22 research outputs found

    Real-time supervision of industrial waste-water treatment plants applied to the surface treatment industries

    No full text
    International audienceThe project described in this paper consists of two main stages: the development of a dedicated instrument enabling continuous simultaneous measures of industrial pollutants (e.g. metal ions: Ni2+, Cu2+, Zn2+, ...) and the design of a Real-time Expert System (RTES) which would provide better information and decision support so as to improve the supervision of waste-water treatment plants in real-time, applied to the surface treatment (electroplating) industries. The sensor is based on the principle of spectral absorption analysis. The real-time expert system is being developed using a commercial, industrially validated RTES-development software G2™ (by Gensym Corp.). A mixed knowledge-base is being implemented, comprising both types of knowledge: quantitative (e.g. theoretical knowledge issued from chemistry) and qualitative (i.e. operators' 'experience and know-how')

    Introduction

    No full text
    This collection of articles has been constituted with the most total freedom accorded to all those who contributed [...]. We had to choose [...] a name, a particular title. We chose CALIBAN. People will ask why..."And why not?," shall we answer. Renan's shade, we think, will not hold it against us. Moreover, people generally agree that the strange character from The Tempest, only partially understood and still debated, holds a certain interest precisely because of his uncertainties. Let it be..

    Introduction

    No full text
    Le présent recueil d'articles a été constitué dans la liberté la plus complète pour ses participants [...]. Restait à choisir [...] un nom, un titre particulier. Nous avons opté pour celui de CALIBAN. L'on nous demandera pourquoi..."Et pourquoi pas ?" répondrons-nous. L'ombre de Renan, croyons-nous, ne nous en tiendra pas rigueur. Au surplus, on s'accorde pour reconnaître à l'étrange personnage de La Tempête, incomplètement compris et toujours discuté, quelque intérêt en raison même souvent d..

    Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia.

    No full text
    Little is known about inherited factors associated with the risk of developing chronic myelogenous leukemia (CML). We used a dedicated DNA chip containing 16 561 single nucleotide polymorphisms (SNPs) covering 1 916 candidate genes to analyze 437 CML patients and 1 144 healthy control individuals. Single SNP association analysis identified 139 SNPs that passed multiple comparisons (1% false discovery rate). The HDAC9, AVEN, SEMA3C, IKBKB, GSTA3, RIPK1 and FGF2 genes were each represented by three SNPs, the PSM family by four SNPs and the SLC15A1 gene by six. Haplotype analysis showed that certain combinations of rare alleles of these genes increased the risk of developing CML by more than two or three-fold. A classification tree model identified five SNPs belonging to the genes PSMB10, TNFRSF10D, PSMB2, PPARD and CYP26B1, which were associated with CML predisposition. A CML-risk-allele score was created using these five SNPs. This score was accurate for discriminating CML status (AUC: 0.61, 95%CI: 0.58-0.64). Interestingly, the score was associated with age at diagnosis and the average number of risk alleles was significantly higher in younger patients. The risk-allele score showed the same distribution in the general population (HapMap CEU samples) as in our control individuals and was associated with differential gene expression patterns of two genes (VAPA and TDRKH). In conclusion, we describe haplotypes and a genetic score that are significantly associated with a predisposition to develop CML. The SNPs identified will also serve to drive fundamental research on the putative role of these genes in CML development.This work was supported by INSERM (Pharmacogenetic-REPAC Network), by the Grant U03S03 from the ECOS-Sud program (France-Uruguay), a Grant from the Association Jean Bernard, France and a grant from the French Ministry of Health (Programme Hospitalier de Recherche Clinique (PHRC 2011, 11N28), SPIRIT ClinicalTrials.gov Identifier: NCT00219739
    corecore