Management of bimaxillary protrusion with missing molar using T-loop and couple force

Background: Management of bimaxillary protrusion can be challenging and should be used with maximum anchorage to prevent loss of anchorage and improve the facial profile. In addition, a patient with a missing molar is often found in a dental clinic. Space closure can cause tipping movement rather than bodily, so couple force should be used. Purpose: This case report aims to manage the bimaxillary protrusion with a missing molar using a T-loop and a transpalatal arch (TPA) as maximum anchorage for correction of the facial profile and couple force to create bodily movement for the space closure of a missing first molar. Case: A 21-year-old female patient complained about her protruding teeth. An intraoral examination indicated Angle’s Class I malocclusion on the left molar relation, with the lower-right first molar missing, mild crowding maxilla and mandible, 6 mm of overjet and 5 mm of overbite, and midline shift at the maxilla and mandible. Case Management: The treatment plan was the extraction of teeth 14, 24, 34; alignment with pre-adjusted McLaughlin Bennett Trevisi (MBT) 0.022; retraction of the anterior segment with a T-loop, TPA, and close spacing of the missing first molar with couple force on the buccal and lingual side and tip back. Retention was done with removable retainers. At the end of the treatment, normal incisive inclination and closed space of the missing first molar were achieved, along with an improvement of the facial profile. Conclusion: Bimaxillary protrusion can be successfully treated by means of extraction of the premolar(s), space closure for correction of the profile with T-loop and TPA, and closing the space of the missing molar with couple force on the buccal and lingual sides and tip back

High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate(EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K- without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p<0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K- group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p<0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG

High Mobility Group Box 1 and Heat Shock Protein-70 Expression Post (-)-Epigallocatechin-3-Gallate in East Java Green Tea Methanolic Extract Administration During Orthodontic Tooth Movement in Wistar Rats

Objective: To investigate the expression of High Mobility Group Box 1 (HMGB1) and Heat Shock Protein-70 (HSP-70) during orthodontic tooth movement (OTM) after (-)- Epigallocatechin-3-Gallate (EGCG) in East Java Green Tea (Camelia Sinensis) Methanolic Extract (GTME) administration in vivo. Material and Methods: 28 Wistar rats (Rattus Novergicus) was used and divided into 4 groups accordingly: K- without EGCG and OTM; K+ with OTM, without EGCG for 14 days; T1with OTM for 14 days and EGCG for 7 days; treatment group 2 (T2) with OTM and EGCG for 14 days. OTM animal model was achieved through the installation of the OTM device by means of NiTi close coil spring with 10g force placed between the first incisor and first maxillary molars. The samples were terminated on Day 14. The pre-maxillary was isolated for the immunohistochemical examination. Analysis of Variance (ANOVA) then continued with Tukey Honest Significant Difference (HSD) (p&lt;0.05) was performed to analyze the data. Results: The highest HMGB1 and HSP-70 expression were found in the K+ group pressure&nbsp; side, meanwhile the lowest HMGB1 and HSP-70 expression were found in K- group tension side in the alveolar bone. There was a significant decrease of HMGB1 and HSP-70 expression in T2 compared to T1 and K+ with significant between groups (p&lt;0.05; p=0.0001). Conclusion: The decreased expression of HMGB1 and HSP-70 in alveolar bone of OTM wistar rats due to post administration of GTME that consisted EGCG

Pengaruh Pemberian EGCG (Epigallocatechin-3-Gallate) Terhadap Ekspresi RUNX2 Dan OSTERIX Pada Pergerakan Gigi Ortodonti

Latar Belakang: Remodeling tulang alveolar sangat penting untuk mencapai pergerakan gigi ortodonti (PGO) yang optimal. Ekspresi faktor transkripsi terkait 2 (RUNX2) dan Osterix (OSX) penting untuk remodeling tulang. Epigallocatechin-3-Gallate (EGCG) dari teh hijau (Camelia Sinensis) dapat meningkatkan remodeling tulang. Tujuan : penelitian ini bertujuan untuk mengetahui efek EGCG pada ekspresi OSX dan RUNX2 selama OTM pada tikus Wistar (Rattus Novergicus). Metode: Eksperimen dengan post-test only dan simple random sampling dilakukan. Sampel terdiri dari dua puluh delapan tikus wistar kemudian dibagi menjadi 4 kelompok (n = 7), CN: kelompok kontrol negatif, CP: kelompok kontrol positif dengan OTM tetapi tanpa administrasi EGCG, T1: OTM selama 14 hari dan administrasi EGCG dari hari 7 hingga hari ke 14, T2: OTM dengan administrasi EGCG selama 14 hari. Pegas koil Nickle-Titanium dengan gaya 10 g / mm ditempatkan di antara gigi insisif dan molar maksila. EGCG diisolasi dari ekstrak teh hijau Jawa Timur dengan cara maserasi atau metode refluks kemudian dikonfirmasi dengan alat Thin Layer Chromatography (TLC) Densitometry. Ekspresi RUNX2 dan Osterix dianalisis dengan menggunakan pemeriksaan Imunohistokimia. Semua data dianalisis dengan Analisis Varians (ANOVA) dilanjutkan dengan Least Signficant Difference (LSD) (pSD) (p <0,05). Hasil: EGCG 4,91% berhasil diperoleh melalui metode maserasi. Ekspresi RUNX2 dan OSX tertinggi ditemukan di sisi tarikan kelompok T2 dengan signifikan antar kelompok (p <0,05). Kesimpulan: EGCG dapat meningkatkan ekspresi RUNX2 dan Osterix pada sisi tarikan dan tekanan

Perawatan maloklusi kelas I dengan rotasi caninus 180° dan impaksi premolar rahang atas

Derotasi gigi caninus perlu dikoreksi di fase awal suatu perawatan ortodonti cekat. Walaupun kasus gigi kaninus yang ekstrim merupakan salah satu masalah yang berat untuk ortodontis, tetapi de-rotasi gigi anterior dengan menggunakan powerchain merupakan cara yang sederhana dan efektif. Tujuan studi kasus ini adalah untuk memaparkan koreksi berdesakan anterior dengan rotasi 180º caninus dan impaksi premolar rahang atas. Laki-laki usia 17 tahun dengankeluhan gigi taring rahang atas yang abnormal dan gigi depan yang terasa maju. Pada pemeriksaan ekstraoral menunjukan profil wajah yang cembung dengan bibir yang kompeten. Pada pemeriksaan intraoral menunjukkan relasi kelas I angle dengan berdesakan rahang atas dan bawah. Pada pemeriksaan radiografi menunjukkan adanya impaksi pada gigi premolar kiri atas. Pada pemeriksaan klinis dan sefalometri menunjukkan relasi skeletal kelas I. Gigi 14, 25, 34, dan 44 dicabut untuk koreksi protrusi dan berdesakan. Derotasi rotasi caninus rahang atas dilakukandengan kawat SS 16.22 dan powerchain pada sisi labial dan palatal. Setelah itu, dilakukan retraksi 2 tahap untuk koreksi profil. Kesimpulan dari kasus ini perawatan tidak hanya mencapai faktor estetik namun juga fungisonal yang baik. Pada kasus ini relasi caninus terkoreksi dan profil wajah membaik

Epigallocatechin-3-gallate Green Tea (Camelia Sinensis) Phytomedicine for Orthodontic Tooth Relapse Prevention: Narrative Review

Epigallocatechin-3-gallate (EGCG) is an active compound that is abundant in green tea (Camellia sinensis). EGCG has potential as an antioxidant, anti-inflammatory, anti-osteoclastogenesis as well as pro-angiogenic and pro-osteoblastogenesis. Orthodontic tooth relapse (OTR) may occur due to suboptimal alveolar bone remodeling and excessive inflammation during orthodontic tooth movement (OTM) which causes inhibition of periodontal tissue regeneration. EGCG is thought to increase the regeneration of periodontal tissue after OTM so as to prevent relapse. This narrative literature review aimed to describe the potential of the active compound EGCG in green tea phytomedicine as a candidate biomaterial to prevent OTR. EGCG has strong antioxidant potential by being able to reduce High Mobility Group Box 1 (HMGB-1) and Heat Shock Protein-70 (HSP-70) during inflammation. EGCG in green tea can inhibit pro-inflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) through its antioxidant properties. Osteoclastogenesis can be suppressed by administering EGCG because of the effect of decreasing TNF-α and signaling inhibition of Receptor activator of nuclear factor κ-β (RANK) and Receptor activator of nuclear factor κ-β ligand (RANKL) so that osteoblastogenesis can increase. The increase in osteoblastogenesis after EGCG administration was due to osteoinductive effects such as Bone Morphogenic Protein-2 (BMP-2) activating runt-related transcription factor-2 (RUNX2) and osterix, resulting in osteoblast maturation. Mature osteoblasts secreted bone related proteinfor alveolar bone regeneration such as osteocalcin, osteonectin and osteopontin which can prevent relapse after OTM. EGCG, which is the active compound in green tea (C. sinenis) may potential to be used as phytotherapy for orthodontic tooth relapse