Wind-Driven Triboelectric Nanogenerators for Scavenging Biomechanical Energy

The wind-driven triboelectric nanogenerator (TENG), considered as one of the most important tributaries of the TENG family, possesses high-frequency signals and remarkable output power. Herein, a wind-driven TENG, employing silver nanowires (Ag NWs) and fluorinated ethylene propylene (FEP) as triboelectric materials, was designed with a purpose to act as a power unit to replace batteries in some wearable devices. Under a wind speed of 20 m/s, the as-fabricated TENG could generate an output voltage, current, and power of up to 150 V, 7.5 μA, and 0.18 mW, respectively. Wind-driven TENGs were integrated into three types of self-powered devices (i.e., shoe, bracelet, and mask) to play roles as energy sources due to the high output power and high-frequency signals. The wearable devices were utilized to monitor different motion states (e.g., walking, jogging, and running) at various body positions. These prototypes of self-powered wearable devices could offer new approaches to protecting our environment and improving the quality of human life

Table_1_Effects of use motivations and alexithymia on smartphone addiction: mediating role of insecure attachment.docx

Background and objectivesConcern exists regarding the potential negative consequences of smartphone addiction among adolescents. This study investigated the effect of use motivations and alexithymia on smartphone addiction among adolescents with two insecure attachment styles, namely, anxious and avoidant attachment. These attachment styles were regarded as mediating variables.MethodsSelf-report measures were used to assess use motivations, alexithymia, insecure attachment and smartphone addiction. Data were collected from 748 junior high school students (382 males and 366 females) in northeastern China. Structural equation modeling was used to test our hypothesis that use motivations and alexithymia are directly associated with smartphone addiction and also through the mediation of attachment insecurities.ResultsThe structural equation modeling results showed a strong and positive correlation between use motivation and smartphone addiction, with avoidant attachment mediating such a relationship. Meanwhile, the two components of alexithymia, difficulty identifying feelings and externally oriented thinking, positively predicted smartphone addiction, with avoidant attachment serving as a mediator of this effect. In addition, the mediation analysis results demonstrated that attachment anxiety mediated the connection between escape drive, extrinsically focused thought, and smartphone addiction.ConclusionFindings describe how attachment insecurities, smartphone use motivations, and alexithymia can interact with one another to predict smartphone addiction. Smartphone use motivation types and alexithymia symptoms should be taken into consideration when designing targeted intervention programs for smartphone addiction to address the different attachment needs of adolescents, which would be helpful to reduce their smartphone addiction behaviors.</p

Ag Nanoparticle-Based Triboelectric Nanogenerator To Scavenge Wind Energy for a Self-Charging Power Unit

Li-ion batteries are a green energy storage technology with advantages of high energy density, long lifetime, and sustainability, but they cannot generate electric energy by themselves. As a novel energy-harvesting technology, triboelectric nanogenerators (TENGs) are a promising power source for supplying electronic devices, however it is difficult to directly use their high output voltage and low output current. Here, we designed a Ag nanoparticle-based TENG for scavenging wind energy. After including a transformer and a power management circuit into the system, constant output voltages such as 3.6 V and a pulsed current of about 100 mA can be obtained, which can be used to directly light up a light-emitting diode. Furthermore, the produced electric energy can be effectively stored in a WO₃/LiMn₂O₄ electrode based Li-ion battery. Our present work provides a new approach to effectively scavenge wind energy and store the obtained electric energy, which is significant for exploring self-charging power units

Table_1_Dermatologic toxicities in epidermal growth factor receptor: a comprehensive pharmacovigilance study from 2013 to 2023.DOCX

Epidermal growth factor receptor inhibitors (EGFRIs) induced cutaneous toxicity is a common adverse event (AE), although it is not as severe as major cancers, we still need to pay enough attention to them. Therefore, it is necessary to evaluate the diversity of EGFRI class drugs. The objective of this study was to conduct a scientific and systematic investigation into the correlation between EGFRI and cutaneous toxicities. The data accessed from the FDA adverse event reporting system database (FAERS) encompass a time frame spanning from January 2013 to March 2023. By utilizing reporting odds ratios (RORs), information components (ICs), proportional reporting ratios (PRRs), and chi-squared (χ2), the relationship between drugs and adverse reactions was evaluated through disproportionality analysis. Within the FAERS database, a total of 29,559 skin adverse events were recorded. A robust indication of the correlation between EGFRI and elderly patients (≥65 years) was identified. Among EGFRIs, erlotinib accounted for the largest proportion of skin adverse events (39.72%). Rash, dry skin, and pruritus ranked top among all preferred terms, and signals such as rash, skin lesions, and acneiform dermatitis were detected in every single drug. Clinicians should guide patients customize the treatment plan for each patient.</p

Additional file 1 of Plant endophytic fungi exhibit diverse biotransformation pathways of mogrosides and show great potential application in siamenoside I production

Supplementary Material

Functional SNPs of <i>INCENP</i> Affect Semen Quality by Alternative Splicing Mode and Binding Affinity with the Target Bta-miR-378 in Chinese Holstein Bulls

<div><p>Inner centromere protein (<i>INCENP</i>) plays an important role in mitosis and meiosis as the main member of chromosomal passenger protein complex (CPC). To investigate the functional markers of the <i>INCENP</i> gene associated with semen quality, the single nucleotide polymorphisms (SNPs) g.19970 A>G and g.34078 T>G were identified and analyzed. The new splice variant <i>INCENP-TV</i> is characterized by the deletion of exon 12. The g.19970 A>G in the exonic splicing enhancer (ESE) motif region results in an aberrant splice variant by constructing two minigene expression vectors using the pSPL3 exon capturing vector and transfecting vectors into MLTC-1 cells. <i>INCENP-TV</i> was more highly expressed than <i>INCENP-reference</i> in adult bull testes. The g.34078 T>G located in the binding region of bta-miR-378 could affect the expression of <i>INCENP</i>, which was verified by luciferase assay. To analyze comprehensively the correlation of SNPs with sperm quality, haplotype combinations constructed by g.19970 A>G and g.34078 T>G, as well as g.-692 C>T and g.-556 G>T reported in our previous studies, were analyzed. The bulls with H1H12 and H2H2 exhibited a higher ejaculate volume than those with H2H10 and H9H12, respectively (<i>P</i> < <i>0</i>.<i>05</i>). Bulls with H11H11 and H2H10 exhibited higher initial sperm motility than those with H2H2 (<i>P < 0</i>.<i>05</i>). The expression levels of <i>INCENP</i> in bulls with H1H12 and H11H11 were significantly higher than those in bulls with H9H12 (<i>P < 0</i>.<i>05</i>), as determined by qRT-PCR. Findings suggest that g.19970 A>G and g.34078 T>G in <i>INCENP</i> both of which appear to change the molecular and biological characteristics of the mRNA transcribed from the locus may serve as a biomarkers of male bovine fertility by affecting alternative splicing mode and binding affinity with the target bta-miR-378.</p></div

Means and standard errors (SE) of sperm quality traits in 307 Chinese Holstein bulls.

<p>Means and standard errors (SE) of sperm quality traits in 307 Chinese Holstein bulls.</p

Diagram representation of the alternative splicing pattern of <i>NCF4</i> transcripts and results of SNP g.18174 A>G sequencing in the retained 48 bp sequence in intron 9 of the bovine <i>NCF4</i> gene.

<p><b>(A)</b> Genomic structure of the bovine <i>NCF4</i> gene. <b>(B)</b> Splicing pattern of the <i>NCF4</i>-<i>TV</i> splice variant and the sequencing result of SNP g.18174 A>G. The <i>NCF4</i>-<i>TV</i> transcript retains a 48 bp sequence from intron 9. The position of the A nucleotide in the start codon (ATG) is defined as +1.</p

The single-nucleotide polymorphism (g.34078 T>G) located in the seed region of bta-miR-378 binding to the 3′-UTR of the bovine <i>INCENP</i> gene.

<p>(A) The bta-miR-378: mRNA of <i>INCENP</i> interaction is shown. The altered allele is highlighted. (B) Computational modeling of the interaction between miR-378 and 3’-UTR that contains g.34078 T>G-T genotype (wild type) or g.34078 T>G-G (mutant type) was performed on RNAHYBRID software online.</p

<i>HIBADH</i> expressed in different bull tissues.

<p>(A) The transcripts of <i>HIBADH</i> were detected by RT-PCR in lung, spleen, heart, testis, epididymis, and ejaculate semen. <i>GAPDH</i> was used as the positive control. (B) Western blot analysis of HIBADH in adult bull tissues and ejaculate (with β-actin as the control).</p