An Investigation into the Economic Thought of Medieval Arab-Islamic Scholars and Enlightenment Philosophers

This student-faculty collaborative research project focused on the contributions to economic thought of two distinct groups: medieval Arab-Islamic scholars and Enlightenment philosophers. The primary goal of the project was to generate two new chapters to supplement the Evolution of Economic Thought text. It looked to answer the research question, “How did the intellectual activity of medieval Arab-Islamic scholars and Enlightenment philosophers reflect and/or contribute to the development of modern economic thought?” The medieval Arab-Islamic chapter produced findings including a centrality of religion to economic life, the importance of specialization for increased efficiency, and an understanding of just price. Ibn Khaldūn, a prominent scholar of the medieval Arab-Islamic era, recognized a need for the division of labor, as individuals lack the capability of providing sufficient goods on their own to subsist. A holistic approach to thinking and an emphasis on rational methodology and objectivity were major contributions from the research on Enlightenment philosophers. Thomas Hobbes’s social contract theory is a philosophical idea that underlies modern economic theory, discussed at length in the Enlightenment chapter. Both chapters will be accessible online and available for instructors to use separately or in conjunction with existing online chapters as precursors to the main, physical text

Effects of structural confinement and thermal profiles on propagating spin waves, The

2018 Spring.Includes bibliographical references.Spintronics is a growing field that relies on the spin degree of freedom in the form of spin currents instead of electronic charge to transmit and process information. There are many advantages to spin-based devices including scalability, a wide range of host materials including insulators, and almost no energy loss due to Joule heating. Spin angular momentum can be transmitted in the form of spin-polarized currents that flow through a metal, pure spin currents, or in the form of spin waves, disturbances in the magnetization state that can propagate and hence can carry energy. If such a spin-based paradigm is to be realized, there are many open questions that must be addressed. Two questions of particular importance are: how can short wavelength spin waves that are needed for information transmission be controllably generated? and once generated, how can these spin waves be modified and controlled? This thesis focusses on answering both of these questions through the investigation of spin waves in two different types of samples, patterned microstructures and thin continuous films, performed using Brillouin light scattering (BLS) spectroscopy. In the first experiment, the possibility of generating short wavelength spin waves by dynamically exciting a non-uniform magnetic state called the antivortex (AV) in a Permalloy microstructure is explored. Frequency scans were performed to identify a spectrum of high-frequency modes of the AV state. These modes were then individually mapped out by pumping at the frequency of the mode and performing spatially-resolved BLS scans. Comparing the experimental results with dispersion curves and micromagnetic simulations reveals that some of most prominent modes involve coupling of the AV dynamics to propagating spin waves in the adjacent nanowires highlighting the fact that the local magnetization state has a significant effect on the spin wave dynamics. Due to the natural way that an antivortex state can be incorporated into a nanowire network, this spin configuration may be useful as a means to generate or control spin waves for applications. In the second study we explore the possibility of modifying the propagation characteristics of both spin waves and spin caustic beams, which could be highly useful in spin-wave-based logic devices, using non-uniform thermal gradients up to 4.5 K/mm. These experiments were performed in a yttrium iron garnet (YIG) thin film - a model system for studying spin waves due to extremely low damping characteristics. An intricate diamond-shaped propagation pattern was observed and explained using the dispersion manifold for the YIG film and considering the range of wavevectors excited by the antenna. Significant modifications to the propagation characteristics such as beam angle, temporal pulse shape, mode profiles, and group velocity were observed as spin waves travelled into heated regions. These results will serve to broaden the understanding of how heat can be used to affect and control spin waves

Vegetative and Climatic Controls on Holocene Wildfire and Erosion Recorded in Alluvial Fans of the Middle Fork Salmon River, Idaho

The Middle Fork Salmon River watershed spans high-elevation mixed-conifer forests to lower-elevation shrub-steppe. In recent decades, runoff from severely burned hillslopes has generated large debris flows in steep tributary drainages. These flows incised alluvial fans along the mainstem river, where charcoal-rich debris-flow and sheetflood deposits preserve a record of latest Pleistocene to Holocene fires and geomorphic response. Through deposit sedimentology and 14C dating of charcoal, we evaluate the processes and timing of fire-related sedimentation and the role of climate and vegetation change. Fire-related deposits compose ~66% of the total measured fan deposit thickness in more densely forested upper basins versus ~33% in shrub-steppe-dominated lower basins. Fires during the middle Holocene (~8000 - 5000 cal yr BP) mostly resulted in sheetflood deposition, similar to modern events in lower basins. Decreased vegetation density during this generally warmer and drier period likely resulted in lower-severity fires and more frequent but smaller fire-related sedimentation events. In contrast, thick fire-related debris-flow deposits of latest Pleistocene-early Holocene (~13,500-8000 cal yr BP) and late Holocene (\u3c 4000 cal yr BP) age are inferred to represent higher-severity fires, though data in the former period are limited. Widespread fires occurred in both upper and lower basins within the Medieval Climatic Anomaly (1050-650 cal yr BP) and the early Little Ice Age ca. 550 cal yr BP. We conclude that a generally cooler late Holocene climate and a shift to denser lodgepole pine forests in upper basins by ~2500 cal yr BP provided fuel for severe fires during episodic droughts

Multiple Paths Forward: Diversifying Mathematics as a Strategy for College Success (Executive Summary)

This executive summary outlines key findings from a report on how colleges are creating math pathways that are aligned with students' programs of study

The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes.

RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be tightly regulated by nucleotide exchange or hydrolysis. Instead, there is a growing understanding that the protein abundance of RIT1 is important for its regulation and function. We previously identified the deubiquitinase USP9X as a RIT1 dependency in RIT1-mutant cells. Here, we demonstrate that both wild-type and mutant forms of RIT1 are substrates of USP9X. Depletion of USP9X leads to decreased RIT1 protein stability and abundance and resensitizes cells to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in vitro and in vivo. Our work expands upon the current understanding of RIT1 protein regulation and presents USP9X as a key regulator of RIT1-driven oncogenic phenotypes

ENSO-driven extreme oscillations in mean sea level destabilise critical shoreline mangroves—An emerging threat

Recent ENSO-related, extreme low oscillations in mean sea level, referred to as ‘Taimasa’ in Samoa, have destabilised shoreline mangroves of tropical northern Australia, and possibly elsewhere. In 1982 and 2015, two catastrophic Taimasa each resulted in widespread mass dieback of ~76 km2 of shoreline mangroves along 2,000 km of Australia’s Gulf of Carpentaria. For the 2015 event, we determined that a temporary drop in sea level of ~0.4 metres for up to six months duration caused upper zone shoreline mangroves across the region to die from severe moisture deficit and desiccation. The two dramatic collapse events revealed a previously unrecognised vulnerability of semi-arid tidal wetland habitats to more extreme ENSO influences on sea level. In addition, we also observed a relationship between annual sea level oscillations and mangrove forest productivity where seasonal oscillations in mean sea level were co-incident with regular annual mangrove leaf growth during months of higher sea levels (March-May), and leaf shedding during lower sea levels (September-November). The combination of these periodic fluctuations in sea level defined a mangrove ‘Goldilocks’ zone of seasonal productivity during median-scale oscillations, bracketed by critical threshold events when sea levels became unusually low, or high. On the two occasions reported here when sea levels were extremely low, upper zone mangrove vegetation died en masse in synchrony across northern Australia. Such extreme pulse impacts combined with localised stressors profoundly threaten the longer-term survival of mangrove ecosystems and their benefits, like minimisation of shoreline erosion with rising sea levels. These new insights into such critical influences of climate and sea level on mangrove forests offer further affirmation of the urgency for implementing well-considered mitigation efforts for the protection of shoreline mangroves at risk, especially given predictions of future re-occurrences of extreme events affecting sea levels, combined with on-going pressure of rapidly rising sea levels

Identifying methamphetamine use predictors in HIV infection: Immune-dopaminergic signatures in peripheral leukocytes and the role of COMT genotype

The pursuit of translational biomarkers is complex due to the heterogeneous human pathophysiology, but critical for disease diagnosis, prognosis, monitoring therapeutic efficacy, and for patient stratification. In HIV-associated neurocognitive impairment (NCI), biomarkers that delineate the trajectory of neuropathogenesis and neurocognitive sequelae are critical, particularly considering confounders such as substance use, including Methamphetamine (METH). METH use is a significant health concern among persons living with HIV (PWH), aggravating cognitive deficits and neuroinflammation despite of antiretrovirals, introducing elements in the microenvironment that are fundamentally differerent in relation to non-METH users, such as high levels of dopamine (DA) affecting HIV-innate immune targets. Yet, current biomarkers do not detect these differences. We hypothesized that predefined DA-induced signatures detectable in peripheral blood leukocytes, can distinguish HIV+ METH users compared to HIV-negative or PWH that are non METH users. The elevated expression of CD8A, CREBBP, CCL5, and combinations of dopaminergic pathway transcripts clustered METH users with detectable CSF viral load and major depressive disorder (MDD), indicating neuroimmune-mechanistic links. Cathecol-o-methyltransferase (COMT) gene polymorphisms affecting DA metabolism improved the identification of PWH using METH with biomarkers. The results indicate that underlying immunedopaminergic mechanisms provide signatures and genotypes that can identify PWH that are METH users and their attributes