Educational profession-oriented propaedeutic Russian language course as a basis of coming of international students of pre-university training stage into the educational medium of the higher medical institution

Цель статьи - рассмотреть некоторые способы и методы (фреймовый подход) формирования лингвокультурологической медицинской компетенции иностранных учащихся предвузовского этапа на занятиях по русскому языку общелитературного стиля в соответствии со спецификой их будущего обучения в русскоязычной среде медицинского вуза. Актуальность исследования заключается в том, что учебный пропедевтический курс русского языка, ориентированный на изучение иностранными учащимися языка медицинской науки, является важнейшим и необходимым условием для их обучения в медицинском университете. Преподавание основывается на использовании общедидактических и методических принципов начального обучения русскому языку будущих студентов- медиков, которые способствуют дальнейшему усвоению и совершенствованию учебно- профессиональных знаний в условиях русской языковой среды медицинского вуза. В процессе исследования были использованы следующие методы: теоретический и практический анализ научной литературы по методике преподавания иностранного языка и русского как иностранного, аудиовизуальное наблюдение, беседы с иностранными студентами, пробное обучение. Результаты. В процессе изучения русского языка иностранные учащиеся приобретают новые знания, расширяется их эрудиция, кругозор. Иностранные учащиеся предвузовского этапа входят в мир языка медицинской науки, знакомясь с элементами её лингвистической, коммуникативной и культурологической базы. Выводы: пропедевтический курс русского языка закладывает основы знаний о специфике изучения медицины на русском языке, которые помогут иностранным учащимся предвузовского этапа подготовки спустя год войти в образовательную среду медицинского университета.The aim of the research is to consider some ways and methods (frame approach) of forming lingual- cultural medical competence of international students of pre-University training stage at the Russian Language classes in accordance with the specifics of their future learning in Russian-speaking medium of higher medical institution. Relevance of the study lies in the fact that educational propaedeutic course of the Russian Language, focused on training foreign students the language of medical science, is the most important and necessary condition for their studying in the medical university. Training is based on the usage of general didactic and methodical principles of elementary level of teaching Russian the future medical students, which promoting further learning and mastering the educational-professional knowledge in the conditions of Russian speaking environment of higher medical institution. The author has used the following methods: theoretical and practical analysis of scientific literature on methods of teaching foreign language and Russian as a foreign language, audio-visual monitoring, interviews with foreign students, experimental teaching. Results. When learning Russian the international students get knowledge, enlarge their erudition, the outlook. International students of pre-University training stage come into the world of the Language of medical science, becoming acquainted with the elements of its linguistic, communicative and cultural base. Conclusion. The propaedeutic course of Russian lays foundations of knowledge of specifics of learning medicine in Russian, which will help international students of pre-university training stage to be admitted to the educational environment of medical University after the first year of studying

Electron shuttle-mediated microbial Fe(III) reduction under alkaline conditions

Purpose: Extracellular Fe(III) reduction plays an important role in a variety of biogeochemical processes. Several mechanisms for microbial Fe(III) reduction in pH-neutral environments have been proposed, but pathways of microbial Fe(III) reduction within alkaline conditions have not been clearly identified. Alkaline soils are vastly distributed; thus, a better understanding of microbial Fe(III) reduction under alkaline conditions is of significance. The purpose of this study is to explore the dominant mechanism of bacterial iron reduction in alkaline environments. Materials and methods: We used antraquinone-2,6-disulfonate (AQDS) as a representative of quinone moities of humic substances and elemental sulfur and sulfate as sulfur species to investigate the potential role of humic substances and sulfur species in mediating microbial Fe(III) reduction in alkaline environments. We carried out thermodynamic calculations to predict the ability of bacteria to reduce Fe(III) (oxyhydr)oxides under alkaline conditions and the ability of AQDS and sulfur species to serve as electron acceptors for microbial anaerobic respiration in an assumed alkaline soil environments. A series of incubation experiments with two model dissimilatory metal reducing bacteria, Shewanella oneidensis MR-1 and Geobacter sulfurreducens PCA as well as mixed bacteria enriched from a soil were performed to confirm the contribution of AQDS and sulfur species to Fe(III) reduction under alkaline conditions. Results and discussion: Based on thermodynamic calculations, we predicted that, under alkaline conditions, the enzymatic reduction of Fe(III) (oxyhydr)oxides would be thermodynamically feasible but very weak. In our incubation experiments, the reduction of ferrihydrite by anaerobic cultures of Shewanella oneidensis MR-1, Geobacter sulfurreducens PCA or microbes enriched from a soil was significantly increased in the presence of S0 or AQDS. Notably, AQDS contributed more to promoting Fe(III) reduction as a soluble electron shuttle than S0 did under the alkaline conditions probably because of different mechanisms of microbial utilization of AQDS and S0. Conclusions: These results suggest that microbial reduction of Fe(III) (oxyhydr)oxides under alkaline conditions may proceed via a pathway mediated by electron shuttles such as AQDS and S0. Considering the high ability of electron shuttling and vast distribution of humic substances, we suggest that humic substance-mediated Fe(III) reduction may potentially be the dominant mechanism for Fe(III) reduction in alkaline environments

Исследование реологических свойств растворов ксантановой смолы и крахмала для оценки межмолекулярного взаимодействия данных реагентов в биополимерных буровых растворах

Работа направленна на разработку систем биополимерных растворов для бурения горизонтальных участков скважин с повышенной эффективностью очистки ствола.The work is aimed to develope systems of biopolymer drilling fluids for horizontal drilling with increased efficiency of wellbore cleaning

Lack of influence of the COX inhibitors metamizol and diclofenac on platelet GPIIb/IIIa and P-selectin expression in vitro

BACKGROUND: The effect of non-steroidal anti-inflammatory drugs (NSAIDs) for reduced platelet aggregation and thromboxane A(2 )synthesis has been well documented. However, the influence on platelet function is not fully explained. Aim of this study was to examine the influence of the COX-1 inhibiting NSAIDs, diclofenac and metamizol on platelet activation and leukocyte-platelet complexes, in vitro. Surface expression of GPIIb/IIIa and P-selectin on platelets, and the percentage of platelet-leukocyte complexes were investigated. METHODS: Whole blood was incubated with three different concentrations of diclofenac and metamizol for 5 and 30 minutes, followed by activation with TRAP-6 and ADP. Rates of GPIIb/IIIa and P-selectin expression, and the percentage of platelet-leukocyte complexes were analyzed by a flow-cytometric assay. RESULTS: There were no significant differences in the expression of GPIIb/IIIa and P-selectin, and in the formation of platelet-leukocyte complexes after activation with ADP and TRAP-6, regarding both the time of incubation and the concentrations of diclofenac and metamizol. CONCLUSIONS: Accordingly, the inhibitory effect of diclofenac and metamizol on platelet aggregation is not related to a reduced surface expression of P-selectin and GPIIb/IIIa on platelets