Presentation_1_Upper Gastrointestinal Tract IrAEs: A Case Report About Sintilimab-Induced Acute Erosive Hemorrhagic Gastritis.pdf

IntroductionImmune checkpoint inhibitors (ICIs) have now become the standard therapy for malignancies like non-small cell lung cancer and classical Hodgkin’s lymphoma. ICIs are associated with unique immune-related adverse events (irAEs) caused by dysregulated immune activation. Treatment of lower gastrointestinal (GI) tract irAEs, such as colitis, is more common. However, for upper gastrointestinal tract irAEs, there is a lack of consensus in terms of globally standardized disease classification and treatment guidelines. Here, we report a case of sintilimab-induced acute erosive hemorrhagic gastritis.Case PresentationA 54-year-old man with metastatic NSCLC (PT2N2M1 stage IV) underwent treatment with eight courses of sintilimab + bevacizumab, followed by maintenance therapy with sintilimab alone. However, he presented with epigastric pain and melena at the end of the first sintilimab treatment, and the symptoms occurred repeatedly after regular treatment with acute erosive hemorrhagic gastritis. Repeat esophagogastroduodenoscopy (EGD) showed severe hemorrhagic gastritis; symptomatic relief and improvement in EGD images were noted for as long as he was being treated with steroids, methylprednisolone sodium.ConclusionAs far as we are aware, we here describe the first case of sintilimab-associated acute erosive hemorrhagic gastritis, an upper gastrointestinal toxicity event. Throughout the treatment progression, differential diagnosis, multidisciplinary discussion, and the use of immunosuppressants were instrumental in clarifying the diagnosis and were crucial to the prognosis of the patient and continued treatment with ICIs.</p

Additional file 2 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

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Giant Second Harmonic Generation Enhancement in a High‑<i>Q</i> Doubly Resonant Hybrid Plasmon–Fiber Cavity System

A high-quality plasmon–fiber cavity in a doubly resonant configuration can exhibit second-harmonic generation (SHG) with over 5 orders of magnitude enhancement compared to gold nanoparticles on a fused silica substrate. Through coupling to a fiber cavity with the proper diameter, a high-quality (Q ≈ 160) resonance can be achieved in combination with a single gold nanoparticle. In a classical picture, where the incident electric field travels coherently Q times around the fiber during the nonlinear process, the high Q of the coupled mode aids in highly efficient SHG. We accomplish two feats: First, we analyze the Q factor dependence of the SHG efficiency, proving the expected Q4 dependence and thus confirming coherent E-field amplification in the fiber cavity. Second, we carefully adjust the fiber size further and tune the plasmon response of a gold nanoparticle to a high-Q cavity mode. We make sure that the second harmonic wavelength is simultaneously in resonance with a higher order fiber cavity mode, fulfilling the doubly resonant condition. As a result, a giant SH response with conversion efficiency up to 1.6 × 10–5 is detected upon a pump intensity of 5 × 108 W/cm2 for 100 fs pump pulses around 840 nm incident wavelength. Additionally, the importance of the doubly resonant condition is proven by detuning the size of the fiber, which leads to a drastic drop in SHG efficiency. This disparity of the SHG efficiency can be observed even by eye, when monitoring the intensity changes of the visible SH light during detuning

Additional file 7 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

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Additional file 5 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

Additional file 5

Giant Second Harmonic Generation Enhancement in a High‑<i>Q</i> Doubly Resonant Hybrid Plasmon–Fiber Cavity System

A high-quality plasmon–fiber cavity in a doubly resonant configuration can exhibit second-harmonic generation (SHG) with over 5 orders of magnitude enhancement compared to gold nanoparticles on a fused silica substrate. Through coupling to a fiber cavity with the proper diameter, a high-quality (Q ≈ 160) resonance can be achieved in combination with a single gold nanoparticle. In a classical picture, where the incident electric field travels coherently Q times around the fiber during the nonlinear process, the high Q of the coupled mode aids in highly efficient SHG. We accomplish two feats: First, we analyze the Q factor dependence of the SHG efficiency, proving the expected Q4 dependence and thus confirming coherent E-field amplification in the fiber cavity. Second, we carefully adjust the fiber size further and tune the plasmon response of a gold nanoparticle to a high-Q cavity mode. We make sure that the second harmonic wavelength is simultaneously in resonance with a higher order fiber cavity mode, fulfilling the doubly resonant condition. As a result, a giant SH response with conversion efficiency up to 1.6 × 10–5 is detected upon a pump intensity of 5 × 108 W/cm2 for 100 fs pump pulses around 840 nm incident wavelength. Additionally, the importance of the doubly resonant condition is proven by detuning the size of the fiber, which leads to a drastic drop in SHG efficiency. This disparity of the SHG efficiency can be observed even by eye, when monitoring the intensity changes of the visible SH light during detuning

Additional file 4 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

Additional file 4

Additional file 9 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

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Additional file 8 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

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Additional file 1 of CCCH Zinc finger genes in Barley: genome-wide identification, evolution, expression and haplotype analysis

Additional file 1