Heavy Hadrons in Dense Matter

We study the behavior of dynamically-generated baryon resonances with heavy-quark content within a unitarized coupled-channel theory in matter that fulfills heavy-quark spin symmetry constraints. We analyze the implications for the formation of charmed mesic nuclei and the propagation of heavy mesons in heavy-ion collisions from RHIC to FAIR.Comment: 4 pages, 1 table, 2 figures, contribution to the proceedings of Strangeness in Quark Matter (SQM2015), Dubna, 6-11 July 201

AFECTACIÓN DE LOS TRASTORNOS DEL SUEÑO EN LA CALIDAD DE VIDA DE LOS POLICÍAS

El objetivo de la presenta investigación fue analizar la calidad del sueño entre los policías entendiendo los factores que influyen en su satisfacción con el sueño. Para ello, se utilizó el Índice de Calidad del Sueño de Pittsburgh (PSQI) como herramienta de recolección de datos. La muestra incluyó a un grupo de policías, cuyas respuestas permitieron identificar dos segmentos distintos en cuanto a la calidad del sueño. La metodología consistió en la aplicación del PSQI, un cuestionario ampliamente reconocido y validado para medir diversos aspectos del sueño, tales como la duración, la eficiencia, la latencia y las alteraciones del sueño. Los datos recolectados se segmentaron y analizaron para identificar patrones y diferencias significativas entre los participantes. Los resultados mostraron que existe un segmento de policías con alta satisfacción en la calidad del sueño, caracterizado por no tener dificultades para conciliar el sueño y sentir que su sueño es reparador. En contraste, el segundo segmento presentó problemas significativos para conciliar y mantener el sueño, resultando en una sensación de cansancio constante y dificultades para despertar. Las conclusiones del estudio sugieren la necesidad de implementar intervenciones específicas para mejorar la calidad del sueño entre los policías, especialmente aquellos en el segmento con baja satisfacción. Se recomienda llevar a cabo campañas de autocuidado que incluyan prácticas de ejercicio regular y estrategias de salario emocional, enfocadas en reducir el estrés laboral y mejorar el bienestar general de los policías. Estas medidas no solo mejorarían la calidad del sueño, sino que también contribuirían a un mejor desempeño laboral y a la salud integral de los oficiales

Identificación de un modelo lineal adecuado para evaluar características pre-destete en ganado criollo colombiano Blanco Orejinegro: Identification of an appropriate linear model to evaluate pre-weaning traits in colombian creole cattle Blanco Orejinegro

The Blanco Orejinegro (BON) Creole breed has an adaptation process of more than 500 years to the environmental conditions of Colombia, and it is characterized by being a dual-purpose breed used for both milk and meat production, so it is a very important biological heritage that must be studied. The goal of this study was to identify an appropriate linear model to evaluate pre-weaning traits in BON cattle. Weighing information was collected and filtered from four BON cattle herds. The evaluated traits were weight at 4 months (W4M), weight at weaning (WW) and daily weight gain between 4 months and weaning (DWG4M-W). Nine linear models were evaluated in which were included the following factors as fixed effects: sex, herd, month of weighing or month of birth, calving number, time of weighing or birth (dry and rainy weather), age (covariate, fixed effect and adjusted by regression), year of weaning or year of birth and, contemporary group (CG) formed by sex and herd for DWG4M-W and sex, herd and year of weighing for W4M and WW, with a minimum of five observations in each CG. To identify the most appropriate linear model for each trait, the value of AIC (Akaike information criterion, BIC (Bayesian information criterion), determination coefficient (R2) and sum of squares of error (SCE) were used. The most suitable model for all the traits was the one that involved the contemporary group and age as a fixed effect for W4M and age as a covariate for WW.La Raza criolla Blanco Orejinegro (BON) tiene un proceso de adaptación de más de 500 años a las condiciones ambientales de Colombia. Se caracteriza por ser una raza doble propósito utilizada para la producción de leche y carne, convirtiéndola en un patrimonio biológico de gran importancia que debe ser estudiado. El objetivo de este estudio fue identificar un modelo lineal adecuado para evaluar características pre-destete en ganado criollo Blanco Orejinegro. Se recolectó y depuró información de pesajes de cuatro hatos de ganado BON. Las características evaluadas fueron peso a los 4 meses (P4M), peso al destete (PD) y ganancia diaria de peso entre los 4 meses y el destete (GDP4M-D). Se evaluaron nueve modelos lineales en los que se incluyeron como efectos fijos los siguientes factores: sexo, hato, mes de pesaje o nacimiento, número de parto, época de pesaje o época de nacimiento (época seca o lluviosa), edad (covariable, efecto fijo y ajustada por regresión), año de pesaje o año de nacimiento y grupo contemporáneo (GC) compuesto por sexo y hato para GDP4M-D y sexo, hato y año de pesaje para P4M y PD, con mínimo cinco observaciones por GC. Para identificar el modelo lineal más adecuado para cada característica se utilizó el valor de AIC (Akaike information criterion), BIC (Bayesian information criterion), coeficiente de determinación (R2) y la suma de cuadrados del error (SCE). El modelo más adecuado para todas las características fue aquel que involucró el GC y edad como efecto fijo para P4M y edad como covariable para PD

Identificación de un modelo lineal adecuado para evaluar características pre-destete en ganado criollo colombiano Blanco Orejinegro: Identification of an appropriate linear model to evaluate pre-weaning traits in colombian creole cattle Blanco Orejinegro

The Blanco Orejinegro (BON) Creole breed has an adaptation process of more than 500 years to the environmental conditions of Colombia, and it is characterized by being a dual-purpose breed used for both milk and meat production, so it is a very important biological heritage that must be studied. The goal of this study was to identify an appropriate linear model to evaluate pre-weaning traits in BON cattle. Weighing information was collected and filtered from four BON cattle herds. The evaluated traits were weight at 4 months (W4M), weight at weaning (WW) and daily weight gain between 4 months and weaning (DWG4M-W). Nine linear models were evaluated in which were included the following factors as fixed effects: sex, herd, month of weighing or month of birth, calving number, time of weighing or birth (dry and rainy weather), age (covariate, fixed effect and adjusted by regression), year of weaning or year of birth and, contemporary group (CG) formed by sex and herd for DWG4M-W and sex, herd and year of weighing for W4M and WW, with a minimum of five observations in each CG. To identify the most appropriate linear model for each trait, the value of AIC (Akaike information criterion, BIC (Bayesian information criterion), determination coefficient (R2) and sum of squares of error (SCE) were used. The most suitable model for all the traits was the one that involved the contemporary group and age as a fixed effect for W4M and age as a covariate for WW.La Raza criolla Blanco Orejinegro (BON) tiene un proceso de adaptación de más de 500 años a las condiciones ambientales de Colombia. Se caracteriza por ser una raza doble propósito utilizada para la producción de leche y carne, convirtiéndola en un patrimonio biológico de gran importancia que debe ser estudiado. El objetivo de este estudio fue identificar un modelo lineal adecuado para evaluar características pre-destete en ganado criollo Blanco Orejinegro. Se recolectó y depuró información de pesajes de cuatro hatos de ganado BON. Las características evaluadas fueron peso a los 4 meses (P4M), peso al destete (PD) y ganancia diaria de peso entre los 4 meses y el destete (GDP4M-D). Se evaluaron nueve modelos lineales en los que se incluyeron como efectos fijos los siguientes factores: sexo, hato, mes de pesaje o nacimiento, número de parto, época de pesaje o época de nacimiento (época seca o lluviosa), edad (covariable, efecto fijo y ajustada por regresión), año de pesaje o año de nacimiento y grupo contemporáneo (GC) compuesto por sexo y hato para GDP4M-D y sexo, hato y año de pesaje para P4M y PD, con mínimo cinco observaciones por GC. Para identificar el modelo lineal más adecuado para cada característica se utilizó el valor de AIC (Akaike information criterion), BIC (Bayesian information criterion), coeficiente de determinación (R2) y la suma de cuadrados del error (SCE). El modelo más adecuado para todas las características fue aquel que involucró el GC y edad como efecto fijo para P4M y edad como covariable para PD

Avaliação da aterosclerose subclínica e de níveis plasmáticos de LDL minimamente modificada em pacientes com espondilite anquilosante e sua correlação com a atividade da doença

AbstractIntroductionAccelerated atherosclerosis has been shown in some autoimmune diseases, mainly in Systemic Lupus Erythematosus and Rheumatoid Arthritis. Although high preva- lence of corticosteroids use may be a confounding factor due to their detrimental effects on several risk factors, systemic inflammation per se is supposed to play an important role in atherogenesis in these patients.MethodsWe have evaluated sub-clinical atherosclerosis and plasma levels of circulating electronegative LDL, which represents the fraction of LDL that is minimally modified, in patients with ankylosing spondylitis (AS). Fourteen patients who fulfilled the modified New York criteria for AS were compared with 13 paired controls. Carotid intimal-media thick- ness (IMT) was assessed by ultrasonography bilaterally in common carotid artery, internal carotid artery and in the bifurcation. Groups were homogeneous regarding cardiovascular risk factors. Only a single patient in AS group was in use of corticosteroid.ResultsThe presence of active inflammation was demonstrated by elevated BASDAI and higher CRP levels and in patients versus controls (12.36 vs. 3.45mg/dl, P = 0.002). No dif- ference was found in carotid IMT between both groups, in any site of artery. Averaged IMT (6 measurements, at 3 pre-specified sites bilaterally) was 0.72 ± 0.28 in AS group and 0.70 ± 0.45mm in controls (P = 0.91). Minimally modified LDL did not differ significantly either between patients and controls (14.03 ± 17.40 vs. 13.21 ± 10.21; P = 0.88).ConclusionsPatients with AS did not show increased carotid IMT in comparison to con- trols. In the same way, circulating plasma levels of LDL (-), did not differ significantly in both groups

Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients >= 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were >= 80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29-0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22-0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19

Fitoperifiton asociado al río Acacias-Pajure en la Orinoquia colombiana

Phytoperiphyton refers to the autotrophic component belonging to the periphyton community, composed of aquatic microorganisms that have been monitored for their ecological importance and potential as bioindicators. Few investigations have been carried out on this community in the Colombian Orinoquia, a region with abundant water resources and multiple anthropic pressures, because it is the country’s main agricultural and energy source. Three monitorings were carried out at 12 points along the Acacias-Pajure River, where a total of 41 genera were identified. The highest records of richness were presented at monitoring points 6 and 7, associated with oil palm crops and livestock activity. Navicula (Ochrophyta) and Cosmarium (Charophyta) were the most frequent genera, Oedogonium (Chlorophyta) and Phormidium (Cyanobacteria) the most abundant along the river.El fitoperifiton hace referencia al componente autótrofo perteneciente a la comunidad del perifiton, compuesta por microorganismos acuáticos que han sido monitoreados por su importancia ecológica y potencial como bioindicadores. Son escasos los estudios que se han realizado sobre esta comunidad en la Orinoquia colombiana, región con un abundante recurso hídrico y con múltiples presiones antrópicas, debido a que es la principal despensa agrícola y energética del país. Se realizaron tres monitoreos en 12 puntos a lo largo del río Acacias-Pajure, en donde se identificaron un total de 41 géneros. Los mayores registros de riqueza se presentaron en los puntos de monitoreo 6 y 7, asociados a cultivos de palma de aceite y actividad ganadera. Navicula (Ochrophyta) y Cosmarium (Charophyta) fueron los géneros más frecuentes, Oedogonium (Chlorophyta) y Phormidium (Cyanobacteria) los más abundantes a lo largo del río

Impact of operatoŕs experience on peri-procedural outcomes with Watchman FLX: Insights from the FLX-SPA registry

Background: The Watchman FLX is a device upgrade of the Watchman 2.5 that incorporates several design enhancements intended to simplify left atrial appendage occlusion (LAAO) and improve procedural outcomes. This study compares peri-procedural results of LAAO with Watchman FLX (Boston Scientific, Marlborough, Massachusetts) in centers with varying degrees of experience with the Watchman 2.5 and Watchman FLX. Methods: Prospective, multicenter, 'real-world' registry including consecutive patients undergoing LAAO with the Watchman FLX at 26 Spanish sites (FLX-SPA registry). Implanting centers were classified according to the center's prior experience with the Watchman 2.5. A further division of centers according to whether or not they had performed ≤ 10 or > 10Watchman FLX implants was prespecified at the beginning of the study. Procedural outcomes of institutions stratified according to their experience with the Watchman 2.5 and FLX devices were compared. Results: 359 patients [mean age 75.5 (SD8.1), CHA2DS2-VASc 4.4 (SD1.4), HAS-BLED 3.8(SD0.9)] were included. Global success rate was 98.6%, successful LAAO with the first selected device size was achieved in 95.5% patients and the device was implanted at first attempt in 78.6% cases. There were only 9(2.5%) major peri-procedural complications. No differences in efficacy or safety results according to the centeŕs previous experience with Watchman 2.5 and procedural volume with Watchman FLX existed. Conclusions: The Watchman FLX attains high procedural success rates with complete LAA sealing in unselected, real-world patients, along with a low incidence of peri-procedural complications, regardless of operatoŕs experience with its previous device iteration or the number of Watchman FLX devices implanted

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk outcome pairs, and new data on risk exposure levels and risk outcome associations. Methods: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings: In 2017,34.1 million (95% uncertainty interval [UI] 33.3-35.0) deaths and 121 billion (144-1.28) DALYs were attributable to GBD risk factors. Globally, 61.0% (59.6-62.4) of deaths and 48.3% (46.3-50.2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10.4 million (9.39-11.5) deaths and 218 million (198-237) DALYs, followed by smoking (7.10 million [6.83-7.37] deaths and 182 million [173-193] DALYs), high fasting plasma glucose (6.53 million [5.23-8.23] deaths and 171 million [144-201] DALYs), high body-mass index (BMI; 4.72 million [2.99-6.70] deaths and 148 million [98.6-202] DALYs), and short gestation for birthweight (1.43 million [1.36-1.51] deaths and 139 million [131-147] DALYs). In total, risk-attributable DALYs declined by 4.9% (3.3-6.5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23.5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18.6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning