4,414 research outputs found

    In Santa Fe during the Mexican Regime

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    The Last Word on Montezuma

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    The history of Swanzey, New Hampshire, from 1734 to 1890.

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    Includes index.; Genealogies : p. [269]-504; Biographical and supplementary : p. 505-573

    Site-intensive methods: Fenno and Scott in search of coalition

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    The methods that generally go under the labels ethnography and participant-observation occupy a somewhat awkward place in political science (Bayard de Volo and Schatz 2004). Our discipline lays claim to prominent, if rather isolated, examples of scholarly work based on these methods—with perhaps the two most widely read being Fenno’s Home Style (1978) and Scott’s Weapons of the Weak (1985). A subset of empirical researchers has always been drawn to them, going back at least as far as the immediate post-WWII generation and presumably earlier (Banfield 1958). They are discussed on the occasional conference panel. They are actively employed in much exciting research today, by themselves or in conjunction with other methods (examples include Adams 2003, Allina-Pisano, 2004, Bayard de Volo 2001, Cammett 2005 and 2007, Chen 2006, Galvan 2004, Morris MacLean 2004, Roitman 2004, Schatz 2004, Straus 2006, and Tsai 2007)

    Tidal deformability of neutron stars with realistic equations of state and their gravitational wave signatures in binary inspiral

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    The early part of the gravitational wave signal of binary neutron star inspirals can potentially yield robust information on the nuclear equation of state. The influence of a star's internal structure on the waveform is characterized by a single parameter: the tidal deformability lambda, which measures the star's quadrupole deformation in response to the companion's perturbing tidal field. We calculate lambda for a wide range of equations of state and find that the value of lambda spans an order of magnitude for the range of equation of state models considered. An analysis of the feasibility of discriminating between neutron star equations of state with gravitational wave observations of the early part of the inspiral reveals that the measurement error in lambda increases steeply with the total mass of the binary. Comparing the errors with the expected range of lambda, we find that Advanced LIGO observations of binaries at a distance of 100 Mpc will probe only unusually stiff equations of state, while the proposed Einstein Telescope is likely to see a clean tidal signature.Comment: 12 pages, submitted to PR

    Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release

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    Funding: This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) [Grant BB/M010996/1] via an EASTBIO Doctoral Training Partnership studentship to B.J.R.Heavy-isotope substitution into enzymes slows down bond vibrations and may alter transition-state barrier crossing probability if this is coupled to fast protein motions. ATP phosphoribosyltransferase from Acinetobacter baumannii is a multi-protein complex where the regulatory protein HisZ allosterically enhances catalysis by the catalytic protein HisGS. This is accompanied by a shift in rate-limiting step from chemistry to product release. Here we report that isotope-labelling of HisGS has no effect on the nonactivated reaction, which involves negative activation heat capacity, while HisZ-activated HisGS catalytic rate decreases in a strictly mass-dependent fashion across five different HisGS masses, at low temperatures. Surprisingly, the effect is not linked to the chemical step, but to fast motions governing product release in the activated enzyme. Disruption of a specific enzyme-product interaction abolishes the isotope effects. Results highlight how altered protein mass perturbs allosterically modulated thermal motions relevant to the catalytic cycle beyond the chemical step.Peer reviewe

    Models of helically symmetric binary systems

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    Results from helically symmetric scalar field models and first results from a convergent helically symmetric binary neutron star code are reported here; these are models stationary in the rotating frame of a source with constant angular velocity omega. In the scalar field models and the neutron star code, helical symmetry leads to a system of mixed elliptic-hyperbolic character. The scalar field models involve nonlinear terms that mimic nonlinear terms of the Einstein equation. Convergence is strikingly different for different signs of each nonlinear term; it is typically insensitive to the iterative method used; and it improves with an outer boundary in the near zone. In the neutron star code, one has no control on the sign of the source, and convergence has been achieved only for an outer boundary less than approximately 1 wavelength from the source or for a code that imposes helical symmetry only inside a near zone of that size. The inaccuracy of helically symmetric solutions with appropriate boundary conditions should be comparable to the inaccuracy of a waveless formalism that neglects gravitational waves; and the (near zone) solutions we obtain for waveless and helically symmetric BNS codes with the same boundary conditions nearly coincide.Comment: 19 pages, 7 figures. Expanded version of article to be published in Class. Quantum Grav. special issue on Numerical Relativit