A Photocatalyzed Cascade Approach Toward the Tetracyclic Core of Akuammiline Alkaloids

A cascade approach toward the tetracyclic core of akuammiline alkaloids which features high modularity and convergence is reported. Distinct substitution pattern can be readily introduced to the tetracyclic core by varying three building blocks with similar complexity. The critical event in the cascade is a regio- and stereoselective 1,2-shift enabled by a carbocation that sets up the core

PhI(OAc)₂‑Mediated Synthesis of 6‑(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2‑Isocyanobiphenyls with CF₃SiMe₃ under Metal-Free Conditions

A mild and efficient method for the synthesis of 6-(trifluoromethyl)phenanthridines through oxidative cyclization of 2-isocyanobiphenyls with CF₃SiMe₃ under metal-free conditions was developed. The reaction allows the direct formation of C–CF₃ bonds and rapid access to phenanthridine ring systems in one catalytic cycle