The Silmee™ Bar type Lite (TDK, Tokyo, Japan) device.

This biosensor automatically calculates heartbeat intervals, pulse wave intervals, and autonomic nerve activity by measuring and analyzing electrocardiograms, pulse waves, acceleration, and/or skin temperature.</p

Raw data.

(PDF)</p

Demographics of the study population.

Demographics of the study population.</p

Heart rate variability.

Heart rate variability.</p

The effect of instilling the ophthalmic solution on the LF/HF ratio and typical cases of fluctuations in the LF/HF ratio over time in the DE and non-DE groups.

(A) The LF/HF ratio pre- and post-instillation of ophthalmic solution in the DE and non-DE groups. There are no significant changes in either the DE or non-DE groups (P > 0.05). (B) The standard deviation of the LF/HF ratio pre- and post-instillation of ophthalmic solution in the DE and non-DE groups. The standard deviation of the LF/HF ratio significantly decreased post-instillation in the DE group (P < 0.05), whereas it was low pre-instillation and increased post-instillation in the non-DE group. (C) Typical DE and non-DE cases show fluctuation of the LF/HF ratio over time. The DE case presented is of a 39-year-old woman with a J-OSDI score of 18.8 points. The non-DE case is of a 21-year-old woman with a J-OSDI score of 9.1 points. The fluctuation in the LF/HF ratio of the DE case is larger than of the non-DE case, and it decreases post-instillation. DE, dry eye; HF, high-frequency component; J-OSDI, Japanese version of the Ocular Surface Disease Index Questionnaire; LF, low-frequency component.</p

Multiple regression analysis for determining factors affecting the J-OSDI scores.

Multiple regression analysis for determining factors affecting the J-OSDI scores.</p