Shared Epitope Allele Stratified Model.

<p>Shared Epitope Allele Stratified Model.</p

Association between Cigarette Pack-Years and Log High Attenuation Volume.

<p>Association between Cigarette Pack-Years and Log High Attenuation Volume.</p

CT Densitometry by Smoking History.

<p>CT Densitometry by Smoking History.</p

CT Densitometry by Smoking History, Controlled for Emphysema%.

<p>CT Densitometry by Smoking History, Controlled for Emphysema%.</p

Study sample.

<p>Study sample.</p

Mean RV and LV measures stratified by gender.

<p>Mean RV and LV measures stratified by gender.</p

Cox proportional hazards models for RV measures and time to dyspnea.

*<p>All hazard ratios correspond to ∼1 SD decrement in the respective RV measure (4 g for mass, 20 cc for volumes, 6% in RVEF).</p>†<p>Adjusted model includes: age, race/ethnicity, education, body mass index, waist size, hip size, smoking status, diastolic blood pressure, hypertension, creatinine, and IL-6.</p

Characteristics of study population.

<p>Characteristics of study population.</p

Mean spirometry, urine cotinine, and percent emphysema values, stratified by gender.

<p>Mean spirometry, urine cotinine, and percent emphysema values, stratified by gender.</p

Associations between SSRI use and RV measures in limited and adjusted models, stratified by sex for RV mass and RVEDV.

<p>*Adjusted for age, sex, race/ethnicity, height, weight, and level of education.</p>†<p>Adjusted for age, sex, race/ethnicity, height, weight, level of education, depression (Center for Epidemiologic Studies.</p><p>Depression-Scale (CES-D) ≥16), smoking (status and pack-years), hypertension, systolic and diastolic blood pressure, cholesterol, low-density lipoprotein levels, triglycerides, and statin use.</p