1,313 research outputs found

    PUNTA AL LLAPIS. Ús de macròlids en el tractament de la fibrosi quística

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    Assessment of Cancer-related Cognitive Impairment: Methodological Issues

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    Cognitive decline associated with cancer or its treatment has been addressed in many studies, though with inconsistent findings, which largely reflects the diversity of methods that have been used. In this context, we read with much interest the paper recently published in the Archives of Clinical Neuropsychology (Clapp et al., 2018) about the impact of using different reference populations on breast cancer-related cognitive impairment rates, which was based on a thorough assessment of a large number of cancer patients and non-cancer subjects

    One-year regional brain volume changes as potential predictors of cognitive function in multiple sclerosis: a pilot study

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    BackgroundThe most reliable magnetic resonance imaging (MRI) marker of cognitive dysfunction in multiple sclerosis (MS) is brain atrophy. However, 1-year volumetric changes prior to cognitive assessment were never studied as potential predictors of cognition, which we aim to assess with this pilot work.MethodsTwenty-two MS patients were submitted to a baseline measure of 83 regional brain volumes with MRI and re-evaluated 1 year later; they were also tested with the Brief International Cognitive Assessment for MS (BICAMS): sustained attention and processing speed were examined with the Symbol Digit Modalities Test (SDMT), verbal and visuo-spatial learning and memory with the learning trials from the California Verbal Learning Test-II (CVLT) and the Brief Visuo-spatial Memory Test-revised (BVMT), respectively. Controlling for age, sex, and years of education, a multivariate linear regression model was created for each cognitive score at 1-year follow-up in a backward elimination manner, considering cross-sectional regional volumes and 1-year volume changes as potential predictors.ResultsDecreases in the volumes of the left amygdala and the right lateral orbitofrontal cortex in the year prior to assessment were identified as possible predictors of worse performance in verbal memory (P = 0.009) and visuo-spatial memory (P = 0.001), respectively, independently of cross-sectional brain regional volumes at time of testing.ConclusionOur work reveals novel 1-year regional brain volume changes as potential predictors of cognitive deficits in MS. This suggests a possible role of these regions in such deficits and might contribute to uncover cognitively deteriorating patients, whose detection is still unsatisfying in clinical practice.Open access funding provided by FCT|FCCN (b-on). Biogen, Fundacao para a Ciencia e Tecnologia, UIDB/50026/2020, Fundacao para a ciencia e tecnologia, UIDP/50026/2020, Fundacao para a Ciencia e a Tecnologia, EXPL/MEC-NEU/0888/2021, Torcato Meira

    “Anti-Michael addition” of Grignard reagents to sulfonylacetylenes: synthesis of alkynes

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    In this work, the addition of Grignard reagents to arylsulfonylacetylenes, which undergoes an “anti-Michael addition”, resulting in their alkynylation under very mild conditions is described. The simplicity of the experimental procedure and the functional group tolerance are the main features of this methodology. This is an important advantage over the use of organolithium at −78 °C that we previously reported. Moreover, the synthesis of diynes and other examples showing functional group tolerance in this anti-Michael reaction is also presentedFinancial support from the Spanish Government CTQ2012- 35957 (MINECO) and CTQ2015-64561-R (MINECO/FEDER) is gratefully acknowledged. F. E. is thankful to the Spanish government for a FPI fellowship, and L. B. is thankful to the Université Badji Mokhtar Annaba for a predoctoral stay gran

    La personalidad jurídica civil de las fundaciones canónicas en España

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    La personalidad jurídica constituye un instrumento necesario para que una determinada entidad, de naturaleza asociativa o patrimonial, pueda actuar en el tráfico jurídico, como sujeto de derechos y obligaciones y sujeto capaz de relaciones jurídicas. El reconocimiento de dicha personalidad jurídica juega un papel decisivo, especialmente, en el ámbito patrimonial, porque confiere a la entidad capacidad para adquirir, administrar y enajenar bienes con plena eficacia jurídica. El presente trabajo analiza los requisitos necesarios para el reconocimiento de la personalidad jurídica civil de las fundaciones erigidas canónicamente por la Iglesia Católica.Legal personality is a necessary instrument for a particular entity, be it associative or proprietary, enabling it to act within the legal system as a subject with rights and obligations and capable of forming legal relationships. The recognition of legal personality plays a decisive role especially in proprietary contexts, because it confers on the entity the capacity to acquire, administer and dispose of goods with full legal efficacy. The present study analyzes the requirements for recognition of the civil legal personality of foundations created canonically by the Catholic Church

    Effect of zinc intake on growth in infants: A meta-analysis

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    A systematic review and meta-analysis of available randomized controlled trials (RCTs) was conducted to evaluate the effect of zinc (Zn) intake on growth in infants. Out of 5500 studies identified through electronic searches and reference lists, 19 RCTs were selected after applying the exclusion/inclusion criteria. The influence of Zn intake on growth was considered in the overall meta-analysis. Other variables were also taken into account as possible effect modifiers: doses of Zn intake, intervention duration, nutritional status, and risk of bias. From each select growth study, final measures of weight, length, mid upper arm circumference (MUAC), head circumference, weight for age z-score (WAZ), length for age z-score (LAZ), and weight for length z-score (WLZ) were assessed. Pooled β and 95% confidence interval (CI) were calculated. Additionally, we carried out a sensitivity analysis. Zn intake was not associated with weight, length, MUAC, head circumference, and LAZ in the pooled analyses. However, Zn intake had a positive and statistically effect on WAZ (β = 0.06; 95%CI 0.02 to 0.10) and WLZ (β = 0.05; 95%CI 0.01 to 0.08). The dose–response relationship between Zn intake and these parameters indicated that a doubling of Zn intake increased WAZ and WLZ by approximately 4%. Substantial heterogeneity was present only in length analyses (I2 = 45%; p = 0.03). Zn intake was positively associated with length values at short time (four to 20 weeks) (β = 0.01; CI 95% 0 to 0.02) and at medium doses of Zn (4.1 to 8 mg/day) (β = 0.003; CI 95% 0 to 0.01). Nevertheless, the effect magnitude was small. Our results indicate that Zn intake increases growth parameters of infants. Nonetheless, interpretation of these results should be carefully considered

    Thoracic Manifestations of Connective Tissue Diseases

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    Connective tissue diseases (CTDs) comprise several immunologic systemic disorders, each of which associated with a particular set of clinical manifestations and autoimmune profile. CTDs may cause numerous thoracic abnormalities, which vary in frequency and pattern according to the underlying disorder. The CTDs that most commonly involve the respiratory system are progressive systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis, Sjögren syndrome, polymyositis, dermatomyositis, and mixed connective tissue disease. Pulmonary abnormalities in this group of patients may result from CTD-related lung disease or treatment complications, namely drug toxicity and opportunistic infections. The most important thoracic manifestations of CTDs are interstitial lung disease and pulmonary arterial hypertension, with nonspecific interstitial pneumonia being the most common pattern of interstitial lung disease. High-resolution computed tomography is a valuable tool in the initial evaluation and follow-up of patients with CTDs. As such, general knowledge of the most common high-resolution computed tomographic features of CTD-related lung disease allows the radiologist to contribute to better patient management

    Stereochemical aspects and the synthetic scope of the SHi at the sulfur atom. Preparation of enantiopure 3-substituted 2,3-dihydro-1,2- benzoisothiazole 1-oxides and 1,1-dioxides

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    Intramolecular homolytic substitution (SHi) on the sulfur atom at acyclic N-(o-bromobenzyl)sulfinamides takes place with a complete inversion of the configuration and provides an excellent tool to connect N-tert-butanesulfinylimines with enantiopure 3-substituted benzo-fused sulfinamides (1,2-benzoisothiazoline 1-oxides) and the related pharmacologically relevant sulfonamidesThe Spanish Government (grant CTQ2012-35957) and Comunidad de Madrid (CCG08-UAM/PPQ-4151; S2009/PPQ1634
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