The outskirts of globular clusters as modified gravity probes

In the context of theories of gravity modified to account for the observed dynamics of galactic systems without the need to invoke the existence of dark matter, a prediction often appears regarding low acceleration systems: wherever $a$ falls below $a_{0}$ one should expect a transition from the classical to the modified gravity regime.This modified gravity regime will be characterised by equilibrium velocities which become independent of distance, and which scale with the fourth root of the total baryonic mass, $V^{4} \propto M$. The two above conditions are the well known flat rotation curves and Tully-Fisher relations of the galactic regime. Recently however, a similar phenomenology has been hinted at, at the outskirts of Galactic globular clusters, precisely in the region where $a<a_{0}$. Radial profiles of the projected velocity dispersion have been observed to stop decreasing along Keplerian expectations, and to level off at constant values beyond the radii where $a<a_{0}$. We have constructed gravitational equilibrium dynamical models for a number of globular clusters for which the above gravitational anomaly has been reported, using a modified Newtonian force law which yields equilibrium velocities equivalent to MOND. We find models can be easily constructed having an inner Newtonian region and an outer modified gravity regime, which reproduce all observational constraints, surface brightness profiles, total masses and line of sight velocity dispersion profiles. Through the use of detailed single stellar population models tuned individually to each of the globular clusters in question, we derive estimates of the total masses for these systems. Interestingly, we find that the asymptotic values of the velocity dispersion profiles are consistent with scaling with the fourth root of the total masses, as expected under modified gravity scenarios.Comment: Accepted in ApJ, 13 pages, 7 figure

Influence of different dynamic sporting disciplines on right ventricular Structure and function in elite male athletes.

Our objective was to assess the influence of different levels of exposure to dynamic training on right ventricular (RV) structure, function and mechanics in elite male athletes. We recruited 492 male elite athletes aged between 18 and 30 years old. Athletes were grouped according to their sporting discipline using the Mitchell Classification as Low Dynamic (LD), Moderate Dynamic (MD) or High Dynamic (HD). All participants underwent 2D, Doppler, tissue Doppler and strain (ε) echocardiography with a focused and comprehensive assessment of the right heart. Athletes involved in MD sports had the largest absolute RV chamber size and when scaled to body size RVOT PLAX, RVOT2, RVD1 and RVD3 were larger in HD compared to MD and LD athletes. There were no between group differences in conventional RV functional indices as well as global RV ε (LD: - 23.4 ± 3.1 vs. MD: - 22.7 ± 2.7 vs. HD: - 23.5 ± 2.6, %) and strain rate (P > 0.01). The base to apex ε gradient in the RV septum was lower in the MD athletes compared to HD and LD due to a lower apical septal ε which significantly correlated with absolute RV chamber size. After scaling for body size there was evidence of larger RV cavities in both MD and HD athletes compared to LD athletes. Global RV function, ε and strain rate were not different between groups. MD athletes had lower apical septal ε that contributed to a smaller base-to-apex ε gradient that is partially associated with larger absolute RV chamber dimensions

Constraints on f(RijklRijkl)f(R_{ijkl}R^{ijkl}) gravity: An evidence against the covariant resolution of the Pioneer anomaly

We consider corrections in the form of $\Delta L(R_{ijkl}R^{ijkl})$ to the Einstein-Hilbert Lagrangian. Then we compute the corrections to the Schwarszchild geometry due to the inclusion of this general term to the Lagrangian. We show that $\Delta L_3=\alpha_{{1/3}}(R_{ijkl}R^{ijkl})^{{1/3}}$ gives rise to a constant anomalous acceleration for objects orbiting the Sun onward the Sun. This leads to the conclusion that $\alpha_{{1/3}}=(13.91\pm 2.11) \times 10^{-26}(\frac{1}{\text{meters}})^{{2/3}}$ would have covariantly resolved the Pioneer anomaly if this value of $\alpha_{{1/3}}$ had not contradicted other observations. We notice that the experimental bounds on $\Delta L_3$ grows stronger in case we examine the deformation of the space-time geometry around objects lighter than the Sun. We therefore use the high precision measurements around the Earth (LAGEOS and LLR) and obtain a very strong constraint on the corrections in the form of $\Delta L(R_{ijkl}R^{ijkl})$ and in particular $\Delta L=\alpha_n(R_{ijkl}R^{ijkl})^n$. This bound requires $\alpha_{{1/3}}\leq6.12\times 10^{-29}(\frac{1}{\text{meters}})^{{2/3}}$. Therefore it refutes the covariant resolution of the Pioneer anomaly.Comment: ...v5: references added, new discussions adde

Selection Of A Novel Aptamer Against Vitronectin Using Capillary Electrophoresis And Next Generation Sequencing

Breast cancer (BC) results in ≃40,000 deaths each year in the United States and even among survivors treatment of the disease may have devastating consequences, including increased risk for heart disease and cognitive impairment resulting from the toxic effects of chemotherapy. Aptamer-mediated drug delivery can contribute to improved treatment outcomes through the selective delivery of chemotherapy to BC cells, provided suitable cancer-specific antigens can be identified. We report here the use of capillary electrophoresis in conjunction with next generation sequencing to develop the first vitronectin (VN) binding aptamer (VBA-01; Kd 405 nmol/l, the first aptamer to vitronectin (VN; Kd = 405 nmol/l), a protein that plays an important role in wound healing and that is present at elevated levels in BC tissue and in the blood of BC patients relative to the corresponding nonmalignant tissues. We used VBA-01 to develop DVBA-01, a dimeric aptamer complex, and conjugated doxorubicin (Dox) to DVBA-01 (7:1 ratio) using pH-sensitive, covalent linkages. Dox conjugation enhanced the thermal stability of the complex (60.2 versus 46.5°C) and did not decrease affinity for the VN target. The resulting DVBA-01-Dox complex displayed increased cytotoxicity to MDA-MB-231 BC cells that were cultured on plasticware coated with VN (1.8 × 10⁻⁶mol/l) relative to uncoated plates (2.4 × 10⁻⁶ mol/l), or plates coated with the related protein fibronectin (2.1 × 10⁻⁶ mol/l). The VBA-01 aptamer was evaluated for binding to human BC tissue using immunohistochemistry and displayed tissue specific binding and apparent association with BC cells. In contrast, a monoclonal antibody that preferentially binds to multimeric VN primarily stained extracellular matrix and vessel walls of BC tissue. Our results indicate a strong potential for using VN-targeting aptamers to improve drug delivery to treat BC

Phenomenological covariant approach to gravity

We covariantly modify the Einstein-Hilbert action such that the modified action perturbatively resolves the flat rotational velocity curve of the spiral galaxies and gives rise to the Tully-Fisher relation, and dynamically generates the cosmological constant. This modification requires introducing just a single new universal parameter.Comment: v6: a mistake in deriving the equation of the cosmological constant corrected, refs adde

A meta-analysis for echocardiographic assessment of right ventricular structure and function in ARVC.

INTRODUCTION: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited pathology that can increase the risk of sudden death. Current Task Force Criteria for echocardiographic diagnosis do not include new, regional assessment tools which may be relevant in a phenotypically diverse disease. We adopted a systematic review and meta-analysis approach to highlight echocardiographic indices that differentiated ARVC patients and healthy controls. METHODS: Data was extracted and analysed from prospective trials that employed a case-control design meeting strict inclusion and exclusion as well as a-priori quality criteria. Structural indices included proximal RV outflow tract(RVOT1) and RV diastolic area(RVDarea). Functional indices included RV fractional area change (RVFAC), Tricuspid Annular Systolic Excursion(TAPSE), peak systolic and early diastolic myocardial velocities (S' and E' respectively) and myocardial strain. RESULTS: Patients with ARVC had larger RVOT1 (mean SD; 34 vs. 28 mm P<0.001) and RVDarea (23 vs. 18 cm2 P<0.001) compared to healthy controls. ARVC patients also had lower RVFAC (38 vs. 46 % P<0.001), TAPSE(17 vs. 23 mm P<0.001), S' (9 vs. 12 cm.s-1 P<0.001), E' (9 vs. 13 cm.s-1 P<0.001) and myocardial strain (-17 vs. -30% P<0.001). CONCLUSION: The data from this meta-analysis support current Task Force criteria for the diagnosis of ARVC. In addition, other RV measures that reflect the complex geometry and function in ARVC clearly differentiated between ARVC and healthy controls and may provide additional diagnostic and management value. We recommend that future working groups consider this data when proposing new / revised criteria for the echocardiographic diagnosis of ARVC

Asymmetric triplex metallohelices with high and selective activity against cancer cells

Small cationic amphiphilic α-helical peptides are emerging as agents for the treatment of cancer and infection, but they are costly and display unfavourable pharmacokinetics. Helical coordination complexes may offer a three-dimensional scaffold for the synthesis of mimetic architectures. However, the high symmetry and modest functionality of current systems offer little scope to tailor the structure to interact with specific biomolecular targets, or to create libraries for phenotypic screens. Here, we report the highly stereoselective asymmetric self-assembly of very stable, functionalized metallohelices. Their anti-parallel head-to-head-to-tail ‘triplex’ strand arrangement creates an amphipathic functional topology akin to that of the active sub-units of, for example, host-defence peptides and ​p53. The metallohelices display high, structure-dependent toxicity to the human colon carcinoma cell-line HCT116 ​p53++, causing dramatic changes in the cell cycle without DNA damage. They have lower toxicity to human breast adenocarcinoma cells (MDA-MB-468) and, most remarkably, they show no significant toxicity to the bacteria methicillin-resistant Staphylococcus aureus and Escherichia coli. At a glanc

A meta-analysis for echocardiographic assessment of right ventricular structure and function in ARVC.

INTRODUCTION: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited pathology that can increase the risk of sudden death. Current Task Force Criteria for echocardiographic diagnosis do not include new, regional assessment tools which may be relevant in a phenotypically diverse disease. We adopted a systematic review and meta-analysis approach to highlight echocardiographic indices that differentiated ARVC patients and healthy controls. METHODS: Data was extracted and analysed from prospective trials that employed a case-control design meeting strict inclusion and exclusion as well as a-priori quality criteria. Structural indices included proximal RV outflow tract(RVOT1) and RV diastolic area(RVDarea). Functional indices included RV fractional area change (RVFAC), Tricuspid Annular Systolic Excursion(TAPSE), peak systolic and early diastolic myocardial velocities (S' and E' respectively) and myocardial strain. RESULTS: Patients with ARVC had larger RVOT1 (mean ? SD; 34 vs. 28 mm P<0.001) and RVDarea (23 vs. 18 cm2 P<0.001) compared to healthy controls. ARVC patients also had lower RVFAC (38 vs. 46 % P<0.001), TAPSE(17 vs. 23 mm P<0.001), S' (9 vs. 12 cm.s-1 P<0.001), E' (9 vs. 13 cm.s-1 P<0.001) and myocardial strain (-17 vs. -30% P<0.001). CONCLUSION: The data from this meta-analysis support current Task Force criteria for the diagnosis of ARVC. In addition, other RV measures that reflect the complex geometry and function in ARVC clearly differentiated between ARVC and healthy controls and may provide additional diagnostic and management value. We recommend that future working groups consider this data when proposing new / revised criteria for the echocardiographic diagnosis of ARVC

Simulation and optimization of tuneable microstrip patch antenna for fifth-generation applications based on graphene

Microstrip patch antennas (MPAs) are known largely for their versatility in terms of feasible geometries, making them applicable in many distinct circumstances. In this paper, a graphene-based tuneable single/array rectangular microstrip patch antenna (MPA) utilizing an inset feed technique designed to function in multiple frequency bands are used in a fifth-generation (5G) wireless communications system. The tuneable antenna is used to eliminate the difficulties caused by the narrow bandwidths typically associated with MPAs. The graphene material has a reconfigurable surface conductivity that can be adjusted to function at the required value, thus allowing the required resonance frequency to be selected. The simulated tuneable antenna comprises a copper radiating patch with four graphene strips used for tuning purposes and is designed to cover a wide frequency band. The proposed antenna can be tuned directly by applying a direct current (DC) voltage to the graphene strips, resulting in a variation in the surface impedance of the graphene strips and leading to shifts in the resonance frequency