Klotho and FGF23 levels in patients with and without atrial fibrillation.

<p>Klotho and FGF23 levels in patients with and without atrial fibrillation.</p

Klotho (A) and FGF23 (B) levels in controls versus hemodialysis patients.

<p>Klotho (A) and FGF23 (B) levels in controls versus hemodialysis patients.</p

Regression analysis for Klotho tertiles with the absence of atrial fibrillation.

<p>*Model 1: adjusted for age and gender.</p>†<p>Model 2: adjusted for covariates in Model 1 plus diabetes mellitus, coronary artery disease, valvular heart disease, peripheral vascular disease, stroke and anuria.</p>‡<p>Model 3: adjusted for covariates in Model 2 plus parathyroid hormone, fibroblast growth factor 23, calcium, phosphate, albumin, calcium dialysate, potassium serum and dialysate, hemoglobin C-reactive protein, cholesterol and thyroid stimulating hormone.</p><p>Abbreviations: CI, confidence interval; OR, odds ratio.</p

Cumulative survival by tertiles of secreted Klotho.

<p>Patients were stratified by their baseline Klotho levels according to the tertiles. Kaplan-Meier analysis with long-rank test did not reveal a significant difference between groups (P = 0.42).</p

Baseline characteristics and laboratory parameters according to Klotho tertiles.

<p>Plus-minus values are means ± SD. Numbers with ranges in square brackets are medians and interquartile ranges. P values are for the comparisons between the three Klotho tertiles. To convert the values for calcium to milligrams per deciliter, multiply by 4.000. To convert the values for phosphate to milligrams per deciliter, multiply by 3.0969.</p><p>*The body-mass index is the weight in kilograms divided by the square of the height in meters.</p>†<p>Based on 166 available clinically indicated transthoracic echocardiography results.</p><p><b>Abbreviations:</b> ACE-I, angiotensin-converting enzyme inhibitors; AF, atrial fibrillation; AP, alkaline phosphatase; ARB, angiotensin receptor blocker; COPD, chronic obstructive pulmonary disease; FGF23, fibroblast growth factor 23; ICD, implantable cardioverter defibrillator; IQR, interquartile range; PTFE, Polytetrafluorethylen; PTH, parathyroid hormone; PKD, polycystic kidney disease; PVD Peripheral vascular disease; T, Tertile; U, unit.</p

Cumulative survival by tertiles of Fibroblast growth factor 23 (FGF23).

<p>Patients were stratified by their FGF23 levels according to the tertiles. Kaplan-Meier analysis with long-rank test approached a significant difference between groups (P = 0.05).</p

Univariate correlations (Pearson's r) of the plasma troponin concentration with general and dialysis-specific parameters (n = 210–239).

#<p>p<0.10, ^* p<0.05, ^** p<0.01, ^*** p<0.001, n.s.  =  not significant (p>0.10).</p

Patient characteristics of the cohort (n = 239).

<p>Values shown are the median and interquartile range. N indicates number of patients from which data were available.</p><p>abbreviations:</p><p>PTFE  =  polytetrafluorethylene, LV  =  left ventricle, AICD  =  automated implantable cardioverter-defibrillator.</p

Depiction of the plasma troponin I and T concentrations in the cohort.

<p><b>A</b> Box-and-Whiskers-Plot of the plasma troponin I and T concentrations indicating the median, interquartile range and the range between the 2.5^th and 97.5^th percentile. Solid lines represent the 99^th percentile of the assay <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047610#pone.0047610-Reichlin1" target="_blank">[19]</a>. <b>B</b> Distribution of the plasma troponin I and T concentrations in the cohort (n = 239). <b>C</b> Box-and-Whiskers-Plot of the plasma troponin I and T concentrations expressed as multiples of the 99^th percentile <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047610#pone.0047610-Reichlin1" target="_blank">[19]</a>. ^*** indicates a significant difference (p<0.0001) between the troponin T and troponin I concentrations.</p

Plot showing the influence of single predictors in the multivariate model for troponin T (A) and troponin I (B).

<p>^# p<0.10, ^* p<0.05, ^** p<0.01, ^*** p<0.001.</p