Perancangan Dan Pembuatan Aplikasi Ecommerce Pada Toko Agung Jaya

Perkembangan teknologi pada saat ini telah berkembang secara pesat. Dimana hampir semua kegiatan dapat dilakukan pada dunia maya, misalnya melakukan transaksi pembayaran, pembelian barang, pemesanan tiket, baik tiket pesawat maupun tiket kereta api, dan lainnya.Di jaman sekarang ini penjualan secara online sudah banyak. Hal ini dikarenakan untuk membuka suatu USAha online lebih mudah dan murah dari pada membuka USAha disuatu tempat yang berbentuk bangunan. Selain itu, dengan cara berjualan online orang akan lebih banyak mengetahui barang apa saja yang dijual, karena semua orang dapat melihat tanpa harus mendatangi tempat itu.Berdasarkan hasil pengujian aplikasi yang telah dibuat, aplikasi dapat menampilkan data barang yang dijual beserta promo yang ditawarkan. Selain itu aplikasi ini mempunyai fitur konfirmasi account untuk mengaktifkan account dan kirim detail order

Marriage by Age Groups in China, Japan, and Korea.

<p>10-year age groups in which “younger than 20 (-20)” in Japan includes only those who are 20. Numbers in bars indicate percentage of married/unmarried individuals in each country.</p

Predicted Marriage Protection Effects with Age.

<p>Rows correspond to health indicators, columns to countries. Blue line denotes health of married respondents, and red line denotes health for unmarried respondents.</p

Education Concordances by Gender in China, Japan, and Korea.

<p>Percentages in bars indicate corresponding ratios of intra-couple concordance of educational achievement by gender in each country.</p

Comparative Age Structures in China, Japan, and Korea.

<p>10-year age groups in which “younger than 20 (-20)” in Japan includes only those who are 20. Numbers in bars indicate corresponding numbers of observation.</p

DataSheet1_A seamless approach for evaluating climate models across spatial scales.PDF

In regions of the world where topography varies significantly with distance, most global climate models (GCMs) have spatial resolutions that are too coarse to accurately simulate key meteorological variables that are influenced by topography, such as clouds, precipitation, and surface temperatures. One approach to tackle this challenge is to run climate models of sufficiently high resolution in those topographically complex regions such as the North American Regionally Refined Model (NARRM) subset of the Department of Energy’s (DOE) Energy Exascale Earth System Model version 2 (E3SM v2). Although high-resolution simulations are expected to provide unprecedented details of atmospheric processes, running models at such high resolutions remains computationally expensive compared to lower-resolution models such as the E3SM Low Resolution (LR). Moreover, because regionally refined and high-resolution GCMs are relatively new, there are a limited number of observational datasets and frameworks available for evaluating climate models with regionally varying spatial resolutions. As such, we developed a new framework to quantify the added value of high spatial resolution in simulating precipitation over the contiguous United States (CONUS). To determine its viability, we applied the framework to two model simulations and an observational dataset. We first remapped all the data into Hierarchical Equal-Area Iso-Latitude Pixelization (HEALPix) pixels. HEALPix offers several mathematical properties that enable seamless evaluation of climate models across different spatial resolutions including its equal-area and partitioning properties. The remapped HEALPix-based data are used to show how the spatial variability of both observed and simulated precipitation changes with resolution increases. This study provides valuable insights into the requirements for achieving accurate simulations of precipitation patterns over the CONUS. It highlights the importance of allocating sufficient computational resources to run climate models at higher temporal and spatial resolutions to capture spatial patterns effectively. Furthermore, the study demonstrates the effectiveness of the HEALPix framework in evaluating precipitation simulations across different spatial resolutions. This framework offers a viable approach for comparing observed and simulated data when dealing with datasets of varying spatial resolutions. By employing this framework, researchers can extend its usage to other climate variables, datasets, and disciplines that require comparing datasets with different spatial resolutions.</p

DS_10.1177_0022146518824566 – Supplemental material for Intergenerational Association of Maternal Obesity and Child Peer Victimization in the United States

Supplemental material, DS_10.1177_0022146518824566 for Intergenerational Association of Maternal Obesity and Child Peer Victimization in the United States by Miao Li, Rong Fu, Hong Xue and Youfa Wang in Journal of Health and Social Behavior</p

EPR and Mössbauer Spectroscopy Show Inequivalent Hemes in Tryptophan Dioxygenase

Tryptophan 2,3-dioxygenase (TDO) is an essential enzyme in the pathway of NAD biosynthesis and important for all living organisms. TDO catalyzes oxidative cleavage of the indole ring of L-tryptophan (l-Trp), converting it to N-formylkynurenine (NFK). The crystal structure of TDO shows a dimer of dimer quaternary structure of the homotetrameric protein. The four catalytic sites of the protein, one per subunit, contain a heme that catalyzes the activation and insertion of dioxygen into l-Trp. Because of the α4 structure and because only one type of heme center has been identified in previous spectroscopic studies, the four hemes sites have been presumed to be equivalent. The present work demonstrates that the heme sites of TDO are not equivalent. Quantitative interpretation of EPR and Mössbauer spectroscopic data indicates the presence of two dominant inequivalent heme species in reduced and oxidized states of the enzyme, which is consistent with a dimer of dimer protein quaternary structure that now extends to the electronic properties of the hemes. The electronic properties of the hemes in the reduced state of TDO change significantly upon l-Trp addition, which is attributed to a change in the protonation state of the proximal histidine to the hemes. The binding of O2 surrogates NO or CO shows two inequivalent heme sites. The heme−NO complexes are 5- and 6-coordinate without l-Trp, and both 6-coordinate with l-Trp. NO can be selectively photodissociated from only one of the heme−NO sites and only in the presence of l-Trp. Cryoreduction of TDO produces a novel diamagnetic heme species, tentatively assigned as a reduced heme-OH complex. This work presents a new description of the heme interactions with the protein, and with the proximal His, which must be considered during the general interpretation of physical data as it relates to kinetics, mechanism, and function of TDO

Heme Iron Nitrosyl Complex of MauG Reveals an Efficient Redox Equilibrium between Hemes with Only One Heme Exclusively Binding Exogenous Ligands

MauG is a diheme enzyme that oxidizes two protein-bound tryptophan residues to generate a catalytic tryptophan tryptophylquinone cofactor within methylamine dehydrogenase. Upon the two-electron oxidation of bis-ferric MauG, the two c-type hemes exist as a spin-uncoupled bis-Fe(IV) species with only one binding oxygen, which is chemically equivalent to a single ferryl heme plus a π porphyrin cation radical (Li, X. et al. (2008) Proc. Natl. Acad. Sci. U.S.A.105, 8597−8600). The EPR spectrum of the nitrosyl complex of fully reduced MauG shows a single six-coordinate Fe(II)-NO species, which is characteristic of a histidine-ligated Fe(II)-NO moiety in the heme environment. Exposure of partially reduced MauG to NO reveals a redox equilibrium with facile electron transfer between hemes but with only one binding nitric oxide. Thus, the second heme is able to stabilize all three redox states of iron (Fe(II), Fe(III), and Fe(IV)) in a six-coordinate protein-bound heme without binding exogenous ligands. This is unprecedented behavior for a protein-bound heme for which each of these redox states is relevant to the overall catalytic mechanism. The results also illustrate the electronic communication between the two iron centers, which function as a diheme unit rather than independent heme cofactors

Table_2_Partial SAA patients benefit from delayed response of IST.docx

IntroductionSevere aplastic anemia(SAA)is a severe disease characterized by immune-mediated bone marrow failure and pancytopenia. Immunosuppressive therapy (ATG plus CsA, IST) is the standard treatment for patients who are not suitable for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Some patients have a delayed response after 6 months of ATG, and unnecessary to be given secondary ATG or allo-HSCT. We attempted to distinguish patients who may get potential delayed response from those who were really not responsive to IST.MethodsWe collected data from 45 SAA patients who were assessed no-response to IST at 6 months after rATG and failed to receive secondary ATG or allo-HSCT.ResultsCsA plus eltrombopag (EPAG) group has an extra 75% response rate while CsA maintenance group has an extra 44% response rate at 12 months. ATG was applied within 30 days after diagnosis, ATG dosage was suffificient (ATG/lymphocyte ≥2), and absolute reticulocyte count (ARC) was ≥30×109 /L at 6 months, indicated patients could get delayed response and benefifit from CsA maintenance. Addition of EPAG could give an even better response. Otherwise, secondary ATG or allo-HSCT treatment were recommended to be given immediately.Clinical Trial Registrationhttps://www.chictr.org.cn/searchproj.aspx, identifier ChiCTR2300067615.</p