PENDEKATAN METODE TRIGONOMETRI PADA APLIKASI PEMANTAUAN PROGRES PEMBANGUNAN JALAN BERBASIS ANDROID

The construction industry such as road construction deals with many problems and uncertainty in the implementation process. In addition, time, cost and quality of work issues are also the focus of project implementation in the field of research services, It starts with the data planning and location coordinates which are aggregated from the project's site by the officer. Those data planning and location coordinates are pin pointed and stored in databases. each point consists of Longitude, Latitude, Road type, and road width. Using the Android application for monitoring, the officer conducts the supervision as required for the determined point in order to update the road construction status, the trigonometric process will directly display the right and left lines for the direction of the photo capturing. however, a long road capturing, the system will take approximately 30 seconds so that GPS can read coordinates correctlyIndustri konstruksi seperti pembangunan jalan tentunya akan memiliki banyak risiko dan ketidak pastian dalam proses pelaksanaannya bila dibandingkan dengan industri lainnya. Selain terkendala masalah waktu, biaya dan mutu pekerjaan juga menjadi kendala pada setiap pelaksanaan proyek di bidang jasa konstruksi Penelitian ini dimulai dengan pengumpulan data keadaan dan perencaan di lapangan yang di input oleh petugas pemerintahan. Semua titik pembangunan di simpan dalam database. menggunakan aplikasi android untuk monitoring, petugas yang melakukan pengawasan diperlukan untuk berada di titik yang telah di tentukan untuk dapat memperbaharui status pembangunan jalan pada titik tersebut. Pada pengambilan gambar, proses trigonometri akan langsung menampilkan outline jalan lurus, berbelok 9

C17 Prevents Inflammatory Arthritis and Associated Joint Destruction in Mice

C17 was first described about ten years ago as a gene expressed in CD34+ cells. A more recent study has suggested a role for C17 in chondrogenesis and development of cartilage. However, based on sequence analysis, we believe that C17 has homology to IL-2 and hence we present the hypothesis that C17 is a cytokine possessing immune-regulatory properties. We provide evidence that C17 is a secreted protein preferentially expressed in chondrocytes, hence in cartilage-rich tissues. Systemic expression of C17 in vivo reduces disease in a collagen antibody-induced arthritis model in mice (CAIA). Joint protection is evident by delayed disease onset, minimal edema, bone protection and absence of diverse histological features of disease. Expression of genes typically associated with acute joint inflammation and erosion of cartilage or bone is blunted in the presence of C17. Consistent with the observed reduction in bone erosion, we demonstrate reduced levels of RANKL in the paws and sera of mice over-expressing C17. Administration of C17 at the peak of disease, however, had no effect on disease progression, indicating that C17's immune-regulatory activity must be most prominent prior to or at the onset of severe joint inflammation. Based on this data we propose C17 as a cytokine that s contributes to immune homeostasis systemically or in a tissue-specific manner in the joint

Altered Responses to Homeostatic Cytokines in Patients with Idiopathic CD4 Lymphocytopenia

Idiopathic CD4 lymphocytopenia (ICL) is a rare immune deficiency characterized by a protracted CD4+ T cell loss of unknown etiology and by the occurrence of opportunistic infections similar to those seen in AIDS. We investigated whether a defect in responses to cytokines that control CD4+ T cell homeostasis could play a role in ICL. Immunophenotype and signaling responses to interleukin-7 (IL-7), IL-2, and thymic stromal lymphopoietin (TSLP) were analyzed by flow cytometry in CD4+ T cells from 15 ICL patients and 15 healthy blood donors. The induction of phospho-STAT5 after IL-7 stimulation was decreased in memory CD4+ T cells of some ICL patients, which correlated with a decreased expression of the IL-7R\uce\ub1 receptor chain (R = 0.74, p<0.005) and with lower CD4+ T cell counts (R = 0.69, p<0.005). IL-2 responses were also impaired, both in the Treg and conventional memory subsets. Decreased IL-2 responses correlated with decreased IL-7 responses (R = 0.75, p<0.005), pointing to combined defects that may significantly perturb CD4+ T cell homeostasis in a subset of ICL patients. Unexpectedly, responses to the IL-7-related cytokine TSLP were increased in ICL patients, while they remained barely detectable in healthy controls. TSLP responses correlated inversely with IL-7 responses (R = -0.41; p<0.05), suggesting a cross-regulation between the two cytokine systems. In conclusion, IL-7 and IL-2 signaling are impaired in ICL, which may account for the loss of CD4+ T cell homeostasis. Increased TSLP responses point to a compensatory homeostatic mechanism that may mitigate defects in \uce\ub3c cytokine responses. \uc2\ua9 2013 Bugault et al

The Tumor-Immune Microenvironment and Response to Radiation Therapy

Chemotherapy and radiation therapy (RT) are standard therapeutic modalities for patients with cancer, including breast cancer. Historic studies examining tissue and cellular responses to RT have predominantly focused on damage caused to proliferating malignant cells leading to their death. However, there is increasing evidence that RT also leads to significant alterations in the tumor microenvironment, particularly with respect to effects on immune cells infiltrating tumors. This review focuses on tumor-associated immune cell responses following RT and discusses how immune responses may be modified to enhance durability and efficacy of RT

Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder associated with allergic hypersensitivity to food. We interrogated >1.5 million genetic variants in European EoE cases and subsequently in a multi-site cohort with local and out-of-study control subjects. In addition to replication of the 5q22 locus (meta-analysis p = 1.9×10−16), we identified association at 2p23 (encoding CAPN14, p = 2.5×10−10). CAPN14 was specifically expressed in the esophagus, dynamically upregulated as a function of disease activity and genetic haplotype and after exposure of epithelial cells to IL-13, and located in an epigenetic hotspot modified by IL-13. There was enriched esophageal expression for the genes neighboring the top 208 EoE sequence variants. Multiple allergic sensitization loci were associated with EoE susceptibility (4.8×10−2 < p < 5.1×10−11). We propose a model that elucidates the tissue specific nature of EoE that involves the interplay of allergic sensitization with an EoE-specific, IL-13–inducible esophageal response involving CAPN14

Realizing the Community Participation of Batik Craftsmen in Sustainable Development in Tampo Village, Banyuwangi Regency

The development of a village can be built with the role of government and community participation. Tampo Village, Banyuwangi Regency is one of the villages with the potential for famous Banyuwangi batik craftsmen. Community participation is one of the capitals for a village to improve its economic development of a village. Sustainable development is one of the elements that encourage village development. This study uses descriptive qualitative research methods, namely analyzing qualitative data to explain how to build community participation in realizing sustainable development in Tampo Village with Potential as a Batik Tourism Village. Data collection was done by field observations, in-depth interviews, and documentation. As one of the possible villages, the role of community participation has not been implemented properly. The existence of the association has not helped the development of the village so much. Therefore, it is necessary to strengthen how to build a community of batik craftsmen as a form of community participation. requires local government and community support to realize sustainable development in Tampo Village, Banyuwangi Regency

Little Words Their History, Phonology, Syntax, Semantics, Pragmatics, and Acquisition

Little Words is an interdisciplinary examination of the functions and change in the use of clitics, pronouns, determiners, conjunctions, discourse particles, auxiliary/light verbs, prepositions, and other "little words" that have played a central role in linguistic theory and in language acquisition research.Intro -- Contents -- List of Illustrations -- Preface -- Chapter 1. Introduction -- PART I: HISTORY -- Chapter 2. From "Two" to "Both": Historical Changes in the Syntax and Meaning of Oba in Slavic -- Chapter 3. When Small Words Collide: Morphological Reduction and Phonological Compensation in Old Leonese Contractions -- PART II: PHONOLOGY -- Chapter 4. Distinguishing Function Words from Content Words in Children's Oral Reading -- Chapter 5. Motivating Floating Quantifiers -- PART III: SYNTAX -- Chapter 6. Applicative Phrases Hosting Accusative Clitics -- Chapter 7. The Little DE of Degree Constructions -- Chapter 8. The Complementizer The -- Chapter 9. What Is There When Little Words Are Not There ?: Possible Implications for Evolutionary Studies -- Chapter 10. Spanish Personal a and the Antidative -- PART IV: SEMANTICS -- Chapter 11. Predicting Argument Realization from Oblique Marker Semantics -- Chapter 12. Aspect Selectors, Scales, and Contextual Operators: An Analysis of by Temporal Adjuncts -- Chapter 13. Distributive Effects of the Plural Marker -tul in Korean -- PART V: PRAGMATICS -- Chapter 14. The Pragmatics of the French Discourse Markers donc and alors -- Chapter 15. "Little Words" in Small Talk: Some Considerations on the Use of the Pragmatic Markers man in English and macho/tío in Peninsular Spanish -- Chapter 16. Little Words That Could Impact One's Impression on Others: Greetings and Closings in Institutional E-mails -- PART VI: ACQUISITION -- Chapter 17. Instructed L2 Acquisition of Differential Object Marking in Spanish -- Chapter 18. The Role of Pedagogical Tasks and Focus on Form in Acquisition of Discourse Markers by Advanced Language Learners -- Chapter 19. Article Acquisition in English, German, Norwegian, and Swedish -- Chapter 20. A Continuum in French Children's Surface Realization of AuxiliariesLittle Words is an interdisciplinary examination of the functions and change in the use of clitics, pronouns, determiners, conjunctions, discourse particles, auxiliary/light verbs, prepositions, and other "little words" that have played a central role in linguistic theory and in language acquisition research.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries

WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways.

IL-27 is an important and non-redundant regulator of effector T cell accumulation in non-lymphoid tissues during infection. Using malaria as a model systemic pro-inflammatory infection, we demonstrate that the aberrant accumulation of CD4⁺ T cells in the liver of infected IL27R(-/-) (WSX-1(-/-)) mice is a result of differences in cellular recruitment, rather than changes in T cell proliferation or cell death. We show that IL-27 both inhibits the migratory capacity of infection-derived CD4⁺ T cells towards infection-derived liver cells, but also suppresses the production of soluble liver-derived mediator(s) that direct CD4⁺ T cell movement towards the inflamed tissue. Although CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4⁺ T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice, migration of CD4⁺ T cells to the liver of WSX-1(-/-) mice during infection was not controlled by chemokine (R) signalling. However, anti-IL-12p40 treatment reduced migration of CD4⁺ T cells towards infection-derived liver cells, primarily by abrogating the hepatotropic migratory capacity of T cells, rather than diminishing soluble tissue-derived migratory signals. These results indicate that IL-27R signalling restricts CD4⁺ T cell accumulation within the liver during infection primarily by suppressing T cell chemotaxis, which may be linked to its capacity to repress Th1 differentiation, as well as by inhibiting the production of soluble, tissue-derived chemotaxins