The Use of 2-Bornanethiol for the Asymmetric Synthesis of Amines

The proposal to synthesize a camphor sulfinamide reagent using 2-bornanethiol was initiated. A novel disulfide for the synthesis of the reagent was produced through inexpensive means via three synthetic steps. Readily available (+)-camphor underwent thionation using phosphorous pentasulfide in excess. The resulting thiocamphor was reduced to camphor thiol (or 2-bornanethiol) and oxidized to yield camphor disulfide. Further investigation of the disulfide is necessary for confirmation and characterization. Oxidation followed by reaction of the purified sample of this product with ammonia and lithium amide could give camphor sulfinamide. It was determined that purification at the end of each step would help to give better results and cleaner NMR spectra to analyze. Limitations included difficulty with keeping reactions under dry conditions as well as large amounts of time required to run each reaction. From here, the purified disulfide will be used to synthesize camphor sulfinamide which could then be combined with chiral aldehydes and ketones to yield imines in high selectivity

The order of prenominal adjectivals in unambiguous unbroken strings in English

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Florianópolis, 1980

A ASSISTÊNCIA SOCIAL E SEUS USUÁRIOS: UMA ANÁLISE DOS BENEFICIÁRIOS DO CARTÃO-ALIMENTAÇÃO EM MARINGÁ/PR

Resumo O presente artigo é resultado estudos investigativos concluídos na cidade de Maringá/PR e tem por objetivo compreender a visão dos usuários do CRAS Ney Braga acerca da assistência social enquanto direito social. Para tanto, entre os meses de abril e junho de 2015 foram entrevistados usuários beneficiários do cartão-alimentação (benefício eventual do município lócus da pesquisa). Em linhas gerais, pode-se dizer que, mesmo após 27 anos dos artigos 203 e 204 da Constituição Federal e sua consequente entrada no campo da Seguridade Social, a percepção da política de assistência social enquanto direito ainda não está alicerçada na compreensão dos entrevistados. Tal constatação deve repercutir nos reais avanços e inúmeros desafios que a política ainda possui nos dias atuais

Traditional Medicine in the Gambia

The practice of traditional medicine is an important aspect of Gambian life and culture. It has existed in the country since before the arrival of western medicine and even the Islamic religion. Although there have been some additions to the methods of traditional healers of The Gambia since the coming of Islam, many of the values and concepts remain as they were when traditional medicine began. Modern medicine, that is the diagnosis and treatment of patients using scientific study and clinical trials, is the predominant form of healthcare for citizens of the United States while in The Gambia, seeking medical attention from traditional healers still remains to be a popular means of treatment. The popularity of traditional medicine continues to climb in the country, which in some ways can be attributed to the president, Alhagi Dr. Yahya A.J.J. Jammeh, who claims to be working to acquire cures of devastating diseases using traditional medicine. Initially, I was interested in following the topic of traditional medicine mostly because I found the idea of using plants as medicine intriguing. The use of medicinal plants is also an attractive subject with the current increasing appeal of herbal remedies and medicines in the United States. Keeping this fact in mind, I wanted to investigate the role herbal remedies played in a culture much different from that of the United States. Being a chemistry student without much prior knowledge about traditional medicine in The Gambia, I was under the impression that I might find many herbalists eager to reveal all of the herbs they used, what sicknesses the herbs treated, and what chemical compounds made these herbs. Upon learning more, I recognized that this was not always going to be the case. My purposes for research evolved into much more modest goals: to establish an understanding of the traditional form of healthcare in The Gambia, the measures being taken to integrate traditional medicine into the modern healthcare system, and the reasons for the effectiveness of herbal medicines. As well as being a way in which people attempt to remain healthy, traditional medicine is also a large piece of the culture that represents The Gambia. Traditional medicine remains within the culture by way of the practitioners from one generation passing the knowledge to members of the next generation. In this way, the title of traditional healer can remain within a family for many generations. The continuation of the knowledge of a traditional healer being put into practice is dependent upon the traditional healer himself. By taking a close look at the work of traditional healers in many areas of The Gambia, I was able to come into contact with a part of the country’s culture

Categorization of Orthologous Gene Clusters in 92 Ascomycota Genomes Reveals Functions Important for Phytopathogenicity

Phytopathogenic Ascomycota are responsible for substantial economic losses each year, destroying valuable crops. The present study aims to provide new insights into phytopathogenicity in Ascomycota from a comparative genomic perspective. This has been achieved by categorizing orthologous gene groups (orthogroups) from 68 phytopathogenic and 24 non-phytopathogenic Ascomycota genomes into three classes: Core, (pathogen or non-pathogen) group-specific, and genome-specific accessory orthogroups. We found that (i) ~20% orthogroups are group-specific and accessory in the 92 Ascomycota genomes, (ii) phytopathogenicity is not phylogenetically determined, (iii) group-specific orthogroups have more enriched functional terms than accessory orthogroups and this trend is particularly evident in phytopathogenic fungi, (iv) secreted proteins with signal peptides and horizontal gene transfers (HGTs) are the two functional terms that show the highest occurrence and significance in group-specific orthogroups, (v) a number of other functional terms are also identified to have higher significance and occurrence in group-specific orthogroups. Overall, our comparative genomics analysis determined positive enrichment existing between orthogroup classes and revealed a prediction of what genomic characteristics make an Ascomycete phytopathogenic. We conclude that genes shared by multiple phytopathogenic genomes are more important for phytopathogenicity than those that are unique in each genome

Ecology of the Mayan Cichlid, Cichlasoma urophthalmus Günther, in the Alvarado Lagoonal System, Veracruz, Mexico

The Mayan cichlid, Cichlasoma urophthalmus, has a wide distribution in southeastern Mexico where it inhabits rivers and coastal lagoons. In the Alvarado lagoonal system, Veracruz, it is distributed towards the north in Camaronera Lagoon. The Mayan cichlid shows an affinity for oligohaline to mesohaline sites with submerged vegetation, well-oxygenated, deep, and transparent water. The major abundance and biomass of this species was obtained during December to February. The diet of Mayan cichlids consists principally of plant detrital material and algae. Length-frequency distribution shows 2 size classes during both the dry and rainy seasons, corresponding to reproductive fish and young of the year; during the nortes season there is only one modal size class of fish between 60–100 mm SL. Individuals with developed gonads are found throughout the year, although most reproductive adults are found between April and December. The highest Gonadosomatic Index (GSI) values coincided with the peak in reproductive activity between May and July. The fecundity ranged from 1,556–3,348 eggs/female, and there was no relationship between female size and fecundity

Bifenthrin Baseline Susceptibility and Evaluation of Simulated Aerial Applications in \u3ci\u3eStriacosta albicosta\u3c/i\u3e (Lepidoptera: Noctuidae)

Striacosta albicosta (Smith) is a maize pest that has recently expanded its geographical range into the eastern United States and southeastern Canada. Aerial application of pyrethroids, such as bifenthrin, has been a major practice adopted to manage this pest. Reports of field failure of pyrethroids have increased since 2013. Striacosta albicosta populations were collected in 2016 and 2017 from maize fields in Nebraska, Kansas, and Canada and screened with bifenthrin active ingredient in larval contact dose-response bioassays. Resistance ratios estimated were generally low in 2016 (1.04- to 1.32-fold) with the highest LC50 in North Platte, NE (66.10 ng/cm2) and lowest in Scottsbluff, NE (50.10 ng/cm2). In 2017, O’Neill, NE showed the highest LC50 (100.66 ng/cm2) and Delhi, Canada exhibited the lowest (6.33 ng/cm2), resulting in a resistance ratio variation of 6.02- to 15.90-fold. Implications of bifenthrin resistance levels were further investigated by aerial application simulations. Experiments were conducted with a spray chamber where representative S. albicosta populations were exposed to labeled rates of a commercial bifenthrin formulation. Experiments resulted in 100% mortality for all populations, instars, insecticide rates, and carrier volumes, suggesting that levels of resistance estimated for bifenthrin active ingredient did not seem to impact the efficacy of the correspondent commercial product under controlled conditions. Results obtained from this research indicate that control failures reported in Nebraska could be associated with factors other than insecticide resistance, such as issues with the application technique, environmental conditions during and/or after application, or the insect’s natural behavior. Data generated will assist future S. albicosta resistance management programs

Dietary nitrate-induced increases in human muscle power: High versus low responders

Maximal neuromuscular power is an important determinant of athletic performance and also quality of life, independence, and perhaps even mortality in patient populations. We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. The present investigation was designed to identify factors contributing to this interindividual variability. Healthy men (n = 13) and women (n = 7) 22-79 year of age and weighing 52.1-114.9 kg were studied using a randomized, double-blind, placebo-controlled, crossover design. Subjects were tested 2 h after ingesting beetroot juice (BRJ) either containing or devoid of 12.3 ± 0.8 mmol of NO3- . Plasma NO3- and nitrite (NO2- ) were measured as indicators of NO bioavailability and maximal knee extensor speed (Vmax ), power (Pmax ), and fatigability were determined via isokinetic dynamometry. On average, dietary NO3- increased (P < 0.05) Pmax by 4.4 ± 8.1%. Individual changes, however, ranged from -9.6 to +26.8%. This interindividual variability was not significantly correlated with age, body mass (inverse of NO3- dose per kg), body mass index (surrogate for body composition) or placebo trial Vmax or fatigue index (in vivo indicators of muscle fiber type distribution). In contrast, the relative increase in Pmax was significantly correlated (r = 0.60; P < 0.01) with the relative increase in plasma NO2- concentration. In multivariable analysis female sex also tended (P = 0.08) to be associated with a greater increase in Pmax. We conclude that the magnitude of the dietary NO3- -induced increase in muscle power is dependent upon the magnitude of the resulting increase in plasma NO2- and possibly female sex

Tier 1 Intervention: Classroom Management

Conclusion Classroom management is an important skill for effective teachers; it is linked to a decrease in teacher burnout and an increase in teacher self-efficacy and improved academic outcomes for students. Teachers, regardless of grade taught or geographic area, report the need for better training in classroom management skills. There are a huge number of potential specific skills and activities which may represent effective classroom management, although these may be clustered into several useful groups. There is also a huge array of literature describing classroom management skills, and many of these have demonstrated effectiveness in research studies

Structure, Atomistic Simulations, and Phase Transition of Stoichiometric Yeelimite

ABSTRACT: Yeelimite, Ca4[Al6O12]SO4, is outstanding as an aluminate sodalite, being the framework of these type of materials flexible and dependent on ion sizes and anion ordering/disordering. On the other hand, yeelimite is also important from an applied perspective as it is the most important phase in calcium sulfoaluminate cements. However, its crystal structure is not well studied. Here, we characterize the room temperature crystal structure of stoichiometric yeelimite through joint Rietveld refinement using neutron and Xray powder diffraction data coupled with chemical soft-constraints. Our structural study shows that yeelimite has a lower symmetry than that of the previously reported tetragonal system, which we establish to likely be the acentric orthorhombic space group Pcc2, with a √2a × √2a × a superstructure based on the cubic sodalite structure. Final unit cell values were a = 13.0356(7) Å, b = 13.0350(7) Å, and c = 9.1677(2) Å. We determine several structures using density functional theory calculations, with the lowest energy structure being Pcc2 in agreement with our experimental result. Yeelimite undergoes a reversible phase transition to a higher-symmetry phase which has been characterized to occur at 470 °C by thermodiffractometry. The higher-symmetry phase is likely cubic or pseudocubic possessing an incommensurate superstructure, as suggested by our theoretical calculations which show a phase transition from an orthorhombic to a tetragonal structure. Our theoretical study also predicts a pressure-induced phase transition to a cubic structure of space group I43m. Finally, we show that our reported crystal structure of yeelimite enables better mineralogical phase analysis of commercial calcium sulfoaluminate cements, as shown by RF values for this phase, 6.9% and 4.8% for the previously published orthorhombic structure and for the one reported in this study, respectively.Universidad de Málaga. Campus de Excelencia Internacional. Andalucía Tech