Visualization 2_LMA-GIMF-SMF S1_2.mp4

Characterization of LMA-GIMF-SMF with the high energy of fundamental mode in LMA

Visualization 6_LMA-GIMF-SMF with 7.5um offset_6.mp4

Characterization of LMA-GIMF-SMF with 7.5 um offse

Visualization 4_LMA-GIMF-SMF with 2.5um offset_4.mp4

Characterization of LMA-GIMF-SMF with 2.5 um offse

Visualization 5_LMA-GIMF-SMF with 5um offset_5.mp4

Characterization of LMA-GIMF-SMF with 5 um offse

Visualization 1_SMF-GIMF-SMF_1.mp4

Characterization of SMF-GIMF-SM

Visualization 3_LMA-GIMF-SMF S2_3.mp4

Characterization of LMA-GIMF-SMF with the low energy of fundamental mode in LMA

Data_Sheet_1_v1_Might female patients benefit more from bariatric surgery with respect to inflammation.pdf

BackgroundBariatric surgery is an effective method for severe obesity and its related comorbidities, in which inflammation plays a crucial role. The aim of this study was to investigate the changes of Neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) in patients undergoing laparoscopic sleeve gastrectomy (LSG) and to explore the related factors including gender.MethodsWe retrospectively included 72 patients undergoing LSG in our hospital from 2017 to 2020. Clinical information, laboratory investigations as well as parameters derived from traditional and 2D strain echocardiography were collected. Univariate logistic model was used in myocardial performance index (MPI) and E/E′ analysis. Univariate and Multivariate logistic model were used in NLR analysis.ResultsAt baseline, all patients had normal left ventricular ejection fraction (LVEF). The myocardial performance index (MPI) (OR = 1.218 (95%CI 1.040, 1.426); p = 0.0142) and E/E′ (OR = 1.364 (95%CI 1.124, 1.655); p = 0.0017) were independently associated with CRP. LSG led to a significant decrease in inflammatory markers (NLR, 2.4 ± 1.59 vs.1.7 ± 0.86; CRP, 5.6 ± 3.17 vs. 2.1 ± 2.35 mg/L, respectively, both p ConclusionsThe present study indicated a significant correlation between subclinical cardiac dysfunction and CRP among obese patients. Furthermore, female patients might benefit more from bariatric surgery on inflammation.</p

Amino(oligo)thiophene-Based Environmentally Sensitive Biomembrane Chromophores

There is a growing need for cellular imaging with fluorescent probes that emit at longer wavelengths to minimize the effects of absorption, autofluorescence, and scattering from biological tissue. In this paper a series of new environmentally sensitive hemicyanine dyes featuring amino(oligo)thiophene donors have been synthesized via aldol condensation between a 4-methylpyridinium salt and various amino(oligo)thiophene carboxaldehydes, which were, in turn, obtained from amination of bromo(oligo)thiophene carboxaldehyde. Side chains on these fluorophores impart a strong affinity for biological membranes. Compared with benzene analogues, these thiophene fluorophores show significant red shift in the absorption and emission spectra, offering compact red and near-infrared emitting fluorophores. More importantly, both the fluorescence quantum yields and the emission peaks are very sensitive to various environmental factors such as solvent polarity or viscosity, membrane potential, and membrane composition. These chromophores also exhibit strong nonlinear optical properties, including two-photon fluorescence and second harmonic generation, which are themselves environmentally sensitive. The combination of long wavelength fluorescence and nonlinear optical properties make these chromophores very suitable for applications that require sensing or imaging deep inside tissues

Unique Contrast Patterns from Resonance-Enhanced Chiral SHG of Cell Membranes

Chirality can produce novel nonlinear optical effects that may form the basis for new imaging contrast agents. In this paper, we developed a new chiral chromophore 2, which is the dimer of a known voltage sensitive dye, monomer 1, with the chirality originating from the twisted orientation between two subunits. Racemic dimer and monomer 1 were used as the references to study the effect of chirality in SHG microscopy of live cells. All these dyes selectively stain the outer leaflets of cell membranes, producing strong resonance-enhanced SHG images. At the symmetric junction between two adherent cells, monomer or racemic dimer SHG is forbidden due to centrosymmetry, and indeed little SHG was observed (10 ± 1% relative to nonjunction). When stained with the chiral dimer, the junction is no longer centrosymmetric and much stronger SHG was observed (39 ± 4% relative to nonjunction). Plane polarized light produces highly polarized images of spherical cells stained with racemic dye, but for the chiral dye, the polarized pattern is largely eliminated by the chiral SHG emanating from the subresolution membrane convolutions

A concise guide to scheduling with learning and deteriorating effects

In practical manufacturing systems, the job processing time usually varies with the performance change of manufacturing resources, among which the learning and deteriorating effects are typical characteristics. Due to the interests from both academic exploration and industrial innovation, the research on scheduling problems with these effects is abundant and diverse. However, some studied problems need to be strengthened in combination with realistic production scenarios. This paper provides a concise guide to scheduling problems with these effects, giving a comprehensive review and critical hints for future research. A novel classification scheme is designed based on four levels of different domains, i.e. effects, processing ways, processing time functions, and manufacturing environments. Based on this scheme, the scheduling problems are first distinguished into three categories: learning effects, deteriorating effects, and combined effects. In each category, models are then refined along three lines: general processing way, batch scheduling, and group scheduling. Combined with the attributes of actual processing time functions and manufacturing environments, the evolvement of related scheduling models and a critical analysis on the proposed algorithms are well analysed. Afterwards, the research gaps are revealed and the research directions are indicated from the perspectives of practical applications, time functions, and designed algorithms.</p