Setting up an acupuncture knee clinic under Practice Based Commissioning

Original article can be found at: http://www.acupunctureinmedicine.org.uk/index.shtmlThis paper outlines the setting up of a new service in primary care offering acupuncture to patients with severe osteoarthritis of the knee. The high volume clinic is funded under the Practice Based Commissioning initiative and is the first of its type in the UK. It would appear to offer a model for similar services elsewhere.Peer reviewe

Hierarchical models of very large problems, dilemmas, prospects, and an agenda for the future

Interdisciplinary approaches to the modeling of global problems are discussed in terms of multilevel cooperation. A multilevel regionalized model of the Lake Erie Basin is analyzed along with a multilevel regionalized world modeling project. Other topics discussed include: a stratified model of interacting region in a world system, and the application of the model to the world food crisis in south Asia. Recommended research for future development of integrated models is included

Multispectral processing based on groups of resolution elements

Several nine-point rules are defined and compared with previously studied rules. One of the rules performed well in boundary areas, but with reduced efficiency in field interiors; another combined best performance on field interiors with good sensitivity to boundary detail. The basic threshold gradient and some modifications were investigated as a means of boundary point detection. The hypothesis testing methods of closed-boundary formation were also tested and evaluated. An analysis of the boundary detection problem was initiated, employing statistical signal detection and parameter estimation techniques to analyze various formulations of the problem. These formulations permit the atmospheric and sensor system effects on the data to be thoroughly analyzed. Various boundary features and necessary assumptions can also be investigated in this manner

Coboson formalism for Cooper pairs used to derive Richardson's equations

We propose a many-body formalism for Cooper pairs which has similarities to the one we recently developed for composite boson excitons (coboson in short). Its Shiva diagram representation evidences that $N$ Cooper pairs differ from $N$ single pairs through electron exchange only: no direct coupling exists due to the very peculiar form of the BCS potential. As a first application, we here use this formalism to derive Richardson's equations for the exact eigenstates of $N$ Cooper pairs. This gives hints on why the $N(N-1)$ dependence of the $N$-pair ground state energy we recently obtained by solving Richardson's equations analytically in the low density limit, stays valid up to the dense regime, no higher order dependence exists even under large overlap, a surprising result hard to accept at first. We also briefly question the BCS wave function ansatz compared to Richardson's exact form, in the light of our understanding of coboson many-body effects

Substrate Induced Denitrification over or under Estimates Shifts in Soil N2/N2O Ratios

Funding: Funding was provided by the Biotechnology and Biological Sciences Research Council, BBSRC UK (http://www.bbsrc.ac.uk). Grant number BB/H013431/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

A fast and robust numerical scheme for solving models of charge carrier transport and ion vacancy motion in perovskite solar cells

Drift-diffusion models that account for the motion of both electronic and ionic charges are important tools for explaining the hysteretic behaviour and guiding the development of metal halide perovskite solar cells. Furnishing numerical solutions to such models for realistic operating conditions is challenging owing to the extreme values of some of the parameters. In particular, those characterising (i) the short Debye lengths (giving rise to rapid changes in the solutions across narrow layers), (ii) the relatively large potential differences across devices and (iii) the disparity in timescales between the motion of the electronic and ionic species give rise to significant stiffness. We present a finite difference scheme with an adaptive time step that is posed on a non-uniform staggered grid that provides second order accuracy in the mesh spacing. The method is able to cope with the stiffness of the system for realistic parameters values whilst providing high accuracy and maintaining modest computational costs. For example, a transient sweep of a current-voltage curve can be computed in only a few minutes on a standard desktop computer.Comment: 22 pages, 8 figure

Economic Benefits of American Lobster Fishery Management Regulations

A simulation model is used to compare measures for future management identified in the American lobster fishery management plan; specifically, increases in the minimum legal size and a modest reduction in aggregate fishing mortality are evaluated. The analysis differs from previous work in that the distributional aspects of the alternative management regulations are quantified. The results indicate that (1) both an increased minimum size and a reduction in fishing mortality are economically justified in the sense that net benefits are positive; (2) increasing the minimum size without an adjunct regulation to prohibit entry will cause present fishermen to suffer an initial short-term reduction in revenues for which there will be no long-term gain; (3) because increased minimum size can be justified on the basis of consumer benefits alone, arguments favoring its increase to prevent recruitment failure are moot as far as a test of national economic efficiency is concerned; and (4) a program of effort reduction which reduces by 20% the fraction of available lobsters captured annually is projected to generate SI of producer benefits for every pound of lobster landed. Reducing the annual harvest fraction by 20% results in a level of fishery benefits greater than increasing the minimum size to 89 mm (3^-in.), and increases the coincidence of short-run costs and long-term benefits among those impacted by fishery management.Environmental Economics and Policy, Resource /Energy Economics and Policy,

Novel Fiber Design for Wideband Conversion and Amplification in Multimode Fibers

We propose an operating principle to achieve broadband and highly tunable mode conversion and amplification exploiting inter-modal four wave mixing in a multimode fiber. A bandwidth of 30 nanometers is demonstrated by properly designing a simple step-index silica fiber.Comment: Ecoc conference 201

Crystallization of a Mos1 transposase-inverted-repeat DNA complex: biochemical and preliminary crystallographic analyses

A complex formed between Mos1 transposase and its inverted-repeat DNA has been crystallized. The crystals diffract to 3.25 Å resolution and exhibit monoclinic (P2(1)) symmetry, with unit-cell parameters a = 120.8, b = 85.1, c = 131.6 Å, β = 99.3°. The X-ray diffraction data display noncrystallographic twofold symmetry and characteristic dsDNA diffraction at ∼3.3 Å. Biochemical analyses confirmed the presence of DNA and full-length protein in the crystals. The relationship between the axis of noncrystallographic symmetry, the unit-cell axes and the DNA diffraction pattern are discussed. The data are consistent with the previously proposed model of the paired-ends complex containing a dimer of the transposase

Reaction Diffusion and Ballistic Annihilation Near an Impenetrable Boundary

The behavior of the single-species reaction process $A+A\to O$ is examined near an impenetrable boundary, representing the flask containing the reactants. Two types of dynamics are considered for the reactants: diffusive and ballistic propagation. It is shown that the effect of the boundary is quite different in both cases: diffusion-reaction leads to a density excess, whereas ballistic annihilation exhibits a density deficit, and in both cases the effect is not localized at the boundary but penetrates into the system. The field-theoretic renormalization group is used to obtain the universal properties of the density excess in two dimensions and below for the reaction-diffusion system. In one dimension the excess decays with the same exponent as the bulk and is found by an exact solution. In two dimensions the excess is marginally less relevant than the bulk decay and the density profile is again found exactly for late times from the RG-improved field theory. The results obtained for the diffusive case are relevant for Mg$^{2+}$ or Cd$^{2+}$ doping in the TMMC crystal's exciton coalescence process and also imply a surprising result for the dynamic magnetization in the critical one-dimensional Ising model with a fixed spin. For the case of ballistic reactants, a model is introduced and solved exactly in one dimension. The density-deficit profile is obtained, as is the density of left and right moving reactants near the impenetrable boundary.Comment: to appear in J. Phys.