Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy-2

<p><b>Copyright information:</b></p><p>Taken from "Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy"</p><p>http://www.biomedcentral.com/1471-2164/8/268</p><p>BMC Genomics 2007;8():268-268.</p><p>Published online 7 Aug 2007</p><p>PMCID:PMC1964766.</p><p></p>ted pathways are: Oxidative Phosphorylation (cluster 1), containing 16 genes downregulated in trisomic samples, and Focal Adhesion (cluster 2), containing at least 7 genes upregulated in trisomic samples. Cluster 3 is a network of Cell Adhesion genes, mostly upregulated in trisomic samples. Downregulated genes in cluster 1 are all mitochondrial genes; upregulated genes in clusters 2 and 3 are mostly ECM genes. Green indicates downregulated genes (darker green = more downregulated); red indicates upregulated genes (darker red = more upregulated)

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy-1

<p><b>Copyright information:</b></p><p>Taken from "Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy"</p><p>http://www.biomedcentral.com/1471-2164/8/268</p><p>BMC Genomics 2007;8():268-268.</p><p>Published online 7 Aug 2007</p><p>PMCID:PMC1964766.</p><p></p>rom the t-test is represented on the y-axis. Genes upregulated in the trisomic samples are on the right of the horizontal axis 0 value; genes downregulated are on the left. Red dots indicate 473 genes that are significantly up- or down-regulated in the trisomic samples compared to the control samples (p < 0.05). Yellow dots indicate genes with no significant variation

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy-3

<p><b>Copyright information:</b></p><p>Taken from "Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy"</p><p>http://www.biomedcentral.com/1471-2164/8/268</p><p>BMC Genomics 2007;8():268-268.</p><p>Published online 7 Aug 2007</p><p>PMCID:PMC1964766.</p><p></p>H4, CDH5, CDH6 and DH1, DH3, DH4, DH5, DH6) and individual normal hearts (H1, H2, H3, H4, H5) show an inverse correlation (r = -066) between the two genes