Two-brane system in a vacuum bulk with a single equation of state

We study the cosmology of a two-brane model in a five-dimensional spacetime, where the extra spatial coordinate is compactifed on an orbifold. Additionally, we consider the existence on each brane of matter fields that evolve in time. Solving the Einstein equations in a vacuum bulk, we can show how the matter fields in both branes are connected and they do not evolve independentlyComment: This work was presented at the IX Taller de la Division de Gravitacion y Fisica Matematica, Colima 201

Cosmological constraints for a two brane-world system with single equation of state

We present the study of two 3-brane system embedded in a 5-dimensional space-time in which the fifth dimension is compactified on a $S^{1}/Z_{2}$ orbifold. Assuming isotropic, homogeneous, and static branes, it can be shown that the dynamics of one brane is dominated by the other one when the metric coefficients have a particular form. We study the resulting cosmologies when one brane is dominated by a given single-fluid component.Comment: This work was presented at the VIII Taller of the DGFM, Tuxtla Gutierrez, Chiapas, Mexico noviembre 22-26, 201

ADSORPTION ESSAYS OF PALLADIUM IN MODIFIED SILICA GEL WITH THIOURONIUM GROUPS: EXPERIMENTAL AND THEORICAL STUDIES

Indexación: Web of Science; ScieloThe silylant 3-cloropropyltriethoxysilyl was anchored over silica gel in anhydrous conditions in order to react with thiourea to obtain modified silica gel with thiouronium. The aim to obtain an inorganic support that is able to hijack metals from the VIII group such as palladium. The product was characterized by Sbet and FTIR infrared spectroscopy. For the determination of the structure in the modified silica gel NMR spectra of silicon and carbon were preformed in solid state. The coordination form of the modified silica gel to the metal was studied computationally in the context of the DFT theory, using the ADF code. This was a collaborative work with "Fundación Chile" for the recuperation of precious metals from the mining industry.http://ref.scielo.org/gk7rm

Fluoxetine: a case history of its discovery and preclinical development

Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS. Advances in drug discovery have widened the therapeutic options with the synthesis of so-called selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine. Areas covered: The aim of this case history is to describe and discuss the pharmacokinetic and pharmacodynamic profiles of fluoxetine, including its acute effects and the adaptive changes induced after long-term treatment. Furthermore, the authors review the effect of fluoxetine on neuroplasticity and adult neurogenesis. In addition, the article summarises the preclinical behavioural data available on fluoxetine’s effects on depressive-like behaviour, anxiety and cognition as well as its effects on other diseases. Finally, the article describes the seminal studies validating the antidepressant effects of fluoxetine. Expert opinion: Fluoxetine is the first selective SSRI that has a recognised clinical efficacy and safety profile. Since its discovery, other molecules that mimic its mechanism of action have been developed, commencing a new age in the treatment of depression. Fluoxetine has also demonstrated utility in the treatment of other disorders for which its prescription has now been approved

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior

Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when associated with an intermolecular interaction, this yields linear polymers of hyperstable serpin molecules, which accumulate at the site of synthesis. This is the basis of many pathologies termed the serpinopathies. We have previously identified a monoclonal antibody (mAb4B12) that, in single-chain form, blocks α1-Antitrypsin (α1-AT) polymerisation in cells. Here, we describe the structural basis for this activity. The mAb4B12 epitope was found to encompass residues Glu32, Glu39 and His43 on helix A and Leu306 on helix I. This is not a region typically associated with the serpin mechanism of conformational change, and correspondingly the epitope was present in all tested structural forms of the protein. Antibody binding rendered β-sheet A - on the opposite face of the molecule - more liable to adopt an 'open' state, mediated by changes distal to the breach region and proximal to helix F. The allosteric propagation of induced changes through the molecule was evidenced by an increased rate of peptide incorporation and destabilisation of a preformed serpin-enzyme complex following mAb4B12 binding. These data suggest that prematurely shifting the β-sheet A equilibrium towards the 'open' state out of sequence with other changes suppresses polymer formation. This work identifies a region potentially exploitable for a rational design of ligands that is able to dynamically influence α1-AT polymerisation

Airborne Mission Concept for Coastal Ocean Color and Ecosystems Research

NASA airborne missions in 2011 and 2013 over Monterey Bay, CA, demonstrated novel above- and in-water calibration and validation measurements supporting a combined airborne sensor approach (imaging spectrometer, microradiometers, and a sun photometer). The resultant airborne data characterize contemporaneous coastal atmospheric and aquatic properties plus sea-truth observations from state-of-the-art instrument systems spanning a next-generation spectral domain (320-875 nm). This airborne instrument suite for calibration, validation, and research flew at the lowest safe altitude (ca. 100 ft or 30 m) as well as higher altitudes (e.g., 6,000 ft or 1,800 m) above the sea surface covering a larger area in a single synoptic sortie than ship-based measurements at a few stations during the same sampling period. Data collection of coincident atmospheric and aquatic properties near the sea surface and at altitude allows the input of relevant variables into atmospheric correction schemes to improve the output of corrected imaging spectrometer data. Specific channels support legacy and next-generation satellite capabilities, and flights are planned to within 30 min of satellite overpass. This concept supports calibration and validation activities of ocean color phenomena (e.g., river plumes, algal blooms) and studies of water quality and coastal ecosystems. The 2011 COAST mission flew at 100 and 6,000 ft on a Twin Otter platform with flight plans accommodating the competing requirements of the sensor suite, which included the Coastal-Airborne In-situ Radiometers (C-AIR) for the first time. C-AIR (Biospherical Instruments Inc.) also flew in the 2013 OCEANIA mission at 100 and 1,000 ft on the Twin Otter below the California airborne simulation of the proposed NASA HyspIRI satellite system comprised of an imaging spectrometer and thermal infrared multispectral imager on the ER-2 at 65,000 ft (20,000 m). For both missions, the Compact-Optical Profiling System (Biospherical Instruments, Inc.), an in-water system with microradiometers matching C-AIR, was deployed to compare sea-truth measurements and low-altitude Twin Otter flights within Monterey Bay red tide events. This novel airborne and in-water sensor capability advances the science of coastal measurements and enables rapid response for coastal events