Adverse events reported among chronic hepatitis C patients treated at a single centre in Germany.

Adverse events reported among chronic hepatitis C patients treated at a single centre in Germany.</p

Proportion achieving SVR12 among SOF/VEL patients overall, and by genotype treated at a single centre in Germany.

GT1: genotype 1; GT2: genotype 2; GT3: genotype 3; GT4: genotype 4; GT5: genotype 5; GT6: genotype 6; SVR12: sustained virologic response at 12 weeks. 1One patient did not achieve SVR with the following characteristics; male, 69 years old, white, GT1a, F4-CC and TN.</p

Real-world effectiveness and safety of sofosbuvir/velpatasvir and ledipasvir/sofosbuvir hepatitis C treatment in a single centre in Germany

BackgroundNewer direct-acting antiviral therapies are increasingly becoming the therapy of choice in patients with hepatitis C virus (HCV) infection. Here, we report the safety and effectiveness of sofosbuvir/velpatasvir (SOF/VEL) and ledipasvir/sofosbuvir (LDV/SOF) in real-world cohorts in Germany.MethodsPatients initiated on SOF/VEL 12 weeks or LDV/SOF 8, 12 or 24 weeks regimens in a single German centre were included in this study. Data on treatment outcomes and adverse events (AE) were analysed in patients with available sustained virologic response 12 weeks after cessation of treatment (SVR12) information overall and by subgroups.ResultsThis study included 115 patients who received SOF/VEL from July-2016 to July-2017, and 249 patients who received LDV/SOF from November-2014 to September-2015. Overall, SVR12 was achieved in 99% of patients on SOF/VEL ± ribavirin 12 weeks independent of HCV genotype, treatment history, or cirrhosis status, and in 96% of patients treated with LDV/SOF 8 weeks or LDV/SOF ± ribavirin 12 or 24 weeks. In genotype 1 treatment-naïve, non-cirrhotic patients, ≥99% achieved SVR12 across SOF/VEL and LDV/SOF regimens. Likewise, 100% of genotype 3-cirrhotic patients on SOF/VEL ± ribavirin regimens achieved SVR12. Grade 3/4 AE were reported in 13 (5.2%) patients on LDV/SOF and in 1 (ConclusionOverall, SOF/VEL and LDV/SOF achieved high SVR rates in a broad patient population. We showed the effectiveness of SOF/VEL as a pan-genotypic regimen, and regardless of treatment history or cirrhosis status. Use of such therapies improves outcomes and contributes towards the global efforts to eradicate HCV.</div

Proportion achieving SVR12 among GT1, treatment-naïve, non-cirrhotic patients on LDV/SOF or SOF/VEL treated at a single centre in Germany.

LDV: ledipasvir; SOF: sofosbuvir; SVR12: sustained virological response at 12 weeks; VEL: velpatasvir.</p

Baseline characteristics of chronic hepatitis C patients treated at a single centre in Germany.

Baseline characteristics of chronic hepatitis C patients treated at a single centre in Germany.</p