46 research outputs found
The Maize Landcover in 2015 in Northern China
The landcover of maize with a resolution of 30 m in 2015 in the Northern part of China
The Maize Landcover in 2021 in Northern China
The landcover of maize with a resolution of 30 m in 2021 in the Northern part of China
The Maize Landcover in 2017 in Northern China
The landcover of maize with a resolution of 30 m in 2017 in the Northern part of China
The Maize Landcover in 2014 in Northern China
The landcover of maize with a resolution of 30 m in 2014 in the Northern part of China
The Maize Landcover in 2019 in Northern China
The landcover of maize with a resolution of 30 m in 2019 in the Northern part of China
The Maize Landcover in 2018 in Northern China
The landcover of maize with a resolution of 30 m in 2018 in the Northern part of China
The Maize Landcover in 2016 in Northern China
The landcover of maize with a resolution of 30 m in 2016 in the Northern part of China
Extracellular Biocoordinated Zinc Nanofibers Inhibit Malignant Characteristics of Cancer Cell
Inhibition
of the heat shock proteins (HSPs) has been considered to be one of
the promising strategies for cancer treatment. However, developing
highly effective HSP inhibitors remains a challenge. Recent studies
on the evolutionarily distinct functions between intracellular and
extracellular HSPs (eHSPs) trigger a new direction with eHSPs as chemotherapeutic
targets. Herein, the first engineered eHSP nanoinhibitor with high
effectiveness is reported. The zinc–aspartic acid nanofibers
have specific binding ability to eHSP90, which induces a decrease
in the level of the tumor marker-gelatinases, consequently resulting
in downregulation of the tumor-promoting inflammation nuclear factor-kappa
B signaling, and finally inhibiting cancer cell proliferation, migration,
and invasion; while they are harmless to normal cells. Our findings
highlight the potential for cancer treatment by altering the key determinants
that shape its ability to adapt and evolve using novel nanomaterials
The Maize Landcover in 2013 in Northern China
The landcover of maize with a resolution of 30 m in 2013 in the Northern part of China
