4 research outputs found

    The Relationships of SNS Use, Social Achievement Goals, and Life Satisfaction: A Study of Korean College Students

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    Social networking sites (SNS) provide efficient communication. However, SNS use sometimes risks a user’s life satisfaction. Based on the prior findings that one’s social orientation influences the impact of SNS use on life satisfaction, this study examined the pathways to explain how SNS use affects individuals’ life satisfaction through social achievement goals. A main path model and two gender-specified path models were tested using 438 Korean college student samples. The results showed that social development goals mediated the relationships between active SNS use and life satisfaction across all three path models. The social demonstration approach goal was positively predicted by active SNS use in the main model and the male model, but it did not predict life satisfaction in both models. The social demonstration-avoidance goal was positively predicted by active SNS use in the main and female models. Still, it negatively predicted life satisfaction in both models. Implications and directions for future study are discussed

    TIMSS 2015 Korean Student, Teacher, and School Predictor Exploration and Identification via Random Forests

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    Previous TIMSS studies have employed conventional statistical methods, focusing on selected few indicators. The purpose of this study was to explore and identify important variables to predict students mathematics achievement, utilizing as many student, teacher, and school variables as possible via random forests, a popular machine learning technique. TIMSS 2015 Korean 8th graders student, teacher, and school datasets were merged to extract important predictors for students mathematics achievement. The prediction accuracy, sensitivity, and specificity of the model were 78%, 83%, and 73%, respectively. Among 413 TIMSS variables explored, variables identified as having the highest variable importance were all student variables, consistent with previous research. Scientific importance of the study was discussed as well as further research topics.This work was supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea (NRF-2015S1A2A1A01025538)

    Stem Cell Factor SOX9 Interacts with a Cell Death Regulator RIPK1 and Results in Escape of Cancer Stem Cell Death

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    High-grade ovarian cancer (HGOC) is the most lethal gynecological cancer, with high metastasis and recurrence. Cancer stem cells (CSCs) are responsible for its apoptosis resistance, cancer metastasis, and recurrence. Thus, targeting CSCs would be a promising strategy for overcoming chemotherapy resistance and improving patient prognosis in HGOC. Among upregulated oncogenic proteins in HGOC, we found that transcription factor SOX9 showed a strong correlation with stemness-regulating ALDH1A1 and was localized predominantly in the cytoplasm of HGOC with lymph node metastasis. In order to address the role of unusual cytoplasmic SOX9 and to explore its underlying mechanism in HGOC malignancy, a Y2H assay was used to identify a necroptotic cell death-associated cytoplasmic protein, receptor-interacting serine/threonine protein kinase 1 (RIPK1), as a novel SOX9-interacting partner and further mapped their respective interacting domains. The C-terminal region containing the transactivation domain of SOX9 interacted with the death domain of R1PK1. Consistent with its stemness-promoting function, SOX9 knockdown in vitro resulted in changes in cell morphology, cell cycle, stem cell marker expression, cell invasion, and sphere formation. Furthermore, in vivo knockdown completely inhibited tumor growth in mouse xenograft model. We propose that cytoplasmic SOX9-mediated cell death suppression would contribute to cancer stem cell survival in HGOC

    Acceptable donor-specific antibody levels before and after desensitization therapy in living donor kidney transplantation

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    Background: Plasmapheresis (PP) is commonly used for desensitization in highly sensitized patients with donor-specific antibodies (DSA) in living donor kidney transplantation. We analyzed the impact of DSA levels before and after desensitization on renal allograft outcome. Methods: Twenty-three patients who underwent desensitization with PP, intravenous immunoglobulin (WIG), and rituximab before kidney transplantation in Seoul National University Hospital from August 2006 to August 2016 were enrolled. The association of median fluorescent intensity (MFI) value of DSA with graft outcome was analyzed. Results: The frequency of positive HLA class II DSA after desensitization was lower in patients without antibody-mediated rejection (AMR) compared to those with AMR (p = 0.006). The cutoff value of MFI sum of HLA class II DSA after desensitization for predicting AMR was 2,122 with 63% sensitivity and 94% specificity. The frequency of moderate HLA class II DSA (MFI 5,000 - 10,000) after desensitization was significantly higher in patients with graft loss compared to those without graft loss (p = 0.02). Conclusions: Weak HLA class II DSA after desensitization including PP, WIG, and rituximab was related to AMR and moderate levels of HLA class II DSA after desensitization was related to graft loss in living donor kidney transplantation.N
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