Amidosilylcyclopentadienyl monoalkyl zirconium compounds: evidence\ud of a N-assisted 1,3-proton shift olefin isomerization mechanism

New η5-cyclopentadienyl-η1-amido monoalkyl zirconium compounds of the type [ZrR(η5-\ud C5H4SiMe2-η1-NtBu)(η5-C5H4R0)] (R = Me, Bn; R0 =H, SiMe3, SiMe2CH2CHdCH2) have been\ud synthesized and fully characterized. Allyldimethylsilylcyclopentadienyl derivatives [ZrR(η5-C5H4SiMe2-η1-NtBu)(η5-C5H4SiMe2CH2CHdCH2)] isomerize the allyl fragment bound to the\ud cyclopentadienyl ring to give the corresponding [ZrR(η5-C5H4SiMe2-η1-NtBu)(η5-C5H4SiMe2CHdCHCH3)] compounds (R=Me, Bn). Experimental as well as DFT computational studies support an isomerization mechanism based on a N-assisted 1,3-proton shift

PHYSIOLOGICAL AND GROWTH RESPONSE OF TOMATO PLANTS AFTER TRICHODERMA SPP. SEED TREATMENTS

Different isolates of Trichoderma are able to produce metabolites which induce some morphological and physiological changes in plant such as enhanced plant growth and response to plant pathogens or reduced plant stress. The aim of the present study is to evaluate the effect of some Trichoderma isolates on plant growth promoting and physiological parameters of tomato plants. Also, the Trichoderma isolates were assessed based on IAA (indole 3-acetic acid) production and ability to solubilize phosphate, traits associated to growth. Tomato seed treatment with Trichoderma isolates led to a significant increase in plant height as well as root length and root fresh/ dry weight. However, metabolite production varied among isolates and depends on the isolate. Our data indicated that three of the Trichoderma isolates studied increase leaf pigments content and improve the photosynthetic activity of tomato plants

Complejos amidosililciclopentadienilo de titanio y circonio con un anillo ciclopentadienilo mono- y di- sustituido. Catalizadores en procesos de isomerización de olefinas y formación de enlaces Si-C y Si-Si

Texto en español y resumen en inglésSe han preparado y caracterizado nuevos complejos cloro amidosililciclopentadienilo de titanio y circonio con un ligando ciclopentadienilo mono-sustituido [M([eta]5-C5H4SiMe2-?NtBu)([eta]5-C5H4R)Cl] (R = H, M = Zr (7); R = SiMe3, M = Ti (8), M = Zr (9); R = SiMe2CH2CH=CH2, M = Ti (10), M = Zr (11)) y los complejos cloro amidosililciclopentadienilo de circonio con un ligando ciclopentadienilo di-sustituido [Zr([eta]5-C5H4SiMe2-?NtBu){[eta]5-C5H3-1-SiMe2R-3-SiMe3}Cl] (R = cis-+trans-CH=CHCH3 (17), R = CH2CH=CH2 (18)). También se han preparado y caracterizado los complejos hidruro de circonio [Zr(?5-C5H4SiMe2-?NtBu)(?5-C5H4R)H] (R = H (19), R = SiMe3 (20)) y el zirconaciclo [Zr([eta]5-C5H4SiMe2-?NtBu)([eta]5-C5H4SiMe2CH2CH2-[eta]1-CH2)] (21), a partir de la reacción de los correspondientes derivados cloro con NaHBEt3. En la reacción de preparación del complejo 21 se ha detectado la formación de los derivados hidruro [Zr([eta]5-C5H4SiMe2-?NtBu)([eta]5-C5H4SiMe2CH2CH=CH2)H] (22) y [Zr([eta]5-C5H4SiMe2-?NtBu){[eta]5-C5H4SiMe2(trans-CH=CHCH3)}H] (23) como especies intermedias del proceso. Además, se han sintetizado y caracterizado los complejos alquilo de titanio y circonio con un ligando ciclopentadienilo mono-sustituido [M([eta]5-C5H4SiMe2-?NtBu)([eta]5-C5H4R)X] (X = CH3, R = H, M = Ti (27), M = Zr (28); R = SiMe3, M = Ti (29), M = Zr (30); R = SiMe2CH2CH=CH2, M = Ti (31), M = Zr (32); X = Bn, R = SiMe2CH2CH=CH2, M = Zr (33)) y los complejos metilo amidosililciclopentadienilo de circonio con un ligando ciclopentadienilo di-sustituido [Zr([eta]5-C5H4SiMe2-?NtBu){[eta]5-C5H3-1-SiMe2R-3-SiMe3}Cl] (R = cis-+trans-CH=CHCH3 (35), R = CH2CH=CH2 (36)). El tratamiento de disoluciones en C6D6 de los complejos alquilo 32 y 33 a 120 ºC conduce a la formación de los nuevos compuestos [Zr([eta]5-C5H4SiMe2-?NtBu){[eta]5-C5H4SiMe2(trans-CH=CHCH3)}X] (X = Me (37), Bn (38)) con el fragmento alilo isomerizado. El mecanismo del proceso se ha estudiado mediante cálculos teóricos y experimentos de marcaje isotópico. Los complejos cloro 11 y 18 evolucionan en CDCl3 a 140 ºC hacia la formación de los derivados Zr([eta]5-C5H4SiMe2NXtBu)([eta]5-C5H4SiMe2CH2CH=CH2)Cl2] (41) y [Zr([eta]5-C5H4SiMe2NXtBu){[eta]5-C5H3-1-SiMe2(CH2CH=CH2)-3-SiMe3}Cl2] (42). Los complejos hidruro 19 y 20 y el zirconaciclo 21 se han utilizado como catalizadores en la isomerización de olefinas. El derivado hidruro 19 y los complejos metilo 27 y 28 se han empleado como catalizadores de deshidropolimerización del fenilsilano. El derivado hidruro 19 y los complejos metilo 27-29 y dimetilo 34 y 43 han sido probados como catalizadores en la hidrosililación de olefinas. Los complejos alquilo 32 y 33 y del derivado cloro 11 se han estudiado en procesos de hidrosililación intramolecular

Influence Of Soil Type On Yield And Quality Of Different Apple Cultivars

The objective of this study was to determine influence of different soil type on apple yield and quality. To investigate the variation in fruit quality, apples were harvested at commercial maturity on two different soil type. The investigations was conducted in experimental apple orchards located in Focsani region on two different soil type: luvic  brown typical and  luvic brown pseudogleizate. Fruits of Jonathan and Golden Delicios cultivars were tested for color, soluble solids content, total acidity, ascorbic acid, anthocyanins content and chlorophyls content with specific analytrical methods. At harvest yield, dry matter, soluble solids content, ascorbic acid and acidity were affected by soil type. In this study, no significant soil effect was found on color, anthocyanins and chlorophyll fruit content. The results obtained in this study suggest that luvic brown pseudogleizate soil leading to increased yields and enhanced fruit quality

VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia

Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], p=0.0866. Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia

Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)