Il Fenomeno delle Dipendenze nel territorio della ASL MI 1. Dati anno 2009

Report on the state of legal and illegal substances use in the territory of the Local Healthcare Service-MI 1, Province of Milan.Il Report analizza il fenomeno delle dipendenze nella ASL Milano 1. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1-uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale); 2-prevalenza d\u27uso problematico delle sostanze psicoattive; 3-domanda di trattamento degli utilizzatori di sostanze; 4-mortalit? degli utilizzatori di sostanze; 5-malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

Osservatorio territoriale droga e tossicodipendenze. Il Fenomeno delle dipendenze sul territorio della ASL MI 1. Anno 2006

Report on the state of legal and illegal substances use in the territory of the Local Healthcare Service-MI 1, Province of MilanIl Report analizza il fenomeno delle dipendenze nel territorio della ASL MI1 provincia di Milano. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1-uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale); 2-prevalenza d\u27uso problematico delle sostanze psicoattive; 3-domanda di trattamento degli utilizzatori di sostanze; 4-mortalit? degli utilizzatori di sostanze; 5-malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

Osservatorio territoriale droga e tossicodipendenze. Il Fenomeno delle dipendenze sul territorio della ASL MI 1. Anno 2007.

Report on the state of legal and illegal substances use in the territory of the Local Healthcare Service-Mi 2, Province of Milan.Il report analizza il fenomeno delle dipendenze nel territorio della ASL Milano 2. La descrizione del fenomeno si sviluppa intorno all\u27analisi degli indicatori individuati dall\u27Osservatorio Europeo delle Dipendenze di Lisbona (OEDT): 1) uso di sostanze nella popolazione generale (questo indicatore va a rilevare i comportamenti nei confronti di alcol e sostanze psicoattive da parte della popolazione generale; 2) prevalenza d\u27uso problematico delle sostanze psicoattive; 3) domanda di trattamento degli utilizzatori di sostanze; 4) mortalit? degli utilizzatori di sostanze; 5) malattie infettive. Altri due importanti indicatori che si stanno sviluppando, e che vengono qui illustrati, sono l\u27analisi delle Schede di Dimissione Ospedaliera (SDO) e gli indicatori relativi alle conseguenza sociali dell\u27uso di droghe (criminalit? droga correlata). Inoltre sono state applicate diverse metodologie standard di stima sia per quantificare la quota parte sconosciuta di utilizzatori di sostanze che non afferiscono ai servizi, sia per identificarne alcune caratteristiche

Combined expression of JHDM1D/KDM7A gene and long non-coding RNA RP11-363E7.4 as a biomarker for urothelial cancer prognosis

Abstract Bladder cancer is the tenth most frequently diagnosed cancer globally. Classification of high- or low-grade tumors is based on cytological differentiation and is an important prognostic factor. LncRNAs regulate gene expression and play critical roles in the occurrence and development of cancer, however, there are few reports on their diagnostic value and co-expression levels with genes, which may be useful as specific biomarkers for prognosis and therapy in bladder cancer. Thus, we performed a marker lesion study to investigate whether gene/lncRNA expression in urothelial carcinoma tissues may be useful in differentiating low-grade and high-grade tumors. RT-qPCR was used to evaluate the expression of the JHDM1D gene and the lncRNAs CTD-2132N18.2, SBF2-AS1, RP11-977B10.2, CTD-2510F5.4, and RP11-363E7.4 in 20 histologically diagnosed high-grade and 10 low-grade tumors. A protein-to-protein interaction network between genes associated with JHDM1D gene was constructed using STRING website. The results showed a moderate (positive) correlation between CTD-2510F5.4 and CTD2132N18.2. ROC curve analyses showed that combined JHDM1D and RP11-363E7.4 predicted tumor grade with an AUC of 0.826, showing excellent accuracy. In conclusion, the results indicated that the combined expression of JHDM1D and RP11-363E7.4 may be a prognostic biomarker and a promising target for urothelial tumor therapy

Operationalizing mild cognitive impairment criteria in small vessel disease: The VMCI-Tuscany Study

Introduction Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD

Mesenchymal stem cell therapy promotes the improvement and recovery of renal function in a preclinical model

Abstract Acute renal failure (ARF) is an extremely important public health issue in need of novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem cell (MSC) therapy to promote the improvement and recovery of renal function in a preclinical model. Wistar rats were used as the experimental model, and our results show that cisplatin (5mg/kg) can efficiently induce ARF, as measured by changes in biochemical (urea and creatinine) and histological parameters. MSC therapy performed 24h after the administration of chemotherapy resulted in normalized plasma urea and creatinine levels 30 and 45d after the onset of kidney disease. Furthermore, MSC therapy significantly reduced histological changes (intratubular cast formation in protein overload nephropathy and tubular hydropic degeneration) in this ARF model. Thus, considering that current therapies for ARF are merely palliative and that MSC therapy can promote the improvement and recovery of renal function in this model system, we suggest that innovative/alternative therapies involving MSCs should be considered for clinical studies in humans to treat ARF

Analysis of Elastic Traffic Effects on WDM Dynamic Grooming Algorithms

Traffic grooming in IP over WDM networks introduces a coupling between the optical layer and the IP layer. Grooming algorithms are normally studied with a very simple traffic model that completely ignores this interaction. This paper compares the performance of two simple grooming algorithms with a traditional, Poisson based traffic model and a more complex one that takes into account the IP traffic elasticity and the inherent interaction between the IP routing and the optical layer. Simulation results, supported by heuristic considerations and a very simple analytical model highlighting the interaction effects, show that ignoring the two layer interaction is not correct and may lead to wrong conclusions. Besides, it is shown that grooming algorithms that ignore the interaction between the IP and the optical routing, can lead to great resource waste, because the IP routing over the virtual, lightpath based topology, has no knowledge of the actual resource use, while the optical layer, when required to open a new lightpath ignores the overall traffic pattern, taking a decision that is based on a local optimum that may negatively affect later decisions

GANCLES: A Network Level Simulator to Study Optical Routing, Wavelength Assignment and Grooming Algorithms

A novel tool for the study of IP over WDM networks is presented. The tool is a network level simulator named GANCLES that includes several innovative features allowing the study of realistic scenarios in IP over WDM networks, making it an ideal tool for traffic engineering purposes. GANCLES architecture enables the simulation of dynamic traffic grooming on top of a realistic network model that correctly describes the logical interaction between the optical and the IP layer, i.e., the mutual relationship between routing and lightpath assignment procedures at the optical layer and routing at the IP layer. Adding or removing lightpaths changes the logical IP topology, which affects IP routing and traffic patterns. In addition it is possible to use also realistic TCP-like traffic models that mimic the adaptability to the available resources of current data applications, making the overall simulation scenario very realistic and suited both for network analysis and planning/provisioning, either for WANs or for emerging metropolitan optical networks. Samples of the simulator capabilities are given at the end of the report

Field-tests per la realizzazione di HotSpot con reti 802.11

Nel periodo da Ottobre 2003 a Marzo 2004 sono state effettuate delle misurazioni per valutare le caratteristiche e le prestazioni di reti wireless interne e esterne all'Università. In particolare si sono effettuate misurazioni su alcune reti wireless 802.11b non utilizzabili da utenti esterni per valutare le prestazioni in base all'insieme di set di canali utilizzati dagli Access Point. In seguito si sono fatti sopralluoghi nella biblioteca civica di via Roma a Trento per testare la rete wireless installata prima di fornire il servizio al pubblico