Appendix – Supplemental material for An analytical model for crack monitoring of the shape memory alloy intelligent concrete

Supplemental material, Appendix for An analytical model for crack monitoring of the shape memory alloy intelligent concrete by Bingfei Liu, Qingfei Wang, Kai Yin and Liwen Wang in Journal of Intelligent Material Systems and Structures</p

Early Paleozoic granitoids from South China: implications for understanding the Wuyi-Yunkai orogen

The early Paleozoic Wuyi-Yunkai orogeny involves voluminous magmatism and represents the first major tectonothermal event in the South China block since the Neoproterozoic break-up of the Rodinia supercontinent. Here we investigate three representative granitic plutons in Guangxi province of southwest China with a view to understand the magmatic response of the Wuyi-Yunkai orogeny. We present the results of major and trace elements, Sr-Nd isotopes, zircon U-Pb ages and Hf isotope. LA-ICPMS zircon U-Pb geochronology reveals that these plutons emplaced during the early Silurian (441–432 Ma), overlapping with the reported ages of the early Paleozoic magmatism in this orogen. Among the three plutons investigated in this study, the Qinjia pluton is characterized by weakly to strongly peraluminous (A/CNK = 1.0–1.2) nature with SiO2 content varing from 70.6 to 72.3 wt.%. Combined with the relatively high εNd(t) values (−4.9 to −4.2) and εHf(t) values (−2.9 to +6.1), the Qinjia pluton is thought to derive from partial melting of metasedimentary and metabasic rocks and there may exsit juvenile components in magma source. The Damingshan porphyritic granites (SiO2 = 74.8–76.5 wt.%) and Yingqiao granites (SiO2 = 76.5–76.6 wt.%) are strongly peraluminous (A/CNK = 1.1–1.6) and they have negative zircon εHf(t) values (−6.8 to −4.2, −12.8 to −6.1, respectively) and whole-rock εNd(t) values (−6.3 to −6.2, −8.4, respectively). These signatures indicate that the Damingshan and Yingqiao plutons were derived from partial melting of ancient metasedimentary rocks. Combining our data with those from previous studies on the magmatic, sedimentary and metamorphic records of this area, we suggest that the early Paleozoic magmatism is likely associated with lithospheric delamination and the Wuyi-Yunkai orogen is an intracontinental orogen linked to the far-field response to the assembly of the South China block with the Gondwana in the early Paleozoic.</p

Data for: Geochronology, petrology and Sr-Nd-Hf-S isotope geochemistry of the newly-discovered Qixin magmatic Ni-Cu sulfide prospect, southern Central Asian Orogenic Belt, NW China

Data for: Geochronology, petrology and Sr-Nd-Hf-S isotope geochemistry of the newly-discovered Qixin magmatic Ni-Cu sulfide prospect, southern Central Asian Orogenic Belt, NW Chin

Nanostructured Electrode Materials Derived from Metal–Organic Framework Xerogels for High-Energy-Density Asymmetric Supercapacitor

This work successfully demonstrates metal–organic framework (MOF) derived strategy to prepare nanoporous carbon (NPC) with or without Fe₃O₄/Fe nanoparticles by the optimization of calcination temperature as highly active electrode materials for asymmetric supercapacitors (ASC). The nanostructured Fe₃O₄/Fe/C hybrid shows high specific capacitance of 600 F/g at a current density of 1 A/g and excellent capacitance retention up to 500 F/g at 8 A/g. Furthermore, hierarchically NPC with high surface area also obtained from MOF gels displays excellent electrochemical performance of 272 F/g at 2 mV/s. Considering practical applications, aqueous ASC (aASC) was also assembled, which shows high energy density of 17.496 Wh/kg at the power density of 388.8 W/kg. The high energy density and excellent capacity retention of the developed materials show great promise for the practical utilization of these energy storage devices

Heterogeneity of the late Mesozoic lithospheric mantle beneath the Jiaodong Peninsula, eastern North China Craton: a synthesis from geochemistry and Sr-Nd-Pb isotopes of mafic dykes

The Late Mesozoic lithospheric mantle evolution of the Jiaodong Peninsula is crucial for understanding the destruction of the eastern North China Craton (NCC) and large-scale gold mineralization, but it still remains highly controversial. Here, we comprehensively compiled published Late Mesozoic mafic dyke magmatism data from the Jiaodong Peninsula to provide key constraints on the nature and evolution of the lithospheric mantle. Mafic dykes are widely emplaced in the Jiaodong Peninsula and have been divided into two groups (Jiaobei terrane and Sulu orogenic belt); they mainly comprise lamprophyre, dolerite, and gabbro. The ages of the mafic dykes in the Jiaobei terrane are predominantly between 120 and 125 Ma, and those of the Sulu orogenic belt are between 110 and 120 Ma. The Jiaobei and Sulu mafic dykes both have high contents of Mg and compatible elements (Cr, Ni), as well as low SiO2 content; they are characterized by arc-like mafic magma, including enrichment in Large Ion Lithophile Elements and Light Rare Earth Elements, depletion in High Field Strength Elements, high (87Sr/86Sr)i, and low εNd(t), implying a metasomatized lithospheric mantle source. However, the Jiaobei mafic dykes have relatively higher (87Sr/86Sr)i, lower εNd(t), and a larger range of (206Pb/204Pb)i, (208Pb/204Pb)i, and (207Pb/204Pb)i compared with the Sulu mafic dykes. The Jiaobei and Sulu mafic dykes exhibit Ba/Rb ratios of 1.29‒64.39 (average 29.3) and 6.61‒108.28 (average 33.1), respectively, indicating the presence of hornblende in the melts. The high Fe/Mn (>60) and Zn/Fe (>12) ratios of Jiaobei and Sulu mafic dykes indicate the mixed mantle source of peridotite and pyroxenite. But the content of pyroxenite in the mantle source of Jiaobei terrane is higher with wider range of Fe/Mn and Zn/Fe ratios. These features indicate the heterogeneity of the mantle sources of the mafic dykes in the Jiaobei and Sulu regions. It is suggested that both regions originated from the partial melting of hornblende-bearing peridotite, with the addition of more pyroxenite to the mantle source of the Jiaobei terrane compared to Sulu orogenic belt. The mafic dykes have the low Nb/Zr (Jiaobei: 0.024–0.229; Sulu: 0.030–0.166) and Th/Zr ratios (Jiaobei: 0.017–0.081; Sulu: 0.010–0.068), and the high Rb/Y (Jiaobei: 0.347–12.162; Sulu: 0.224–9.600) and low Nb/Y ratios (Jiaobei: 0.202–1.486; Sulu: 0.140–1.322). It implies that the mantle source area in both regions was metasomatized by subducted slab-derived fluids. The increase in (La/Yb)N and decrease in Hf/Sm implies carbonate metasomatism in both regions. In addition, some Jiaobei and Sulu mafic dykes have high Ti/Eu ratios, implying that the silicate metasomatism occurred in the mantle source of both regions. Based on the regional evolution, the lithospheric mantle source in the two regions beneath Jiaodong Peninsula experienced carbonated fluid metasomatism resulting from the subduction of the Palaeo-Asian Ocean plate beneath the northern NCC (ca. ~250 Ma), silicate melt-related metasomatism from subduction of the Yangtze Craton plate beneath the southern NCC (ca. 240‒220 Ma), and oceanic slab-derived fluid metasomatism from the subducted Palaeo-Pacific plate (at 180‒110 Ma). It is believed that the mantle source of Jiaobei terrane had undergone stronger carbonated fluid metasomatism and silicate melt-related metasomatism, compared to Sulu orogenic belt. Moreover, the continental fluid-related metasomatism only occurred in the Sulu orogenic belt. During the Late Mesozoic, the eastern NCC experienced large-scale lithospheric thinning, leading to upwelling of the asthenospheric mantle. The mafic dykes in Jiaobei and Sulu, show different geochemical features, were derived from partial melting of the metasomatized lithospheric mantle through upwelling of the asthenospheric mantle.</p

Geochronology and geochemistry of the palaeoproterozoic mafic dikes in the Jiaobei terrane: implications for tectonic evolution of the Jiao-Liao-Ji Belt, eastern North China Craton

The palaeoproterozoic tectonic/geodynamic evolution of the Jiao-Liao-Ji Belt (JLJB), one of the three representative palaeoproterozoic tectonic units in the North China Craton (NCC), remains controversial. The palaeoproterozoic mafic dikes sampled in the Jiaobei terrane, situated in the southern segment of the JLJB, could provide significant evidence for the JLJB’s evolution. Their LA-ICP-MS zircon U-Pb dating data show that these dikes were emplaced at the period of ~2175 Ma. They have relatively low SiO2 contents and relatively high contents of Al2O3, MgO, Cr, and Ni. Further, they exhibit high field strength elements (HFSE) (e.g. Nb and Ta) depletion and weak Eu anomalies. Also, they show limited initial 87Sr/86Sr ratios (0.700478–0.705069) and low ɛNd(t) values (−2.07 to −0.09) with model ages (TDM1) of 2722–2967 Ma. The magmatic crystal zircons yielded low ɛHf(t) values of −9.22 ~ −3.82 relative to the corresponding Hf model ages of 2627–2870 Ma. These geochemical characteristics of the dikes indicate that they originated via 5–10% partial melting of the North China Craton’s enriched lithospheric mantle within the spinel stability field. In combination with contemporaneous A-type granites, mafic rocks, and other meta-volcanic associations, palaeoproterozoic Jiaobei mafic dikes formed in a back-arc extensional tectonic setting. This further indicates that the JLJB experienced back-arc extending triggered by slab rollback of subducted oceanic plate at ~2175 Ma ago. This study reports new evidence regarding the evolution of Precambrian tectonics of the North China Craton.</p

Geochemical, mineralogical and chronological studies of mafic-intermediate dykes in the Jiaodong Peninsula: implications for Late Mesozoic mantle source metasomatism and lithospheric thinning of the eastern North China Craton

The Late Mesozoic tectonic evolution of the eastern North China Craton (NCC) remains controversial. In this study, a suite of Early Cretaceous mafic-intermediate dyke swarms found in the same section in the Jiaodong Peninsula, eastern NCC, were used to trace the nature of lithospheric mantle and crust–mantle interaction. Zircon U-Pb dating demonstrates that these dykes emplaced into the Jiaodong Peninsula during the same period (112–121 Ma). Diorite dykes have SiO2 contents of 52.7–54.1 wt.%, Na2O+K2O contents of 5.77–6.10 wt.%, a limited range of MgO (4.43–5.13 wt.%), Cr (64.8–85.5 ppm) and Ni (23.6–27.7 ppm), and a narrow range of (87Sr/86Sr)i isotopic ratios (0.709240–0.709246), ƐNd(t) values (−20.0 to −19.1) and ƐHf(t) values (ca. −23.9). Lamprophyre and dolerite dykes have low contents of SiO2 (50.5–55.4 wt.%) and Na2O+K2O (4.88–7.28 wt.%), high contents of Al2O3 (14.6–15.8 wt.%), MgO (5.83–8.60 wt.%), Cr (210–292 ppm) and Ni (114–149 ppm), and a narrow range (87Sr/86Sr)i isotopic ratios (0.709134–0.709788), ƐNd(t) values (−19.9 to −17.4) and ƐHf(t) values (−22.1 to −15.1). Both intermediate and mafic dykes exhibit strong large ion lithophile elements (LILE) enrichment and high field strength element (HFSE) depletion. These geochemical characteristics demonstrate that the magma was primarily derived from relatively low degrees of the partial melting of garnet-lherzolite mantle, which was modified by fluids from a subducting oceanic slab with marine sediments. Both the mafic dykes and intermediate dykes originated from the same magma source and formed in different stages of magma fractionation crystallization. The magma experienced the fractional crystallization of clinopyroxene and more ferromagnesian minerals in a hydrous condition, thus forming mafic dykes. Then, the residual calc-alkaline liquids upwelled into a low-H2O and low-pressure environment, in which more plagioclase crystallized from liquid, thus increasing the degree of differentiation and producing the Ca- and Al-rich diorite dyke. Combined with Late Mesozoic mantle-derived mafic-intermediate dykes and crust-derived volcanic rocks in the region, the eastern NCC has experienced considerable lithospheric thinning along with regional extensional tectonics, which was caused by the prolonged thermo-mechanical-chemical erosion on the lithosphere induced by the rollback of the subducted paleo-Pacific plate.</p

Supplementary document for Real-time image denoising of mixed Poisson-Gaussian noise in fluorescence microscopy images using ImageJ - 5685036.pdf

Supplemental Documen

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance immunotherapy, yet it remains a challenge to identify therapeutic targets highly expressed and functionally essential in TINs but under-expressed in extra-tumoral neutrophils. Here, using single-cell RNA sequencing to compare TINs and circulating neutrophils in murine mammary tumor models, we identified aconitate decarboxylase 1 (Acod1) as the most upregulated metabolic enzyme in mouse TINs and validated high Acod1 expression in human TINs. Activated through the GM-CSF-JAK/STAT5-C/EBPβ pathway, Acod1 produces itaconate, which mediates Nrf2-dependent defense against ferroptosis and upholds the persistence of TINs. Acod1 ablation abates TIN infiltration, constrains metastasis (but not primary tumors), bolsters antitumor T cell immunity, and boosts the efficacy of immune checkpoint blockade. Our findings reveal how TINs escape from ferroptosis through the Acod1-dependent immunometabolism switch and establish Acod1 as a target to offset immunosuppression and improve immunotherapy against metastasis.</p

In Vivo Selection of Highly Metastatic Human Ovarian Cancer Sublines Reveals Role for AMIGO2 in Intra-Peritoneal Metastatic Regulation.

The majority of women with ovarian cancer are diagnosed with metastatic disease, therefore elucidating molecular events that contribute to successful metastatic dissemination may identify additional targets for therapeutic intervention and thereby positively impact survival. Using two human high grade serous ovarian cancer cell lines with inactive TP53 and multiple rounds of serial in vivo passaging, we generated sublines with significantly accelerated intra-peritoneal (IP) growth. Comparative analysis of the parental and IP sublines identified a common panel of differentially expressed genes. The most highly differentially expressed gene, upregulated by 60-65-fold in IP-selected sublines, was the type I transmembrane protein AMIGO2. As the role of AMIGO2 in ovarian cancer metastasis remains unexplored, CRISPR/Cas9 was used to reduce AMIGO2 expression, followed by in vitro and in vivo functional analyses. Knockdown of AMIGO2 modified the sphere-forming potential of ovarian cancer cells, reduced adhesion and invasion in vitro, and significantly attenuated IP metastasis. These data highlight AMIGO2 as a new target for a novel anti-metastatic therapeutic approach aimed at blocking cohesion, survival, and adhesion of metastatic tumorspheres