Overall survival (OS) according to the publications before and after 1980.

<p>A modest increase in treatment success has been achieved over recent decades.</p

Impact of age on overall survival (OS).

<p>On univariate analysis the older patients (≥ 60 years at initial diagnosis) had significantly shorter survival times (p < 0.0001).</p

Clinical Characteristics of ….

<p>Clinical Characteristics of ….</p

Kaplan-Meier Plot PFS.

<p>Kaplan-Meier Plot PFS.</p

Procedure of publication retrieval and in- and exclusion of cases displayed in a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow chart (4).

<p>Procedure of publication retrieval and in- and exclusion of cases displayed in a PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow chart (4).</p

Age distribution of 157 patients with primary spinal origin reported in literature until March 2015.

<p>It is displayed in the form of a histogram. Median age at diagnosis was 22 years.</p

Cox Regression.

<p>Cox Regression.</p

Kaplan-Meier Plot OS.

<p>Kaplan-Meier Plot OS.</p

Limitation of this study - non-English articles.

<p>Note: n/s – not specified; y/n – yes/no.</p>a<p>Provided by title of the article or abstract if available.</p

Initial symptoms and radiology features.

<p>Initial symptoms and radiology features.</p