A signature based on chromatin regulation and tumor microenvironment infiltration in clear cell renal cell carcinoma.

Supplementary figure 1.  extracted significant prognosis-associated CRs using the Kaplan–Meier method based on the TCGA dataset  Supplementary figure 2.  Three CR modification genomic phenotypes were then generated via the k-means algorithm, and these phenotypes were termed as CR gene clusters A–C, respectively  Supplementary table 1.  Extracted significant prognosis-associated CRs using the Kaplan–Meier method based on the TCGA dataset  Supplementary table 2.  Three CR modification genomic phenotypes were then generated via the k-means algorithm, and these phenotypes were termed as CR gene clusters A–C, respectively </p

Tailoring the Degree of Branching: Preparation of Poly(ether ester)s via Copolymerization of Poly(ethylene glycol) Oligomers (A₂) and 1,3,5-Benzenetricarbonyl Trichloride (B₃)

A novel approach to tailor the degree of branching of poly(ether ester)s was developed based on the copolymerization of oligomeric A2 and B3 monomers. A dilute solution of poly(ethylene glycol) (PEG) (A2) was added slowly to a dilute solution of 1,3,5-benzenetricarbonyl trichloride (B3) at room temperature in the presence of triethylamine to prepare high molar mass gel-free products. PEG diols of various molar masses permitted the control of the degree of branching and an investigation of the effect of the distance between branch points. 1H NMR spectroscopy indicated a classical degree of branching (DB) of 69% for a highly branched poly(ether ester) derived from 200 g/mol PEG diol. A revised definition of the degree of branching was proposed to accurately describe the branched poly(ether ester)s, and the degree of branching decreased as the molar mass of the PEG diols was increased. The effects of branching and the length of the PEG segments on the thermal properties of the highly branched polymers were investigated using differential scanning calorimetry (DSC). Amorphous branched poly(ether ester)s were obtained using PEG diols with number-average molar masses of either 200 or 600 g/mol. In-situ functionalization of the terminal acyl halide units with 2-hydroxylethyl acrylate provided novel photo-cross-linkable precursors

Average dose-volume histogram (DVH) comparison for lung and heart with four different planning techniques.

6F-IMRT = six large fields IMRT plans with fixed jaw; 6F-IMRT-T = six large fields IMRT plans with jaw tracking technique; 12F-IMRT = twelve small fields IMRT plans with fixed jaw; 12F-IMRT-T = twelve small fields IMRT plans with jaw tracking technique.</p

The mean doses of organs at risk, MU, beam-on time, and mean dose rate (MDR) for treatment plans created with different planning techniques.

<p><i>Abbreviations:</i> HFF-VMAT-FF = two half-field full-arcs VMAT with conventional flattened (FF) beam; HFQ-VMAT-FF = eight half-field quarter-arcs VMAT with FF beam; HFQ-VMAT-FFF = eight half-field quarter-arcs VMAT with flattening filter free (FFF) beam.</p><p>* Body: it is the region of the CT which was scanned.</p><p>* <i>P</i> value corresponds to the paired <i>t</i> test: a = HFF-VMAT-FF vs HFQ-VMAT-FF, b = HFQ-VMAT-FF vs HFQ-VMAT-FFF.</p><p>The mean doses of organs at risk, MU, beam-on time, and mean dose rate (MDR) for treatment plans created with different planning techniques.</p

Isodose distributions for one patient with esophageal cancer in four treatment plans.

6F-IMRT = six large fields IMRT plans with fixed jaw; 6F-IMRT-T = six large fields IMRT plans with jaw tracking technique; 12F-IMRT = twelve small fields IMRT plans with fixed jaw; 12F-IMRT-T = twelve small fields IMRT plans with jaw tracking technique.</p

Cumulative survival of patients stratified by the number of lymph node metastases (pN).

<p>Cumulative survival of patients stratified by the number of lymph node metastases (pN).</p

Planning Study of Flattening Filter Free Beams for Volumetric Modulated Arc Therapy in Squamous Cell Carcinoma of the Scalp - Figure 1

<p><b>Delineated planning target volume (PTV) for squamous cell carcinoma of the scalp (A), and two different beam setups in VMAT plans:</b> (B) Two 360° arcs were used with half-field beam. (C) Eight half-field quarter-arcs (90°) were used in VMAT plan.</p

Comparison of receiver operating characteristic curves based on the metastatic lymph node ratio (MLR) and the number of positive lymph nodes (pN).

<p>Comparison of receiver operating characteristic curves based on the metastatic lymph node ratio (MLR) and the number of positive lymph nodes (pN).</p

The number of monitor units (MU), beam-on time (BOT), and mean dose rate (MDR) for treatment plans created with different planning techniques.

The number of monitor units (MU), beam-on time (BOT), and mean dose rate (MDR) for treatment plans created with different planning techniques.</p

Planning Study of Flattening Filter Free Beams for Volumetric Modulated Arc Therapy in Squamous Cell Carcinoma of the Scalp - Figure 2

<p><b>The beam setup of two designs for VMAT plans in clockwise (CW):</b> (A) HFF-VMAT: two half-field full-arcs VMAT; (B) HFQ-VMAT: eight half-field quarter-arcs VMAT.</p