Assessing the odds of achieving the MDGs

How many countries are on target to achieve the Millennium Development Goals by 2015? How many countries are off target, and how far are they from the goals? And what factors are essential for improving the odds that off-target countries can reach the goals? This paper examines these questions and takes a closer look at the diversity of country progress. The authors argue that the answers from the available data are surprisingly hopeful. In particular, two-thirds of developing countries are on target or close to being on target for all the Millennium Development Goals. Among developing countries that are falling short, the average gap of the top half is about 10 percent. For those countries that are on target, or close to it, solid economic growth and good policies and institutions have been the key factors in their success. With improved policies and faster growth, many countries that are close to becoming on target could still achieve the targets in 2015 or soon after.Population Policies,E-Business,Achieving Shared Growth,Primary Education,Country Strategy&Performance

Las Redes de Petri y su Aplicacion en la Administracion de Empresas

99 p.El proyecto consiste en el estudio y aplicación de una herramienta de modelación de sistemas para la representación de procesos administrativos, las Redes de Petri. A la fecha han sido utilizadas, fundamentalmente, en el ámbito de los sistemas de tiempo real, tales como los sistemas de manufactura y otros caracterizados por la concurrencia de procesos, existiendo escasos antecedentes en materia de aplicación en el ámbito de la Administración de Empresas. Considerando que muchas de las actividades que se Ilevan a cabo dentro de una organización son de carácter repetitivo, condicionales y concurrentes de forma similar a los sistemas anteriormente señalados, el proyecto apunta a profundizar el estudio de las redes de Petri con el propósito de utilizarla como herramienta de apoyo para modelar estas actividades

Transformação ambiental de um estuário industrializado no século XIX: o registo sedimentar de Avilés (Asturias, N Espanha)

ABSTRACT: The Avilés estuary is one of the most important industrial ports in northern Spain, whose natural characteristics have been largely altered since the 1830s. Here, the environmental transformation of this estuary during the 19th century is explored using a multi-proxy approach including benthic foraminiferal content, sedimentology (grain-size), trace metals and short-lived radionuclides (210Pb and 137Cs) analysed from a 50-cm-long sediment core and a surface sample collected from the middle part of the estuary in the Pedro Menéndez Channel. The obtained results provide evidence that indicate an evolution from a naturally-driven environment with high a marine influence towards a more restricted setting under brackish conditions. The observed environmental change is interpreted as being mostly derived from physical modifications linked to the marsh reclamation and channelling starting in 1833 and intensified since 1860. This study provides a preindustrial environmental reference framework for future studies in coastal areas of the NW Atlantic Iberian margin.RESUMO: O estuário de Avilés é um dos portos industriais mais importantes do norte de Espanha, cujas características naturais foram bastante alteradas desde 1830. A transformação ambiental deste estuário durante o século XIX é estudada usando uma abordagem multi-proxy incluindo foraminíferos bentónicos, sedimentologia (dimensão do grão), metais traço e radionuclídeos de vida curta (210Pb e 137Cs) analisados a partir de sedimento de um testemunho de sondagem com 50 cm de comprimento e uma amostra recolhida à superfície na parte média do estuário do Canal de Pedro Menéndez. Os resultados obtidos fornecem evidências que indicam evolução de um ambiente com elevada influência marinha para um ambiente mais restrito em condições salobras. A alteração ambiental observada é interpretada como resultado de modificações físicas ligadas à recuperação e canalização de pântanos a partir de 1833, e intensificada desde 1860. Este estudo fornece um exemplo de referência ambiental pré-industrial para estudos futuros em áreas costeiras da margem NW Ibérica do Atlântico.info:eu-repo/semantics/publishedVersio

Reconstruction of primary vertices at the ATLAS experiment in Run 1 proton–proton collisions at the LHC

This paper presents the method and performance of primary vertex reconstruction in proton–proton collision data recorded by the ATLAS experiment during Run 1 of the LHC. The studies presented focus on data taken during 2012 at a centre-of-mass energy of √s=8 TeV. The performance has been measured as a function of the number of interactions per bunch crossing over a wide range, from one to seventy. The measurement of the position and size of the luminous region and its use as a constraint to improve the primary vertex resolution are discussed. A longitudinal vertex position resolution of about 30μm is achieved for events with high multiplicity of reconstructed tracks. The transverse position resolution is better than 20μm and is dominated by the precision on the size of the luminous region. An analytical model is proposed to describe the primary vertex reconstruction efficiency as a function of the number of interactions per bunch crossing and of the longitudinal size of the luminous region. Agreement between the data and the predictions of this model is better than 3% up to seventy interactions per bunch crossing

Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview

Purpose of Review Review building of programs to eliminate Toxoplasma infections. Recent Findings Morbidity and mortality from toxoplasmosis led to programs in USA, Panama, and Colombia to facilitate understanding, treatment, prevention, and regional resources, incorporating student work. Summary Studies foundational for building recent, regional approaches/programs are reviewed. Introduction provides an overview/review of programs in Panamá, the United States, and other countries. High prevalence/risk of exposure led to laws mandating testing in gestation, reporting, and development of broad-based teaching materials about Toxoplasma. These were tested for efficacy as learning tools for high-school students, pregnant women, medical students, physicians, scientists, public health officials and general public. Digitized, free, smart phone application effectively taught pregnant women about toxoplasmosis prevention. Perinatal infection care programs, identifying true regional risk factors, and point-of-care gestational screening facilitate prevention and care. When implemented fully across all demographics, such programs present opportunities to save lives, sight, and cognition with considerable spillover benefits for individuals and societies

Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances “Take a Village”

Purpose of Review Review international efforts to build a global public health initiative focused on toxoplasmosis with spillover benefits to save lives, sight, cognition and motor function benefiting maternal and child health. Recent Findings Multiple countries’ efforts to eliminate toxoplasmosis demonstrate progress and context for this review and new work. Summary Problems with potential solutions proposed include accessibility of accurate, inexpensive diagnostic testing, pre-natal screening and facilitating tools, missed and delayed neonatal diagnosis, restricted access, high costs, delays in obtaining medicines emergently, delayed insurance pre-approvals and high medicare copays taking considerable physician time and effort, harmful shortcuts being taken in methods to prepare medicines in settings where access is restricted, reluctance to perform ventriculoperitoneal shunts promptly when needed without recognition of potential benefit, access to resources for care, especially for marginalized populations, and limited use of recent advances in management of neurologic and retinal disease which can lead to good outcomes

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Measurements of the Electroweak Diboson Production Cross Sections in Proton-Proton Collisions at root s=5.02 TeV Using Leptonic Decays

The first measurements of diboson production cross sections in proton-proton interactions at a center-of-mass energy of 5.02 TeV are reported. They are based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 302 pb(-1). Events with two, three, or four charged light leptons (electrons or muons) in the final state are analyzed. The WW, WZ, and ZZ total cross sections are measured as sigma(WW) = 37:0(-5.2)(+5.5) (stat)(-2.6)(+2.7) (syst) pb, sigma(WZ) = 6.4(-2.1)(+2.5) (stat)(-0.3)(+0.5)(syst) pb, and sigma(ZZ) = 5.3(-2.1)(+2.5)(stat)(-0.4)(+0.5) (syst) pb. All measurements are in good agreement with theoretical calculations at combined next-to-next-to-leading order quantum chromodynamics and next-to-leading order electroweak accuracy

Search for lepton-flavor violating decays of the Higgs boson in the mu tau and e tau final states in proton-proton collisions at root s=13 TeV

A search is presented for lepton-flavor violating decays of the Higgs boson to mu t and et. The dataset corresponds to an integrated luminosity of 137 fb(-1) collected at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV. No significant excess has been found, and the results are interpreted in terms of upper limits on lepton-flavor violating branching fractions of the Higgs boson. The observed (expected) upper limits on the branching fractions are, respectively, B(H -> mu t) e tau) < 0.22(0.16)% at 95% confidence level.Peer reviewe

Search for top squark pair production using dilepton final states in pp collision data collected at root s=13TeV

A search is presented for supersymmetric partners of the top quark (top squarks) in final states with two oppositely charged leptons (electrons or muons), jets identified as originating from bquarks, and missing transverse momentum. The search uses data from proton-proton collisions at root s = 13 TeV collected with the CMS detector, corresponding to an integrated luminosity of 137 fb(-1). Hypothetical signal events are efficiently separated from the dominant top quark pair production background with requirements on the significance of the missing transverse momentum and on transverse mass variables. No significant deviation is observed from the expected background. Exclusion limits are set in the context of simplified supersymmetric models with pair-produced lightest top squarks. For top squarks decaying exclusively to a top quark and a lightest neutralino, lower limits are placed at 95% confidence level on the masses of the top squark and the neutralino up to 925 and 450 GeV, respectively. If the decay proceeds via an intermediate chargino, the corresponding lower limits on the mass of the lightest top squark are set up to 850 GeV for neutralino masses below 420 GeV. For top squarks undergoing a cascade decay through charginos and sleptons, the mass limits reach up to 1.4 TeV and 900 GeV respectively for the top squark and the lightest neutralino.Peer reviewe