Unusual Red Shift of the Sensor While Detecting the Presence of Cd²⁺ in Aqueous Environment

A norbornene derived 8-hydroxyquinoline (N8HQ) is designed and synthesized. A “turn-on” ratiometric fluorescent response is observed for Cd2+ in aqueous solution upon binding with N8HQ with a characteristic huge red shift of 164 nm. A lowest detection limit of 1.6 nM of Cd2+ is achieved in the presence of other heavy metals

Hierarchical Self-Assembly of Amphiphilic Homopolymer into Unique Superstructures

Supramolecular forces influence the morphologies of self-assemblies. Herein, self-assembled structures of an amphiphilic, norbornene-derived thiobarbiturate homopolymers (p-NTB) are discussed. The newly designed hompolymer shows self-assembled rod-like structures in tetrahydrofuran (THF) solvent. Formation of the rods are governed by hydrogen bonding motifs and amphiphilicity found in the molecular architecture. The solvent polarity controls their organization into cube-like and sphere-like structures at the next length scale. Encapsulation studies of hydrophobic magnetic particles as well as drug molecules into these superstructures demonstrate a novel route to fabricate multifunctional cube-like and sphere-like aggregates

Unusual Red Shift of the Sensor While Detecting the Presence of Cd²⁺ in Aqueous Environment

A norbornene derived 8-hydroxyquinoline (<b>N8HQ</b>) is designed and synthesized. A “turn-on” ratiometric fluorescent response is observed for Cd²⁺ in aqueous solution upon binding with <b>N8HQ</b> with a characteristic huge red shift of 164 nm. A lowest detection limit of 1.6 nM of Cd²⁺ is achieved in the presence of other heavy metals

Unique Emission from Polymer Based Lanthanide Alloys

The incorporation of metal−ligand interactions into macromolecules imparts them with unique and potentially useful properties. We report novel macromolecules prepared via ATRP that contain activated esters for subsequent incorporation of terpyridine. The addition of lanthanide ions (Eu3+and Tb3+) gave metal functionalized polymers that exhibited excellent emission of either pink (Eu3+) or green (Tb3+) light. A unique yellow luminescence was generated when these two different metal ions were incorporated into the same molecular backbone at a 1:1 ratio, producing an alloy. Upon heating above 50 °C, selective thermochromism, from yellow to orange/pink, was observed

Nanomolar detection of hypochlorite in ground water samples by a norbornene-based polymeric sensor via unusual fluorescence turn-on response

Hypochlorite anion has been widely used as a bleaching and disinfecting agent in daily life. Selective and sensitive identification ofOCl-ions from water is very important for researchers. For this purpose, monomeric (NPh), and polymeric (PNPh-Peg) novel fluorescent sensors have been established for the specific and excellently unique sensors that exhibit selective characteristics like excellent resistance to bleaching and a high fluorescence brightness. A multi-functional random polymer (PNPh-Peg) with ICT (intramolecular charge transfer) active para–amino phenol functionality and reactive oxygen species (ROS) responsive, PEG attached are readily prepared via ROMP (ring-opening metathesis polymerization).: An ICT-active random polymer (PNPh-Peg) exhibited an unexpectedly strong cyan blue emission in a water medium compared to that in other common organic solvents, which was dramatically increased by adding a trace amount of NaOCl.: Incorporating PEG moiety in the polymeric backbone increases the water solubility of a copolymer, and the ROS-responsive groups make the polymer a good ROS scavenger. Upon oxidation of the phenol group into carbonyl, both the monomeric (NPh) and polymeric (Norp-PEG oh) sensors showed a selective, noticeable, unusual fluorescence turn-on response towardsanalyteOCl-ions with a very fast response (within three minutes). The detection limit (59.14 nM) and (126.93 nM) were calculated for monomeric and polymeric sensors, respectively. This was a selective, specific oxidation reaction of the completely water-soluble random polymeric sensor (PNPh-Peg) for hypochlorite anions and can be applicable for quantitative measurement of aqueous OCl-. This ICT-active random polymeric molecule (PNPh-Peg) can also be used as a fluorescent sensor for unique OCl- detection from contaminated water by preparing a sensor-coated paper strip. Thus, these multi-functional monomeric (NPh) and polymeric (PNPh-Peg) sensors are anticipated to apply to the environment.</p

pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging

Multifunctional polymeric nanoaggregates could enable targeted cancer therapy and imaging, which eventually facilitate monitoring of the therapeutic effect. A fluorescent nanoaggregate is constructed for theranostic application. Chlorambucil (Chl), a fluorescent inactive chemotherapeutic agent, is covalently attached to the nanoaggregate for therapeutic action. The pyrene (Py) motif is also covalently attached to the nanoaggregates, with the motivation of cancer cell imaging. This nanoaggregate is further functionalized with biotin (Btn) for receptor-mediated drug delivery. The efficiency of this system is evaluated by in vitro cell studies to prove its receptor-mediated internalization as well as theranostic capabilities. This newly designed nanocarrier, Nor–Chl–Py–Btn (Nor, norbornene), has the ability to combine both therapeutic and diagnostic capabilities into a single polymer that offers existing prospects for the development of nanomedicine

pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging

Multifunctional polymeric nanoaggregates could enable targeted cancer therapy and imaging, which eventually facilitate monitoring of the therapeutic effect. A fluorescent nanoaggregate is constructed for theranostic application. Chlorambucil (Chl), a fluorescent inactive chemotherapeutic agent, is covalently attached to the nanoaggregate for therapeutic action. The pyrene (Py) motif is also covalently attached to the nanoaggregates, with the motivation of cancer cell imaging. This nanoaggregate is further functionalized with biotin (Btn) for receptor-mediated drug delivery. The efficiency of this system is evaluated by in vitro cell studies to prove its receptor-mediated internalization as well as theranostic capabilities. This newly designed nanocarrier, Nor–Chl–Py–Btn (Nor, norbornene), has the ability to combine both therapeutic and diagnostic capabilities into a single polymer that offers existing prospects for the development of nanomedicine

pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging

Multifunctional polymeric nanoaggregates could enable targeted cancer therapy and imaging, which eventually facilitate monitoring of the therapeutic effect. A fluorescent nanoaggregate is constructed for theranostic application. Chlorambucil (Chl), a fluorescent inactive chemotherapeutic agent, is covalently attached to the nanoaggregate for therapeutic action. The pyrene (Py) motif is also covalently attached to the nanoaggregates, with the motivation of cancer cell imaging. This nanoaggregate is further functionalized with biotin (Btn) for receptor-mediated drug delivery. The efficiency of this system is evaluated by in vitro cell studies to prove its receptor-mediated internalization as well as theranostic capabilities. This newly designed nanocarrier, Nor–Chl–Py–Btn (Nor, norbornene), has the ability to combine both therapeutic and diagnostic capabilities into a single polymer that offers existing prospects for the development of nanomedicine

pH-Sensitive Nanoaggregates for Site-Specific Drug-Delivery as Well as Cancer Cell Imaging

Multifunctional polymeric nanoaggregates could enable targeted cancer therapy and imaging, which eventually facilitate monitoring of the therapeutic effect. A fluorescent nanoaggregate is constructed for theranostic application. Chlorambucil (Chl), a fluorescent inactive chemotherapeutic agent, is covalently attached to the nanoaggregate for therapeutic action. The pyrene (Py) motif is also covalently attached to the nanoaggregates, with the motivation of cancer cell imaging. This nanoaggregate is further functionalized with biotin (Btn) for receptor-mediated drug delivery. The efficiency of this system is evaluated by in vitro cell studies to prove its receptor-mediated internalization as well as theranostic capabilities. This newly designed nanocarrier, Nor–Chl–Py–Btn (Nor, norbornene), has the ability to combine both therapeutic and diagnostic capabilities into a single polymer that offers existing prospects for the development of nanomedicine

Reversible pH- and Lipid-Sensitive Vesicles from Amphiphilic Norbornene-Derived Thiobarbiturate Homopolymers

Synthesis of a new molecular architecture, an amphiphilic, norbornene-derived thiobarbiturate homopolymer (<b>NTBH</b>), by ring-opening metathesis polymerization (ROMP) and its characterization is discussed. The newly designed hompolymer shows a self-assembled vesicle formation in aqueous solution. Dynamic light scattering and critical aggregation concentration studies confirm the aggregate formation in solution while atomic force microscopy and transmission electron microscopy of the dried sample on the silicon substrate further confirm the vesicular morphologies of these amphiphilic homopolymers. Encapsulation studies of hydrophilic doxorubicin and hydrophobic Nile red suggest the reversible nature of the <b>NTBH</b> vesicles. Dye release studies in acidic and lipophilic environment demonstrate the stimuli-responsive nature of the novel systems. The results demonstrate that these self-assembled <b>NTBH</b> vesicles have great scope in the field of medicine as they symbolize themselves as promising carriers for the stimuli-triggered intracellular delivery of hydrophobic drugs