139 research outputs found

    Application of LIBS in Detection of Antihyperglycemic Trace Elements in Momordica charantia

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    The present study exploits the information based on concentration of trace elements and minerals in understanding the role/mechanism of action of freeze-dried fruit powder suspended in distilled water of Momordica charantia (family: Cucurbitaceae) in diabetes treatment. Laser-induced break down spectroscopy (LIBS) spectra of plant product was recorded under optimized experimental conditions and analyzed. Several atomic lines such as Na, K, Mg, Ca, Fe, Al, etc. have been observed in the LIBS spectra of the above plant product. The concentrations of these minerals are determined by using calibration-free LIBS method. Correlation between the concentration of these elements/minerals and their defined role in diabetes management was studied in normal as well as diabetic animal model

    The glycemic elemental profile of trichosanthes dioica: a LIBS-based study

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    The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000, and 1,250 mg/kg body weight (bw), were administered orally, and it was observed that the blood glucose concentration decreased in a dose-dependent manner. The dose of 1,000 mg/kg bw showed the maximum fall of 23.8% and 19.1% in blood glucose level (BGL) during fasting BGL and glucose tolerance test (GTT) studies, respectively, of nondiabetic rats. Whereas in the case of subdiabetic and mild diabetic models, the same dose showed reduction in BGL of 22.0% and 31.4% during GTT. The study also involves the first use of laser-induced breakdown spectroscopy as a sensitive analytical tool to detect the elemental profile responsible for the antidiabetic activity of aqueous extract of T. dioica fruits that exhibits the antidiabetic activity. High intensities of Ca, Mg, and Fe indicate large concentrations of these elements in the extract, since according to Boltzmann’s distribution law, intensities are directly proportional to concentrations. The higher concentrations of these glycemic elements, viz. Ca, Mg, and Fe, are responsible for the antidiabetic potential of T. dioica as well as other plant already reported by our research group

    LIBS-Based Detection of Antioxidant Elements in Seeds of Emblica officinalis

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    The aim of the study was to determine the effect of the elements of the extract of seed from Emblica officinalis on antioxidant enzymes and osmotic fragility of erythrocytes membrane in normal as well as streptozotocin-induced severely diabetic albino Wister rats. The results revealed that the untreated diabetic rats exhibited increase in oxidative stress as indicated by significantly diminished activities of free radical scavenging enzymes such as catalase (CAT) and superoxide dismutase (SOD) by 37.5% (p

    Development of Livelihood Index for Different Agro-Climatic Zones of India

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    A livelihood index has been developed for different agro-climatic zones of India, based on the secondary data for TE 2003. Six different sub-indices obtained are indicators of Infrastructure Status, Agricultural Status, Nutritional Status, Economic Status, Health and Sanitation Status and Food Availability Status in respective zones. A total of 57 variables have been considered for this study. Finally, a composite integrated livelihood index has been developed which indicates the livelihood status of different agro-climatic zones in the country. Also, 103 districts of low agricultural productivity have been identified within low livelihood regions. The results of this study have been compared with those of backward districts identified under Wage Employment Program by the Task Force of Planning Commission of India. It is found that about 60 per cent districts identified in this study are the same as identified by the Task Force. Further, the spatial distributions of the identified districts under the study have been mapped using GIS maps and it has been observed that almost same region of the country has been found to be most backward in both the studies. The study has revealed regional disparity in the development process and has suggested to formulate appropriate policies to bridge this disparity gap.Productivity Analysis, Resource /Energy Economics and Policy,

    Oilseed brassica in India: Demand, supply, policy perspective and future potential☆

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    India is the largest agrarian subcontinent supporting 26% world’s agricultural population on 12% arable land. India is also the fifth largest vegetable oil economy accounting 7.4% oilseeds, 5.8% oils and 6.1% oil meal production, and 9.3% of edible oil consumption in the world. Oilseeds are the second most important agricultural economy in India next to cereals growing at a pace of 4.1% per annum in the last three decades. Oilseed brassica shares 23.5% area and 24.2% production of total oilseeds in the country. Despite being the third largest producer (11.3%) of oilseed brassica after Canada and China in the world, India meets 57% of the domestic edible oil requirements through imports and ranked 7th largest importer of edible oils in the world. Oilseed brassica achieved significant growth in India in the past, however, the productivity levels are still low owing to large cultivation under rainfed situation, biotic and abiotic stresses, and resources crunch. It is also facing the challenges of low genotypic potential, climate change and price fluctuation. Though, it embraces the immense scope to increase the production in traditional and non-traditional areas in India with proper inputs, technological interventions, and suitable policy framework. This needs to develop strategies in a well-planned, targeted manner with multi-scientific inputs, policy interface and stable price systems to bring the desired growth in oilseeds brassica production, and to reduce the import of edible oils in the country

    Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV

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    We report the STAR measurement of Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV. Using the event mixing technique, the Phi spectra and yields are obtained at mid-rapidity for five centrality bins in Au+Au collisions and for non-singly-diffractive p+p collisions. It is found that the Phi transverse momentum distributions from Au+Au collisions are better fitted with a single-exponential while the p+p spectrum is better described by a double-exponential distribution. The measured nuclear modification factors indicate that Phi production in central Au+Au collisions is suppressed relative to peripheral collisions when scaled by the number of binary collisions. The systematics of versus centrality and the constant Phi/K- ratio versus beam species, centrality, and collision energy rule out kaon coalescence as the dominant mechanism for Phi production.Comment: 6 pages, 3 figures, submitted to Phys. Rev. Let

    Identification of new susceptibility loci for osteoarthritis (arcOGEN):a genome-wide association study

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    To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Osteoarthritis has a strong genetic component but the success of previous genetic studies has been restricted due to insufficient sample sizes and phenotype heterogeneity. We undertook a large genome-wide association study (GWAS) in 7410 unrelated and retrospectively and prospectively selected patients with severe osteoarthritis in the arcOGEN study, 80% of whom had undergone total joint replacement, and 11,009 unrelated controls from the UK. We replicated the most promising signals in an independent set of up to 7473 cases and 42,938 controls, from studies in Iceland, Estonia, the Netherlands, and the UK. All patients and controls were of European descent. We identified five genome-wide significant loci (binomial test p≤5·0×10(-8)) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1·12 [95% CI 1·08-1·16]; p=7·24×10(-11)), which is in perfect linkage disequilibrium with rs11177. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies. Other significant loci were on chromosome 9 close to ASTN2, chromosome 6 between FILIP1 and SENP6, chromosome 12 close to KLHDC5 and PTHLH, and in another region of chromosome 12 close to CHST11. One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight-a strong risk factor for osteoarthritis. All risk variants were common in frequency and exerted small effects. Our findings provide insight into the genetics of arthritis and identify new pathways that might be amenable to future therapeutic intervention.Arthritis Research UK 1803

    ρ\u3csup\u3e0\u3c/sup\u3e production and possible modification in Au + Au and p + p collisions at √s\u3csub\u3eNN\u3c/sub\u3e = 200 GeV

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    We report results on ρ(770)0→π+π− production at midrapidity in p+p and peripheral Au+Au collisions at √sNN=200  GeV. This is the first direct measurement of ρ(770)0→π+π− in heavy-ion collisions. The measured ρ0 peak in the invariant mass distribution is shifted by ∼40  MeV/c2 in minimum bias p+p interactions and ∼70  MeV/c2 in peripheral Au+Au collisions. The ρ0 mass shift is dependent on transverse momentum and multiplicity. The modification of the ρ0 meson mass, width, and shape due to phase space and dynamical effects are discussed
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