Mo Doping to Modify Lattice and Morphology of the LiNi_0.9Co_0.05Mn_0.05O₂ Cathode toward High-Efficient Lithium-Ion Storage

The Ni-rich Co-poor layered cathode (LiNixCoyMn1–x–yO2, x ≥ 0.9) is a candidate for the next-generation lithium-ion batteries due to its high specific capacity and low cost. However, the inherent structural instability and slow kinetics of Li+ migration hinder their large-scale application. Mo doping is proposed to enhance the crystal structure stability of LiNi0.9Co0.05Mn0.05O2 and to ensure the preservation of the spherical secondary particles after the cycle. The characterization results indicate that Mo doping not only significantly relieves the lattice strain accompanied by H2 → H3 phase transition but also alleviates particle stress accumulation to avoid pulverization. The Mo-modification allows the generation of uniform fine primary particulates and further agglomeration into the smooth secondary particles to inhibit electrolyte penetration. Hence, the Mo-modified sample NCM90-1%Mo displays an excellent capacity retention of 85.9% after 200 cycles at 0.5 C current density, which is 23.8% higher than that of the pristine NCM90. In addition, with the expansion of the Li slab to accelerate Li+ diffusion and the fine primary particles to shorten the Li+ pathway, the NCM90-1%Mo sample exhibits a high discharge capacity of 150 mAh g–1 at 5 C current density. This work provides a new thought for the design and construction of high-capacity cathode materials for the next-generation lithium-ion batteries

Image 1_v1_Hip-preserving reconstruction using a customized cemented femoral endoprosthesis with a curved stem in patients with short proximal femur segments: Mid-term follow-up outcomes.tif

BackgroundShort metaphyseal segments that remain following extensive distal femoral tumor resection can be challenging to manage, as the residual short segments may not be sufficient to accept an intramedullary cemented stem of standard length. The present study was developed to detail preliminary findings and experiences associated with an intra-neck curved stem (INCS) reconstructive approach, with a particular focus on mechanical stability.MethodFrom March 2013 to August 2016, 11 total patients underwent reconstructive procedures using a customized cemented femoral endoprosthesis (CCFE) with an INCS. Measurements of femoral neck-shaft angle values were made before and after this procedure. Radiological outcomes associated with this treatment strategy over an average 63-month follow-up period were additionally assessed. Functionality was assessed based upon Musculoskeletal Tumor Society (MSTS) scores, while a visual analog scale (VAS) was used to rate pre- and postoperative pain, and any complications were noted.ResultsRelative to the preoperative design, no significant differences in femoral neck–shaft angle were observed after this reconstructive procedure (p = 0.410). Postoperatively, the tip of the stem was primarily positioned within the middle third of the femoral head in both lateral and posterior-anterior radiographic, supporting the accuracy of INCS positioning. The average MSTS score for these patients was 25 (range: 21–28), and VAS scores were significantly reduced after surgery (p ConclusionCCFE with an INCS represents a viable approach to massive femoral diaphyseal defect with short proximal femur repair, as patients can achieve good functional outcomes and early weight-bearing with proper individualized rehabilitative interventions, all while exhibiting low rates of procedure-related complications.</p

High-Performance Lossy-Mode Resonance Sensor Based on Few-Layer Black Phosphorus

Surface plasmon resonance (SPR) can be excited only by the transverse magnetic (TM)-polarized light in the conventional SPR sensor, whereas the lossy-mode resonance (LMR) can be achieved with both transverse electric (TE)- and TM-polarized lights. In this work, we propose a high-performance LMR sensor based on few-layer black phosphorus (BP), and the high quality factor (<i>Q</i>) of this BP-based LMR sensor for TE- and TM-polarized lights has been discussed. In comparison with that for the conventional SPR sensor, the <i>Q</i> factor for the proposed BP-based LMR sensor with both TE- and TM-polarized lights has been greatly improved. In particular, the highest <i>Q</i> factor as high as 2 × 10⁵ RIU^–1 can be obtained for the TM-polarized mode

DataSheet_1_The role of protein arginine deiminase 4-dependent neutrophil extracellular traps formation in ulcerative colitis.docx

BackgroundNeutrophil extracellular traps (NETs) play an important role in the development and progression of ulcerative colitis (UC). Peptidyl arginine deiminase 4 (PAD4) is essential for the formation of NETs via catalyzing histone citrullination. This study mainly to explore the role of PAD4-mediated NETs in intestinal inflammation of dextran sulfate sodium (DSS)-induced UC.MethodsAcute and chronic colitis mouse models were established by supplementing DSS in drinking water. Colon tissues from colitis mice were analyzed for the level of PAD4 expression, citrullinated histone H3(Cit-H3), intestinal histopathology, and inflammatory cytokines secretion. Serum samples were tested for systemic neutrophil activation biomarkers. Colitis mice administered with Cl-amidine, a PAD4 inhibitor, and PAD4 knockout mice were investigated to detect NETs formation, intestinal inflammation, and barrier function.ResultWe found the formation of NETs significantly increased in DSS-induced colitis mice and was correlated with disease markers. Blocking NETs formation by Cl-amidine or PAD4 genetic knockout could alleviate clinical colitis index, intestinal inflammation, and barrier dysfunction.ConclusionThis study provided a research basis for the role of PAD4-mediated NETs formation in the pathogenesis of UC and suggested that inhibition of PAD4 activity and the formation of NETs may be helpful for the prevention and treatment of UC.</p

Correlation between Notch1 expression and clinicopathological features in patients with colorectal cancer.

<p>LNM, Lymph node metastasis; TNM, tumor node metastasis.</p

Immunohistochemical staining of Notch1 in colorectal tissues (400×).

<p>a: normal adjacent colorectal specimen. b: ulcerative colitis Notch1-low-expression specimen. c: adenoma Notch1-low-expression specimen. d: Strongly immunoreactive cytoplasmic in a tumor with high Notch1 expression.</p

Kaplan–Meier curves illustrating correlation of Notch1 expression with survival (a) overall survival (OS) (log-rank test, <i>P</i> = 0.001) and (b) disease-free survival (DFS) (log-rank test, <i>P</i><0.001).

<p>Kaplan–Meier curves illustrating correlation of Notch1 expression with survival (a) overall survival (OS) (log-rank test, <i>P</i> = 0.001) and (b) disease-free survival (DFS) (log-rank test, <i>P</i><0.001).</p

Summary of the clinicopathologic features of ulcerative colitis, adenoma and carcinoma patients.

<p>Summary of the clinicopathologic features of ulcerative colitis, adenoma and carcinoma patients.</p

MOESM1 of Prognostic value of plasma DPP4 activity in ST-elevation myocardial infarction

Additional file 1: Table S1. The characteristics of STEMI patients between included and excluded patients

Additional file 7: Figure S1. of Histone modifications facilitate the coexpression of bidirectional promoters in rice

Coexpression analysis of gene pairs associated with BDPs with size separated by every 100 bp intergenic length The Pearson correlation coefficient was calculated from all gene pairs corresponding to BDPs separated every 100 bp using the absolute expression value. Statistical analysis was provided by a two-sample K-S test, where ** p < 0.001, * p < 0.05. (XLS 110 kb