718 research outputs found

    In-vivo magnetic resonance imaging of hyperpolarized silicon particles

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    Silicon-based micro and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in-vivo, as well as a flexible surface chemistry, which allows drug loading, functionalization and targeting. Here we report direct in-vivo imaging of hyperpolarized 29Si nuclei in silicon microparticles by MRI. Natural physical properties of silicon provide surface electronic states for dynamic nuclear polarization (DNP), extremely long depolarization times, insensitivity to the in-vivo environment or particle tumbling, and surfaces favorable for functionalization. Potential applications to gastrointestinal, intravascular, and tumor perfusion imaging at sub-picomolar concentrations are presented. These results demonstrate a new background-free imaging modality applicable to a range of inexpensive, readily available, and biocompatible Si particles.Comment: Supplemental Material include

    Communication difficulties reported by patients diagnosed with idiopathic pulmonary fibrosis and their carers : a European focus group study

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    This paper explores commonalities in the experience and unmet needs of idiopathic pulmonary fibrosis (IPF) patients and carers in Europe throughout the care pathway, focusing specifically on the unmet communication needs of patients and carers. Four patient organisations/groups in Europe held focus groups (Italy (seven patients and four carers); Belgium (six patients); Ireland (23 patients and 10 carers); and England, UK (five patients and three carers)). A focus group schedule was provided and translated into the language of each focus group by the European Lung Foundation (ELF). Content analysis was conducted by the ELF and verified by the authors of the paper. Three main themes emerged: professional-patient, professional-professional and patient-patient communication. Within these themes, eight priority areas were highlighted by two or more of the focus groups. In addition, 17 suggested action points were identified. Patients and carers in Europe have unmet communication needs, which could be met by specialist physicians and specialist centres providing more effective information and signposting to support services, including support groups and patient organisations

    Muddying the waters: Impacts of a bogflow on carbon transport and water quality

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    Landslides of peat have been recorded throughout Britain and Ireland for centuries. Whilst these events are not uncommon, land degradation can amplify their magnitude and frequency and, crucially, their immediate impacts are rarely documented. A 20,000 m3 bogflow event that occurred on land undergoing development in the Irish border area in November 2020 was monitored at high frequency in the major receiving river system (384 km2). Samples collected every seven hours over a 28 day period at a site 37 km downstream were analysed for suspended sediment (SS), particulate organic carbon (POC) and dissolved organic carbon (DOC and UV-derived fractions), synchronous with hydrometeorological data and turbidity. There was no impact of the bogflow on DOC concentrations or loads. However, concentrations of SS and POC in the first samples after the bogflow were 825 mg/L and 346 mg C/L, respectively, and fish kill was estimated at 100 %. Analysis of detrended SS and POC loads suggested the main impacts of the bogflow on water quality lasted just eight days. Over this period, an additional 1318 t of SS and 608 t of POC were transported as far as the monitoring point, equating to 325 % more SS and 925 % more POC than would have been expected otherwise under the same river flow conditions. The carbon loss and water quality impacts were short lived, but nevertheless severe, and highlight the vulnerability of peatlands and the risks when these environments are inappropriately managed

    Pricing European Options with a Log Student's t-Distribution: a Gosset Formula

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    The distribution of the returns for a stock are not well described by a normal probability density function (pdf). Student's t-distributions, which have fat tails, are known to fit the distributions of the returns. We present pricing of European call or put options using a log Student's t-distribution, which we call a Gosset approach in honour of W.S. Gosset, the author behind the nom de plume Student. The approach that we present can be used to price European options using other distributions and yields the Black-Scholes formula for returns described by a normal pdf.Comment: 12 journal pages, 9 figures and 3 tables (Submitted to Physica A

    Antibodies against heart muscle and nuclear constituents in cardiomyopathy,

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    The prevalence of HAB and ANA was determined in eight patients with idiopathic hypertrophic subaortic stenosis (IHSS) and 35 patients with cardiomyopathy (CM). HAB was found in 88 per cent of patients with IHSS and in 17 per cent of those with CM. Antinuclear antibody was found in 63 per cent of patients with IHSS and 43 per cent of those with CM. Aging alone was not responsible for the high prevalence of ANA in the former group, but may be partly so in the latter. There was an increased tendency for women in both groups to have ANA. An increased serum concentration of IgM was also observed in women in the IHSS and CM groups. Serum concentrations of IgG and IgA, precipitating antibodies to nuclear constituents, rheumatoid factors, and a positive serologic test for syphilis were not increased in patients with idiopathic cardiomyopathy. Positivity to HAB and ANA did not remain constant and was not present frequently in sera in follow-up studies of these patients. No instance of a negative test becoming positive was recorded for either HAB or ANA. The high prevalence of ANA in patients with IHSS and CM and an increased prevalence of HAB in patients with IHSS may suggest that an autoimmune disturbance is operative in these forms of cardiomyopathy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34168/1/0000456.pd

    Pathogenic implications of age of onset in juvenile rheumatoid arthritis

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    An analysis of age of onset in juvenile rheumatoid arthritis was performed in the last 300 children seen in our clinic. There was a peak age of onset in girls at 1 to 3 years. Distribution of age of onset in boys was bimodal with the first peak at 2 years of age and the second at 9 years. There was no accentuation of frequency in either sex in the 10- to 14-year age group. The distribution of age of onset was bimodal in both monarticular and polyarticular onset of disease, but no particular modal age of onset was seen with systemic onset of disease. It is possible that these data reflect that JRA is not a homogeneous disease, or that there are age-sex related differences in host susceptibility or pathogenoc agents.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37725/1/1780180309_ftp.pd

    FAIRer Data through Digital Recording: The FAIMS Mobile Experience

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    Critical data and metadata must be captured or created in the field, or shortly thereafter, to avoid loss. For the past 10 years, the Field Acquired Information Management Systems (FAIMS) project has developed and operated a customisable field data capture platform. Over time, we built features and approaches that incorporated the Findable, Accessible, Interoperable, and Reusable (FAIR) principles into born-digital datasets created during fieldwork. This paper synthesises our experience helping more than 40 projects adapt the FAIMS platform to nearly 70 research workflows in archaeology and other fieldwork domains. We review what elements of the FAIR Data Principles FAIMS was able to build into our software, how users received these capabilities, and what sociotechnical challenges impeded creation of FAIRer field data. Based on our experience, we argue that field data capture software can facilitate the production of FAIRer data, making those data much more Findable and Reusable, and somewhat more Accessible and Interoperable. Any such improvements, however, depend upon (1) making FAIR-data features an integral part of field data collection systems, minimising the burden imposed on researchers, and (2) researchers’ willingness to spend time and resources implementing FAIR Data Principles that do not provide immediate benefits to their research
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