Shape-based hand recognition approach using the morphological pattern spectrum

We propose the use of the morphological pattern spectrum, or pecstrum, as the base of a biometric shape-based hand recognition system. The system receives an image of the right hand of a subject in an unconstrained pose, which is captured with a commercial flatbed scanner. According to pecstrum property of invariance to translation and rotation, the system does not require the use of pegs for a fixed hand position, which simplifies the image acquisition process. This novel feature-extraction method is tested using a Euclidean distance classifier for identification and verification cases, obtaining 97% correct identification, and an equal error rate (EER) of 0.0285 (2.85%) for the verification mode. The obtained results indicate that the pattern spectrum represents a good featureextraction alternative for low- and medium-level hand-shape-based biometric applications

Shape-based hand recognition approach using the morphological pattern spectrum

We propose the use of the morphological pattern spectrum, or pecstrum, as the base of a biometric shape-based hand recognition system. The system receives an image of the right hand of a subject in an unconstrained pose, which is captured with a commercial flatbed scanner. According to pecstrum property of invariance to translation and rotation, the system does not require the use of pegs for a fixed hand position, which simplifies the image acquisition process. This novel feature-extraction method is tested using a Euclidean distance classifier for identification and verification cases, obtaining 97% correct identification, and an equal error rate (EER) of 0.0285 (2.85%) for the verification mode. The obtained results indicate that the pattern spectrum represents a good featureextraction alternative for low- and medium-level hand-shape-based biometric applications

Integración de EPS en mejora de las propiedades de resistencia del pavimento rígido F´c= 280 kg/cm², en el sector el Porvenir, Pacasmayo

La investigación se enfocó en evaluar de manera exhaustiva pavimentos rígidos mediante la incorporación de perlas de poliestireno expandido (EPS) para analizar su impacto en la resistencia y comportamiento del concreto. Se llevaron a cabo pruebas de compresión a los 7, 14 y 28 días, así como pruebas de resistencia a la tracción indirecta. La metodología incluyó la fabricación de probetas con moldes específicos y desmoldado eficiente con compresora de aire. La resistencia a la compresión se evaluó con análisis estadísticos, revelando variaciones significativas entre grupos con diferencias estadísticas notables. En cuanto a la resistencia a la tracción indirecta, se observaron disminuciones con la inclusión de EPS, destacando la necesidad de equilibrar resistencia y trabajabilidad del concreto. El estudio resalta la importancia de considerar cuidadosamente el porcentaje de EPS en la formulación del concreto, concluyendo que este factor es crucial para mejorar las propiedades de resistencia del pavimento. Además, ofrece pautas para el diseño de infraestructuras viales sostenibles, enfatizando la optimización de proporciones y la necesidad de estudios a largo plazo y monitoreo continuo en situaciones reales para la implementación efectiva de pavimentos rígidos con EPS

Diagnóstico de barreras del turismo accesible para personas con discapacidad física en entornos culturales del distrito de Sechura, Piura – 2024

La presente investigación titulada Diagnóstico de barreras del turismo accesible para personas con discapacidad física en entornos culturales del distrito de Sechura, Piura – 2024, tiene como objetivo general diagnosticar las barreras de accesibilidad en los entornos culturales de Sechura, para el desarrollo del turismo accesible. Mediante un enfoque mixto y un diseño exploratorio secuencial, se utilizaron como instrumentos un cuestionario y una guía de observación. Se tomaron en cuenta los ODS 10, reducción de desigualdades y la ODS 8 trabajo decente y crecimiento económico. La investigación identificó que, aunque Sechura presenta un avance en accesibilidad en ciertos entornos, persisten barreras en términos de infraestructura, espacios como la Iglesia San Martín de Tours y el Museo Etnológico, además en cuanto a la información turística, se detectó insuficiencia de guiado especializado, elementos bilingües y recursos informativos, a nivel de barreras sociales la falta de capacitación para un guiado especializado limita la atención adecuada a personas con discapacidad. Estos resultados evidencian que, a pesar de ciertos progresos, Sechura aún enfrenta desafíos estructurales, comunicativos y sociales para lograr un turismo verdaderamente accesible. Se concluye que fortalecer la infraestructura, capacitar al personal y sensibilizar a los actores involucrados son acciones clave para un turismo accesible

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

Mutations in the gene coding for Sequestosome 1 (SQSTM1) have been genetically associated with amyotrophic lateral sclerosis (ALS) and Paget disease of bone. In the present study, we analyzed the SQSTM1 coding sequence for mutations in an extended cohort of 1,808 patients with frontotemporal lobar degeneration (FTLD), ascertained within the European Early-Onset Dementia consortium. As control dataset, we sequenced 1,625 European control individuals and analyzed whole-exome sequence data of 2,274 German individuals (total n = 3,899). Association of rare SQSTM1 mutations was calculated in a meta-analysis of 4,332 FTLD and 10,240 control alleles. We identified 25 coding variants in FTLD patients of which 10 have not been described. Fifteen mutations were absent in the control individuals (carrier frequency < 0.00026) whilst the others were rare in both patients and control individuals. When pooling all variants with a minor allele frequency < 0.01, an overall frequency of 3.2 % was calculated in patients. Rare variant association analysis between patients and controls showed no difference over the whole protein, but suggested that rare mutations clustering in the UBA domain of SQSTM1 may influence disease susceptibility by doubling the risk for FTLD (RR = 2.18 [95 % CI 1.24-3.85]; corrected p value = 0.042). Detailed histopathology demonstrated that mutations in SQSTM1 associate with widespread neuronal and glial phospho-TDP-43 pathology. With this study, we provide further evidence for a putative role of rare mutations in SQSTM1 in the genetic etiology of FTLD and showed that, comparable to other FTLD/ALS genes, SQSTM1 mutations are associated with TDP-43 pathology

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types