first-line treatments for untreated prostate cancer among Chinese patients, in order to evaluate the efficacy of rezvilutamide.Methods: In this study, we utilized partition survival model to assess the cost-effectiveness of rezvilutamide and bicalutamide treatments for highvolume mHSPC. The model was developed using TreeAge Pro 2022 software and relied on clinical data obtained from the CHART trial. Transition probabilities were estimated from the reported survival probabilities in trials using parametric survival modeling. From the perspective of the Chinese healthcare system, we calculated quality-adjusted life years (QALYs), incremental cost-effectiveness ratio (ICER), and lifetime cost. A lifetime horizon and an annual discount rate of 5% were employed. To address modeling uncertainties, we conducted one-way sensitivity analysis and probabilistic sensitivity analysis.Results: The cost of rezvilutamide versus bicalutamide were $62700 and$13200. Rezvilutamide had an ICER of $41900 per additional QALYs gained compared with bicalutamide. Research indicated that rezvilutamide achieved at least an 28.20$38223.34/QALY. One-way sensitivity analysis revealed that the results were sensitive to utility of PD. Scenario analysis showed that rezvilutamide was cost-effectiveness if its price was reduced by more than 10%.Conclusion: Based on the analysis at the current price, rezvilutamide was found to be less cost-effective for patients with highvolume mHSPC compared to bicalutamide in China.</p

Hydrophilic Magnetofluorescent Nanobowls: Rapid Magnetic Response and Efficient Photoluminescence

Multifunctional integration based on a single nanostructure is emerging as a promising paradigm to future functional materials. In this paper, novel magnetofluorescence nanobowls built with ferroferric mandrel and quantum dots exoderm is reported. Magnetic mandrels are stacked into nanobowls though hydrophobic primary Fe₃O₄ nanocrystals dragged into anion polyelectrolyte aqueous solution via forced solvent evaporation. Bright luminescence core/shell/shell CdSe/CdS/ZnS quantum dots (QDs) are modified with cationic hyperbranched polyethylenimine (PEI). Through electrostatic interactions, positively charged PEI-coated QDs are anchored on the surface of magnetic mandrel. Under this method, the luminescence of QDs is not quenched by magnetic partners in the resultant magnetoflurescence nanobowls. Such magnetoflurescence nanobowls exhibit high saturation magnetization, superparamagnetic characteristics at room temperature, superior water dispersibility, and excellent photoluminescence properties. The newly developed magnetoflurescence nanobowls open a new dimension in efforts toward multimodal imaging probes combining strong magnetization and efficient fluorescence in tandem for biosensors and clinical diagnostic imaging

Inclusion/exclusion criteria.

<p> IMN: intramedullary nail; DCP: dynamic compression plate.</p

Forest plot for the risk ratio (RR) estimate for the rate of intraoperative fracture comminution.

<p>RR = 3.14 (95% CI, 1.02–9.64).</p

Characteristics of the included studies.

<p> IMN: intramedullary nailing; DCP: dynamic compression plate; RCT: randomized control trial; NA: not available; mo: months.</p

Presentation_1.PDF

<p>Qianlie Xiaozheng decoction (QLXZD), a traditional Chinese medicinal formula, has been used clinically to treat advanced prostate cancer (PCa) for more than 10 years. However, experimental evidence supporting its efficacy is lacking. Here, we investigated the anticancer properties and molecular mechanism of QLXZD in vitro in a human PCa cell line (PC3) and in vivo using PC3 xenografts in nude mice. We confirmed the antineoplastic activity of QLXZD by analyzing cell viability and tumor volume growth, which decreased significantly compared to that of the controls. Autophagy following QLXZD treatment was detected morphologically using transmission electron microscopy and was confirmed by measuring the expression of autophagy markers (LC3-II and p62) using fluorescence analysis, flow cytometry, and western blotting. Increasing autophagic flux induced by QLXZD was monitored via pmCherry-GFP-LC3 fluorescence analysis. QLXZD-induced autophagic cell death was alleviated by the autophagy inhibitors, 3-methyl adenine and hydroxychloroquine. We evaluated the total expression and phosphorylation levels of proteins involved in the Akt/mTOR pathway regulating autophagy. Phosphorylation of Akt, mTOR, and p70S6K, but not total protein levels, decreased following treatment. This is the first study to demonstrate the autophagy-related mechanistic pathways utilized during QLXZD-mediated antitumor activity both in vitro and in vivo. These findings support the clinical use of QLXZD for PCa treatment.</p

Intramedullary Nail versus Dynamic Compression Plate Fixation in Treating Humeral Shaft Fractures: Grading the Evidence through a Meta-Analysis

<div><p>There is a debate regarding the choice of operative intervention in humeral shaft fractures that require surgical intervention. The choices for operative interventions include intramedullary nailing (IMN) and dynamic compression plate (DCP). This meta-analysis was performed to compare fracture union, functional outcomes, and complication rates in patients treated with IMN or DCP for humeral shaft fractures and to develop GRADE (Grading of Recommendations, Assessment, Development, and Evaluation)-based recommendations for using the procedures to treat humeral shaft fractures. A systematic search of all the studies published through December 2012 was conducted using the Medline, Embase, Sciencedirect, OVID and Cochrane Central databases. The randomized controlled trials (RCTs) and quasi-RCTs that compared IMN with DCP in treating adult patients with humeral shaft fractures and provided data regarding the safety and clinical effects were identified. The demographic characteristics, adverse events and clinical outcomes were manually extracted from all of the selected studies. Ten studies that included a total of 448 patients met the inclusion criteria. The results of a meta-analysis indicated that both IMN and DCP can achieve similar fracture union with a similar incidence of radial nerve injury and infection. IMN was associated with an increased risk of shoulder impingement, more restriction of shoulder movement, an increased risk of intraoperative fracture comminution, a higher incidence of implant failure, and an increased risk of re-operation. The overall GRADE system evidence quality was very low, which reduces our confidence in the recommendations of this system. DCP may be superior to IMN in the treatment of humeral shaft fractures. Because of the low quality evidence currently available, high-quality RCTs are required.</p></div

Broadband and Lightweight Microwave Absorber Constructed by in Situ Growth of Hierarchical CoFe₂O₄/Reduced Graphene Oxide Porous Nanocomposites

A broadband and lightweight microwave absorber has attracted soaring research interest because of the increasing demand for electronic reliability and defense security. Lightweight ferrites/graphene porous composites with abundant interfaces are potential high-performance absorbers owing to their balanced attenuation ability and impedance matching. Herein, we synthesized hierarchical CoFe₂O₄/reduced graphene oxide (CFO/rGO) nanocomposites with a porous structure via an in situ solvothermal method. The electromagnetic parameters of CFO/rGO nanocomposites can be well-adjusted by modulating the weight fraction of rGO. The hierarchical porous structure and proper electromagnetic parameters result in the enhancement of impedance matching and attenuation ability. Benefiting from the controllable composition, hierarchical porous structure, and strong synergetic effect between CFO and rGO sheets, as expected, CFO/rGO nanocomposites exhibit superior microwave absorption performance with an ultrabroad bandwidth reaching 5.8 GHz (8.3–14.1 GHz) with a thin thickness of 2.8 mm. Meanwhile, a strong reflection loss of −57.7 dB at the same thickness is achieved. Considering the outstanding microwave absorption performance, the hierarchical CFO/rGO porous nanocomposites can be employed as a high-performance microwave absorber