2 research outputs found

    Table_1_Effects of Liqi Tongbian decoction on gut microbiota, SCFAs production, and 5-HT pathway in STC rats with Qi Stagnation Pattern.DOCX

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    Slow transit constipation (STC) is a common and debilitating condition characterized by delayed colonic transit and difficulty in fecal expulsion, significantly impacting patients’ physical and mental wellbeing as well as their overall quality of life. This study investigates the therapeutic potential of Liqi Tongbian Decoction (LTD) in the treatment of STC, especially in cases involving the context of Qi stagnation, through a multifaceted approach involving the modulation of intestinal flora and short-chain fatty acids (SCFAs). We employed a rat model of STC with Qi Stagnation Pattern, established using the “loperamide + tail-clamping provocation method,” to explore the effects of LTD on fecal characteristics, intestinal motility, and colonic pathology. Importantly, LTD exhibited the ability to increase the richness, diversity, and homogeneity of intestinal flora while also modulating the composition of microorganisms. It significantly increased the production of SCFAs, especially butyric acid. Moreover, LTD exerted a substantial influence on the synthesis of serotonin (5-HT) by modulating the expression of tryptophan hydroxylase (TPH) and interacting with the 5-HT4 receptor (5-HT4R), resulting in enhanced colonic motility. Correlation analyses revealed a positive correlation between certain bacterial genera, such as Lachnospiraceae_NK4A136 spp. and Clostridiales spp. and the concentrations of butyric acid and 5-HT. These results suggest a mechanistic link between microbiome composition, SCFAs production, and 5-HT synthesis. These findings highlight the potential of LTD to alleviate STC by facilitating a beneficial interplay among intestinal flora, SCFAs production, and 5-HT-mediated colonic motility, providing novel insights into the management of STC with Qi Stagnation Pattern.</p

    Gait motion analysis based on WB-4 sensor with quaternion algorithm

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    Up to now, with the increasing of the elderly population, more and more patients are suffering from hemiplegia. The needs for hemiplegic rehabilitation is increasing quickly. As traditional rehabilitation, each patient must be treated by therapist, one by one. However, because of the different levels of therapists, the rehabilitation cannot be performed as the as the same. Normally, the rehabilitation status diagnosing is still be performed by therapists with the subjective experience. It caused the inhomogeneity on rehabilitation evaluation. It also sometimes causes negative influence on the rehabilitation effect. To solve these problems, many researches focusing on assessing the status of the hemiplegic patients quantitatively are proposed rehabilitation evaluation systems. Rehabilitation motion detection is the basis of the evaluation system, and it requires the participation of therapist. In this paper, a method is presented to detect lower limb motion of hemiplegic patients based on inertial sensor technology. The gesture quaternion of lower limb can be obtained through LPMS. With the matrix and Euler angle changing algorithm, combining with the simplified lower limb motion model, the rotation angle of joint can be computed. Finally, the curve of rotation angle of knee is established
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