Towards a DUNE photon detection system

The Deep Underground Neutrino Experiment (DUNE) will be sensitive to neutrino interactions in it liquid argon detector volume. Its primary objective is to measure mixing parameters relevant to neutrino oscillations. Another aspect of the primary science program is to measure neutrinos produced in core-collapse supernovae should one occur in the Milky Way Galaxy while the far detector is operational. The first 10kt module of DUNE will be a single phase Liquid Argon Time Projection Chamber (LarTPC). The goal of measuring neutrinos from supernovae requires an advanced photon detection system. Its design is driven by lessons from protoDUNE where testing of photon sensor components has been ongoing since at least 2016. It is also driven by simulations of supernova neutrino interactions

Situation of HIV infections and STIs in the United Kingdom in 2007.

In the United Kingdom (UK) in 2007, an estimated 77,400 persons were living with human immunodeficiency virus (HIV) of whom 28% are unaware of their infection. A total of 7,734 persons were newly diagnosed with HIV infection in 2007, of which 31% were diagnosed late. This highlights the need for wider HIV testing, especially in those areas with a high diagnosed prevalence, as recommended in recent national guidelines. Among newly diagnosed cases of HIV in 2007, 41% acquired their infection through sex between men (four in five of whom acquired their infection in the UK) and 55% through heterosexual contact (four in five of whom acquired their infection abroad, mainly in sub-Saharan Africa). Young persons aged 16 to 24 years are disproportionally affected by sexually transmitted diseases (STIs) accounting for 65% of genital chlamydia infections, 50% of cases of genital warts and 50% of cases of gonorrhoea that were diagnosed in 2007

Limit Distributions of Self-Normalized Sums

If Xi are i.i.d. and have zero mean and arbitrary finite variance the limiting probability distribution of Sn(2) =(∑ni=1 Xi)/(∑nj=1Xj2)1/2 as n→∞ has density f(t) = (2π)−1/2 exp(−t2/2) by the central limit theorem and the law of large numbers. If the tails of Xi are sufficiently smooth and satisfy P(Xi \u3e t) ∼ rt−α and P(Xi \u3c −t) ∼ lt−α as t→∞, where 0 \u3c α \u3c 2, r \u3e 0, l \u3e 0, Sn(2) still has a limiting distribution F even though Xi has infinite variance. The density f of F depends on α as well as on r/l. We also study the limiting distribution of the more general Sn(p) = (∑ni=1Xi)/(∑nj=1 |Xj|p)1/p where Xi are i.i.d. and in the domain of a stable law G with tails as above. In the cases p = 2 (see (4.21)) and p = 1 (see (3.7)) we obtain exact, computable formulas for f(t) = f(t,α,r/l), and give graphs of f for a number of values of α and r/l. For p = 2, we find that f is always symmetric about zero on (−1,1), even though f is symmetric on (−∞,∞) only when r = l

Absence of hysteresis at the Mott-Hubbard metal-insulator transition in infinite dimensions

The nature of the Mott-Hubbard metal-insulator transition in the infinite-dimensional Hubbard model is investigated by Quantum Monte Carlo simulations down to temperature T=W/140 (W=bandwidth). Calculating with significantly higher precision than in previous work, we show that the hysteresis below T_{IPT}\simeq 0.022W, reported in earlier studies, disappears. Hence the transition is found to be continuous rather than discontinuous down to at least T=0.325T_{IPT}. We also study the changes in the density of states across the transition, which illustrate that the Fermi liquid breaks down before the gap opens.Comment: 4 pages, 4 eps-figures using epsf.st

High-Quality Draft Genome Sequence of Pseudomonas aeruginosa 268 Isolated from a Patient with a Left Ventricular Assist Device.

Pseudomonas aeruginosa is known to cause persistent bloodstream infections associated with left ventricular assist devices (LVAD). Here, we present the high-quality draft genome assembly for a clinical isolate, P. aeruginosa 268. The genome sequence is available in GenBank under accession number CP032761

A novel piggyback strategy for mRNA delivery exploiting adenovirus entry biology

Molecular therapies exploiting mRNA vectors embody enormous potential, as evidenced by the utility of this technology for the context of the COVID-19 pandemic. Nonetheless, broad implementation of these promising strategies has been restricted by the limited repertoires of delivery vehicles capable of mRNA transport. On this basis, we explored a strategy based on exploiting the well characterized entry biology of adenovirus. To this end, we studied an adenovirus-polylysine (AdpL) that embodied piggyback transport of the mRNA on the capsid exterior of adenovirus. We hypothesized that the efficient steps of Ad binding, receptor-mediated entry, and capsid-mediated endosome escape could provide an effective pathway for transport of mRNA to the cellular cytosol for transgene expression. Our studies confirmed that AdpL could mediate effective gene transfer of mRNA vectors in vitro and in vivo. Facets of this method may offer key utilities to actualize the promise of mRNA-based therapeutics

The low-energy scale of the periodic Anderson model

Wilson's Numerical Renormalization Group method is used to study the paramagnetic ground state of the periodic Anderson model within the dynamical mean-field approach. For the particle-hole symmetric model, which is a Kondo insulator, we find that the lattice Kondo scale T_0 is strongly enhanced over the impurity scale T_K; T_0/T_K ~ exp(1/3I), where I is the Schrieffer-Wolff exchange coupling. In the metallic regime, where the conduction band filling is reduced from one, we find characteristic signatures of Nozi\`eres exhaustion scenario, including a strongly reduced lattice Kondo scale, a significant suppression of the states available to screen the f-electron moment, and a Kondo resonance with a strongly enhanced height. However, in contrast to the quantitative predictions of Nozi\`eres, we find that the T_0 ~ T_K with a coefficient which depends strongly on conduction band filling.Comment: 11 pages, 9 figures, submitted to Phys. Rev.

Correlation ECE diagnostic in Alcator C-Mod

Correlation ECE (CECE) is a diagnostic technique that allows measurement of small amplitude electron temperature, T[subscript e], fluctuations through standard cross-correlation analysis methods. In Alcator C-Mod, a new CECE diagnostic has been installed[Sung RSI 2012], and interesting phenomena have been observed in various plasma conditions. We find that local T[subscript e] fluctuations near the edge (ρ ~ 0:8) decrease across the linearto- saturated ohmic confinement transition, with fluctuations decreasing with increasing plasma density[Sung NF 2013], which occurs simultaneously with rotation reversals[Rice NF 2011]. T[subscript e] fluctuations are also reduced across core rotation reversals with an increase of plasma density in RF heated L-mode plasmas, which implies that the same physics related to the reduction of T[subscript e] fluctuations may be applied to both ohmic and RF heated L-mode plasmas. In I-mode plasmas, we observe the reduction of core T[subscript e] fluctuations, which indicates changes of turbulence occur not only in the pedestal region but also in the core across the L/I transition[White NF 2014]. The present CECE diagnostic system in C-Mod and these experimental results are described in this paper

Frictional behavior of oceanic transform faults and its influence on earthquake characteristics

Author Posting. © American Geophysical Union, 2012. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 117 (2012): B04315, doi:10.1029/2011JB009025.We use a three-dimensional strike-slip fault model in the framework of rate and state-dependent friction to investigate earthquake behavior and scaling relations on oceanic transform faults (OTFs). Gabbro friction data under hydrothermal conditions are mapped onto OTFs using temperatures from (1) a half-space cooling model, and (2) a thermal model that incorporates a visco-plastic rheology, non-Newtonian viscous flow and the effects of shear heating and hydrothermal circulation. Without introducing small-scale frictional heterogeneities on the fault, our model predicts that an OTF segment can transition between seismic and aseismic slip over many earthquake cycles, consistent with the multimode hypothesis for OTF ruptures. The average seismic coupling coefficient χ is strongly dependent on the ratio of seismogenic zone width W to earthquake nucleation size h*; χ increases by four orders of magnitude as W/h* increases from ∼1 to 2. Specifically, the average χ = 0.15 ± 0.05 derived from global OTF earthquake catalogs can be reached at W/h* ≈ 1.2–1.7. Further, in all simulations the area of the largest earthquake rupture is less than the total seismogenic area and we predict a deficiency of large earthquakes on long transforms, which is also consistent with observations. To match these observations over this narrow range of W/h* requires an increase in the characteristic slip distance dc as the seismogenic zone becomes wider and normal stress is higher on long transforms. Earthquake magnitude and distribution on the Gofar and Romanche transforms are better predicted by simulations using the visco-plastic model than the half-space cooling model.This work was supported by NSF-EAR award 1015221, NSF-OCE award 1061203, and a J. Lamar Worzel Assistant Scientist Fund to Y. Liu at WHOI.2012-10-2