22 research outputs found
Figure S1 from Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in <i>Streptococcus pneumoniae</i>
Absorption spectrum of Spr1654 and Spr1654-PLP. (a) Analysis of recombinant Spr1654-his (MW 47.7 kDa) by SDS-gel electrophoresis. The protein was separated by SDS-12% PAGE, followed by staining with Coomassie blue. Lane 1, Spr1654-his; M, molecular mass marker. (b) The absorption spectra of Spr1654 with (red line) and without PLP (blue line) were collected between 300 and 500 nm. The appearance of a 420nm peak indicates PLP binding to Spr1654
Figure S2 from Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in <i>Streptococcus pneumoniae</i>
Residue Tyr84 in Spr1654 allows enough space for accommodating the N-acetyl group of the sugar substrate. Residues Y84 in Spr1654, W89 in ArnB and F84 in PseC are colored in cyan, orange and violet, respectively. PseC binds to PMP-UDP-4-amino-4, 6-dideoxy-L-AltNAc (PMP-UDP-L-AltNAc) and ArnB binds to UDP- 4-amino-4-deoxy-L-Arabinose (UDP- Ara4N)
Additional file 1: Table S1. of Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study
Characteristics of the patients with and without AGI. (DOC 54 kb
Additional file 2: Table S2. of Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study
AGI grading during the 7-day ICU stay among survivors and nonsurvivors. (DOC 61 kb
Epidemiology and Outcome of Severe Sepsis and Septic Shock in Intensive Care Units in Mainland China
<div><p>Introduction</p><p>Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology and outcome of severe sepsis and septic shock in mixed ICU in mainland China, as well as the independent predictors of mortality.</p><p>Methods</p><p>We performed a 2-month prospective, observational cohort study in 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during the study period were screened and patients with severe sepsis or septic shock were included.</p><p>Results</p><p>A total of 484 patients, 37.3 per 100 ICU admissions were diagnosed with severe sepsis (n = 365) or septic shock (n = 119) according to clinical criteria and included into this study. The most frequent sites of infection were the lung and abdomen. The overall ICU and hospital mortality rates were 28.7% (n = 139) and 33.5% (n = 162), respectively. In multivariate analyses, APACHE II score (odds ratio[OR], 1.068; 95% confidential interval[CI], 1.027–1.109), presence of ARDS (OR, 2.676; 95%CI, 1.691–4.235), bloodstream infection (OR, 2.520; 95%CI, 1.142–5.564) and comorbidity of cancer (OR, 2.246; 95%CI, 1.141–4.420) were significantly associated with mortality.</p><p>Conclusions</p><p>Our results indicated that severe sepsis and septic shock were common complications in ICU patients and with high mortality in China, and can be of help to know more about severe sepsis and septic shock in China and to improve characterization and risk stratification in these patients.</p></div
Distribution of microorganisms isolated from 148 patients.
<p>*including Burkholderia cepacia, Chryseobacter iumindologenes, Enterobacter cloacae, Enterobacteraerogenes, and Serratialiquefaciens.</p><p>**fungal infection here refers to the invasive fungal infection and fungemia.</p><p>Distribution of microorganisms isolated from 148 patients.</p
Flow diagram of enrolled patients and their outcome.
<p>ICU, intensive care unit; LOS, length of stay.</p
Multivariate logistic regression analysis of independent predictors of hospital mortality in patients with severe sepsis and septic shock.
<p>APACHE II, Acute Physiology and Chronic Health Evaluation II; ARDS, Acute respiratory distress syndrome; CI, confidence interval; OR, odds ratio.</p><p>Multivariate logistic regression analysis of independent predictors of hospital mortality in patients with severe sepsis and septic shock.</p
Characteristics of participating ICUs.
<p>ICU, intensive care unit; IQR, interquartile range.</p><p>Characteristics of participating ICUs.</p
The source of infection of patients with severe sepsis (total >100% because 167 patients had more than one infection sites).
<p>The source of infection of patients with severe sepsis (total >100% because 167 patients had more than one infection sites).</p