41 research outputs found

    Senior Recital: Christian Rucinski, Clarinet; Momoko Gresham, Piano; April 7, 2024

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    Kemp Recital HallApril 7, 2024Sunday Afternoon4:00 p.m

    Tension of knotted surgical sutures shows tissue specific rapid loss in a rodent model

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    <p>Abstract</p> <p>Background</p> <p>Every surgical suture compresses the enclosed tissue with a tension that depends from the knotting force and the resistance of the tissue. The aim of this study was to identify the dynamic change of applied suture tension with regard to the tissue specific cutting reaction.</p> <p>Methods</p> <p>In rabbits we placed single polypropylene sutures (3/0) in skin, muscle, liver, stomach and small intestine. Six measurements for each single organ were determined by tension sensors for 60 minutes. We collected tissue specimens to analyse the connective tissue stability by measuring the collagen/protein content.</p> <p>Results</p> <p>We identified three phases in the process of suture loosening. The initial rapid loss of the first phase lasts only one minute. It can be regarded as cutting through damage of the tissue. The percentage of lost tension is closely related to the collagen content of the tissue (r = -0.424; p = 0.016). The second phase is characterized by a slower decrease of suture tension, reflecting a tissue specific plastic deformation. Phase 3 is characterized by a plateau representing the remaining structural stability of the tissue. The ratio of remaining tension to initial tension of phase 1 is closely related to the collagen content of the tissue (r = 0.392; p = 0.026).</p> <p>Conclusions</p> <p>Knotted non-elastic monofilament sutures rapidly loose tension. The initial phase of high tension may be narrowed by reduction of the surgeons' initial force of the sutures' elasticity to those of the tissue. Further studies have to confirm, whether reduced tissue compression and less local damage permits improved wound healing.</p

    The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

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    The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

    First detection of gas-phase ammonia in a planet-forming disk. NH₃, N₂Hâș, and H₂O in the disk around TW Hydrae

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    Context. Nitrogen chemistry in protoplanetary disks and the freeze-out on dust particles is key for understanding the formation of nitrogen-bearing species in early solar system analogs. In dense cores, 10% to 20% of the nitrogen reservoir is locked up in ices such as NH3, NH4+ and OCN−. So far, ammonia has not been detected beyond the snowline in protoplanetary disks. Aims. We aim to find gas-phase ammonia in a protoplanetary disk and characterize its abundance with respect to water vapor. Methods. Using HIFI on the Herschel Space Observatory, we detected for the first time the ground-state rotational emission of ortho-NH3 in a protoplanetary disk around TW Hya. We used detailed models of the disk’s physical structure and the chemistry of ammonia and water to infer the amounts of gas-phase molecules of these species. We explored two radial distributions (extended across the disk and confined to <60 au like the millimeter-sized grains) and two vertical distributions (near the midplane and at intermediate heights above the midplane, where water is expected to photodesorb off icy grains) to describe the (unknown) location of the molecules. These distributions capture the effects of radial drift and vertical settling of ice-covered grains. Results. The NH310–00 line is detected simultaneously with H2O 110–101 at an antenna temperature of 15.3 mK in the Herschel beam; the same spectrum also contains the N2H+ 6–5 line with a strength of 18.1 mK. We use physical-chemical models to reproduce the fluxes and assume that water and ammonia are cospatial. We infer ammonia gas-phase masses of 0.7−11.0 × 1021 g, depending on the adopted spatial distribution, in line with previous literature estimates. For water, we infer gas-phase masses of 0.2−16.0 × 1022 g, improving upon earlier literature estimates This corresponds to NH3/H2O abundance ratios of 7%−84%, assuming that water and ammonia are co-located. The inferred N2H+ gas mass of 4.9 × 1021 g agrees well with earlier literature estimates that were based on lower excitation transitions. These masses correspond to a disk-averaged abundances of 0.2−17.0 × 10-11, 0.1−9.0 × 10-10 and 7.6 × 10-11 for NH3, H2O and N2H+ respectively. Conclusions. Only in the most compact and settled adopted configuration is the inferred NH3/H2O consistent with interstellar ices and solar system bodies of ~5%–10%; all other spatial distributions require additional gas-phase NH3 production mechanisms. Volatile release in the midplane may occur through collisions between icy bodies if the available surface for subsequent freeze-out is significantly reduced, for instance, through growth of small grains into pebbles or larger bodies

    Search for transiting exoplanets and variable stars in the open cluster NGC 7243

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    We report results of the first five observing campaigns for the open stellar cluster NGC 7243 in the frame of project Young Exoplanet Transit Initiative (YETI). The project focuses on the monitoring of young and nearby stellar clusters, with the aim to detect young transiting exoplanets and to study other variability phenomena on time‐scales from minutes to years. After five observing campaigns and additional observations during 2013 and 2014, a clear and repeating transit‐like signal was detected in the light curve of J221550.6+495611. Furthermore, we detected and analysed 37 new eclipsing binary stars in the studied region. The best fit parameters and light curves of all systems are given. Finally, we detected and analysed 26 new, presumably pulsating variable stars in the studied region. The follow‐up investigation of these objects, including spectroscopic measurements of the exoplanet candidate, is currently planned

    AI is a viable alternative to high throughput screening: a 318-target study

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    : High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNetÂź convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNetÂź model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

    The DUNE Far Detector Interim Design Report, Volume 3: Dual-Phase Module

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    The DUNE IDR describes the proposed physics program and technical designs of the DUNE far detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 3 describes the dual-phase module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure

    The DUNE Far Detector Interim Design Report, Volume 3: Dual-Phase Module

    Get PDF
    The DUNE IDR describes the proposed physics program and technical designs of the DUNE far detector modules in preparation for the full TDR to be published in 2019. It is intended as an intermediate milestone on the path to a full TDR, justifying the technical choices that flow down from the high-level physics goals through requirements at all levels of the Project. These design choices will enable the DUNE experiment to make the ground-breaking discoveries that will help to answer fundamental physics questions. Volume 3 describes the dual-phase module's subsystems, the technical coordination required for its design, construction, installation, and integration, and its organizational structure
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