Table_2_Impact of Immediacy of Feedback on Continuous Intentions to Use Online Learning From the Student Perspective.DOCX

The immediacy of feedback in media is emerging to enhance the interactivity of online experience for users. There is a gap in the study to explore the impacts of the immediacy of feedback on continuous intentions to use online learning from the student perspective. This study aims to fill the gap to investigate the impacts of the immediacy of feedback on students’ continuous intentions to use online learning. This study utilizes the technology acceptance model (TAM) and expectation theory model (ETM) to conceptualize the effect of the immediacy of feedback on student continuous intentions to use online learning in terms of the mediation effect of Perceived Ease of Use (PEOU), Perceived Usefulness (PU), satisfaction, and attitude of students for continuous intentions to use online learning. An online survey of higher education students with experience in online learning is conducted to test the proposed hypothesis. The collected data are analyzed by using structural equation modeling (SEM) to establish the proposed hypothesis. The findings reveal that the immediacy of feedback from the media has a strong association with PEOU, PU, students’ attitudes, students’ satisfaction, and ultimately toward the continuous intentions to use online line learning in future. The study set key theoretical and practical insights to pave the way for future research.</p

Data_Sheet_1_ESL/EFL Learners' Responses to Teacher Written Feedback: Reviewing a Recent Decade of Empirical Studies.docx

Teacher written feedback (TWF) has long been regarded as a necessary pedagogical tool for improving the writing proficiency of ESL/EFL learners, while student responses to this feedback can often reflect its effectiveness. This paper reviews 64 articles appearing in high-ranking journals during 2010–2021 in terms of research methodology, theoretical framework and main findings. Analysis of these articles reveals few studies adopted any theoretical frameworks to examine learner responses to TWF and suggests a need for longitudinal naturalistic studies adopting mixed methods and some theoretical framework such as sociocultural theory of mind (SCT) to better explain learners' dynamic engagement in response to TWF. The main findings of these previous studies reveal the diverse responses among learners at different language proficiency levels and in various sociocultural contexts. The results of the review indicate that future research could take classroom-based mixed-method research design to investigate learner variables.</p

Table_1_Impact of Immediacy of Feedback on Continuous Intentions to Use Online Learning From the Student Perspective.XLSX

The immediacy of feedback in media is emerging to enhance the interactivity of online experience for users. There is a gap in the study to explore the impacts of the immediacy of feedback on continuous intentions to use online learning from the student perspective. This study aims to fill the gap to investigate the impacts of the immediacy of feedback on students’ continuous intentions to use online learning. This study utilizes the technology acceptance model (TAM) and expectation theory model (ETM) to conceptualize the effect of the immediacy of feedback on student continuous intentions to use online learning in terms of the mediation effect of Perceived Ease of Use (PEOU), Perceived Usefulness (PU), satisfaction, and attitude of students for continuous intentions to use online learning. An online survey of higher education students with experience in online learning is conducted to test the proposed hypothesis. The collected data are analyzed by using structural equation modeling (SEM) to establish the proposed hypothesis. The findings reveal that the immediacy of feedback from the media has a strong association with PEOU, PU, students’ attitudes, students’ satisfaction, and ultimately toward the continuous intentions to use online line learning in future. The study set key theoretical and practical insights to pave the way for future research.</p

Subangstrom Profile Imaging of Relaxed ZnO(101̅0) Surfaces

Relaxation is a most basic structural behavior of free surfaces, however, direct observation of surface relaxation remains challenging in atomic-scale. Herein, single-crystalline nanoislands formed in situ on ZnO nanowires and nanobelts are characterized using aberration-corrected transmission electron microscopy combined with ab initio calculations. For the first time, displacements of both Zn and O atoms in the fresh (101̅0) facets are quantified to accuracies of several picometers and the under-surface distributions of contractions and rotations of Zn–O bonds are directly measured, which unambiguously verify the theoretically predicted relaxation of ZnO (101̅0) free surfaces. Finally, the surface relaxation is directly correlated with the size effects of electromechanical properties (e.g., elastic modulus and spontaneous polarization) in ZnO nanowires

Iron-Catalyzed Tandem Oxidative Coupling and Annulation: An Efficient Approach to Construct Polysubstituted Benzofurans

The combination of FeCl3·6H2O and di-tert-butyl peroxide offers a novel and efficient method for the construction of polysubstituted benzofurans 3 from the reaction of simple phenols 1 and β-keto esters 2, which are expected to give coumarins in the well-known Pechmann condensation. A variety of phenols reacted with β-keto esters to provide a range of benzofuran products in moderate to excellent yields. The regio-specific annulation was proven by the X-ray molecular structure of the product 3k. Hydrate of FeCl3 is essential for an achievement of the present transformation. The kinetic isotopic effect (KIE) experiments were carried out by competition experiments and displayed a kH/kD = 1.0 ± 0.1. The kinetic isotopic effect indicated that aromatic C−H bond cleavage is not involved in the rate-determining steps of the present transformation. Moreover, the results clearly demonstrate that the dichotomous catalytic behavior of the iron catalyst, which is transition-metal catalyst in the oxidative coupling step and Lewis acid in the condensation step. The possible intermediate 5 was synthesized and converted into the desired benzofuran 3a under the reaction conditions. A tentative mechanism of the formation of benzofurans 3 was proposed

DataSheet1_Roles of 21 Genera of Human Gut Microbiota in Barrett’s Esophagus Risk: A Mendelian Randomization Study.docx

Background: Lack of definitive evidence supports the putative hypothesis that gut microbiota dysbiosis is associated with Barrett’s esophagus (BE). We conducted a two-sample Mendelian randomization study to assess the associations of 21 genera of human gut microbiota with BE.Methods: We identified independent genetic instruments for 21 genera of gut microbiota (including nine dominant genera, four core genera among individuals of European ancestry, and eight esophagus-specific genera of gut microbiota) from MiBioGen (up to 18,340 participants). We applied them to summary statistics from the largest publicly available genome-wide association study on BE (9,680 cases and 31,211 controls). We obtained the causal estimates of genetically predicted higher genera of gut microbiota and BE using the inverse variance weighting method. Sensitivity analyses included weighted median, MR-Egger, MR-RAPS, and MR-PRESSO.Results: We found that genetically predicted higher Actinomyces (OR: 0.76 per unit increase in log odds of having BE, 95% CI: 0.70–0.83) and higher Ruminiclostridium (OR: 0.75, 95% CI: 0.63–0.90) were significantly associated with a lower risk of BE. No associations of other genera of gut microbiota with BE were noted, apart from suggestive associations of higher Alistipes (OR: 0.77; 95% CI: 0.61–0.99), higher Eubacterium (OR: 0.89; 95% CI: 0.80–0.99), and higher Veillonella (OR: 0.76; 95% CI: 0.56–1.02) with a lower risk of BE, and higher Faecalibacterium (OR: 1.15; 95% CI: 0.99–1.33) with a higher risk of BE.Conclusion: This study suggests that higher Actinomyces and higher Ruminiclostridium might protect against BE.</p

Iron-Catalyzed Tandem Oxidative Coupling and Annulation: An Efficient Approach to Construct Polysubstituted Benzofurans

The combination of FeCl3·6H2O and di-tert-butyl peroxide offers a novel and efficient method for the construction of polysubstituted benzofurans 3 from the reaction of simple phenols 1 and β-keto esters 2, which are expected to give coumarins in the well-known Pechmann condensation. A variety of phenols reacted with β-keto esters to provide a range of benzofuran products in moderate to excellent yields. The regio-specific annulation was proven by the X-ray molecular structure of the product 3k. Hydrate of FeCl3 is essential for an achievement of the present transformation. The kinetic isotopic effect (KIE) experiments were carried out by competition experiments and displayed a kH/kD = 1.0 ± 0.1. The kinetic isotopic effect indicated that aromatic C−H bond cleavage is not involved in the rate-determining steps of the present transformation. Moreover, the results clearly demonstrate that the dichotomous catalytic behavior of the iron catalyst, which is transition-metal catalyst in the oxidative coupling step and Lewis acid in the condensation step. The possible intermediate 5 was synthesized and converted into the desired benzofuran 3a under the reaction conditions. A tentative mechanism of the formation of benzofurans 3 was proposed

Thermal Wetting of Platinum Nanocrystals on Silica Surface

Thermal stability of facetted Pt nanocrystals on amorphous silica support films was investigated using in situ transmission electron microscopy in a temperature range between 25 and 800 °C. The particles started to change their shapes at ∼350 °C. Above 500 °C, the particles spread on the support film with increasing temperature, rather than becoming more spherical. Such temperature-induced wetting of Pt nanoparticles on silica surface can be attributed to the interfacial mixing of Pt and SiO2 and the resulting negative interface energy

Strain Concentration at the Boundaries in 5‑Fold Twins of Diamond and Silicon

Widely found in metals, semiconductors, oxides, and even organic materials, multiple twinning has important implications in engineering applications of materials. In this work, the intrinsic strain in 5-fold twins of diamond and silicon has been studied combining aberration-corrected electron microscopy and first-principles calculations. In contrast to metallic 5-fold twins, where the strain distribution is relatively smooth, the semiconductor systems show significant strain concentration at the twin boundaries, which is shear modulus dependent. In silicon with moderate strain concentration, the electronic frontier orbitals are located at the center of the 5-fold twins. Accompanying the increased strain concentration in diamond, however, the frontier orbitals are pushed to the surface. The modification of strain state and surface electronic structure by materials elasticity suggest possible routes to tune catalytic, electronic, and mechanical properties of materials

Data_Sheet_1_Case report: Whole-exome sequencing identifies a novel DES mutation (p. E434K) in a Chinese family with cardiomyopathy and sudden cardiac death.xls

BackgroundDesmin is an intermediate filament protein that plays a critical role in the stabilization of the sarcomeres and cell contacts in the cardiac intercalated disk. Mutated DES gene can cause hereditary cardiomyopathy with heterogeneous phenotypes, while the underlying molecular mechanisms requires further investigation.MethodsWe described a Chinese family present with cardiomyopathy and sudden cardiac death (SCD). Whole-exome sequencing (WES) and bioinformatics strategies were employed to explore the genetic entity of this family.ResultsAn unknown heterozygote missense variant (c.1300G > A; p. E434K) of DES gene was identified. The mutation cosegregates in this family. The mutation was predicted as pathogenic and was absent in our 200 healthy controls.ConclusionWe identified a novel DES mutation (p. E434K) in a Chinese family with cardiomyopathy and SCD. Our study not only provided a new case for the study of the relationship between DES mutations and hereditary cardiomyopathy but also broadened the spectrum of DES mutations.</p