161 research outputs found

    The Ontology of Art: What Can We Learn from Borges鈥檚 "Menard"?

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    The question I want to analyze in this paper can be summarized as follows: what is the nature of works of art? This question can be divided into two separate ones: (1) what differential feature separate objects which are works of art from other objects which we usually do not consider as such?, and (2) to what kind of ontological category do works of art belong to? The recent discussions around this second topic are usually framed by the more traditional ontological discussion about universals. Thus, in order to answer the second question, philosophers generally use the distinction between universal-particular or type-token. But nobody would say that every universal (if she is universalist) or every particular (if particularist) is a work of art. Because works of art should have "something more". But what is this "something more"? In this paper I will try to answer these questions inspired by the ideas J.L. Borges developed in the short story: "Pierre Menard, author of the Quixote."Fil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas; Argentina. Universidad de Buenos Aires. Facultad de Filosof铆a y Letras; Argentin

    A Defense of Moderate Language Pluralism in Scholarly Production in the Humanities

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    In this paper we argue in favor of a moderate language plurilingualism in scholarly production in the humanities. We start by proposing some desiderata that a good policy regarding language use in the humanities should meet. We then survey institutional/policy options regarding the use of languages in the humanities and argue that different versions of monolingualism fall short of satisfying the desiderata. As a result, we consider different alternatives supporting plurilingualism and we defend that one of the options, that we call Moderate Language Pluralism or Moderate Plurilingualism, does better than the others vis-脿-vis the desiderata. Finally, we suggest some policies that would help to implement Moderate Plurilingualism.Fil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Sabat茅s, Marcelo. Columbia College; Estados Unido

    Understanding and Involvement with Art from the Second-Person Perspective

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    El trabajo muestra que la perspectiva de segunda persona de la atribuci贸n mental (P茅rez 2013 y P茅rez y Gomila 2021) puede contribuir a iluminar nuestra comprensi贸n e involucramiento con el arte. Una forma can贸nica de comprender nuestro involucramiento con el arte pone el foco en la noci贸n de empat铆a, que tambi茅n suele ser considerada una noci贸n central para dar cuenta de nuestro acceso a las otras mentes. En la primera parte del trabajo hago un breve repaso de esta noci贸n y la conecto con trabajos recientes en el 谩mbito de la filosof铆a del arte en los que se adopta una teor铆a simulacionista de nuestra comprensi贸n de las mentes y de la experiencia est茅tica. En segundo lugar, muestro las limitaciones que estas nociones (empat铆a y simulaci贸n) tienen para dar cuenta de nuestra comprensi贸n e involucramiento tanto con los dem谩s seres humanos como con el arte y expongo brevemente los lineamientos centrales de la perspectiva de segunda persona de la atribuci贸n psicol贸gica. Finalmente, muestro por qu茅 la perspectiva de segunda persona es m谩s adecuada para dar cuenta de las m煤ltiples y multifac茅ticas experiencias que surgen con el arte y las actividades art铆sticas.This paper shows that the second-person perspective of mental attribution (P茅rez 2013 and P茅rez and Gomila 2021) can contribute to illuminate our understanding and involvement with art. A canonical way of understanding our involvement with art focuses on the notion of empathy, which is also considered a central notion to account for our access to other minds. In the first part of this paper, I briefly review this notion and I connect it with recent works in the field of philosophy of art in which a simulationist theory is adopted, both to account for our understanding of other people鈥檚 minds and for understanding aesthetic experiences. Secondly, I show the limitations that these notions (empathy and simulation) have to account for our understanding and involvement both with other human beings and with art and I briefly expose the central thesis of the second person perspective of psychological attribution. Finally, I show why the second-person perspective is more adequate to account for the many and multifaceted experiences that arise with art and artistic activities.Fil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; Argentin

    Complementing the Analysis: Psychological Concepts and Color Concepts

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    En este trabajo presento dos tipos de conceptos, los conceptos psicol贸gicos y los conceptos de color y sugiero una ampliaci贸n de la tesis externista que defiende Axel Barcel贸 en su libro Sobre el an谩lisis.In this paper I present two types of concepts, psychological concepts and color concepts, and I suggest an extension of the externist thesis defended by Axel Barcel贸 in his book Sobre el an谩lisis.Fil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; Argentin

    Mirror Neurons: A Case Study of the Neuroscience-Philosophy Relationship

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    El descubrimiento del sistema de neuronas espejo, que acaeci贸 hace 25 a帽os, fue considerado por algunos autores como prueba definitiva de la superioridad de una teor铆a filos贸fica (la Teor铆a de la Simulaci贸n) por sobre otra (la Teor铆a de la Teor铆a). Sin emba go, esta pretensi贸n de haber encontrado una respuesta definitiva al problema filos贸fico de la comprensi贸n de las otras mentes a partir de datos neurocient铆ficos dista mucho de ser aceptable. En este trabajo mostrar茅 que existe una multiplicidad de interpretaciones posibles relativas al rol de las neuronas espejo, y que una de las m谩s plausibles parece congruente con la perspectiva de segunda persona (P茅rez y Gomila 2021). La conclusi贸n que busco extraer de este caso de estudio es que no hay caminos directos desde la neurociencia a la soluci贸n de (al menos algunos) problemas filos贸ficos.The discovery of the mirror neuron system, which occurred 25 years ago, was considered by some authors as a definitive proof of the superiority of one philosophical theory (the Simulation Theory) over another (the Theory of Theory). However, the claim to have found a definitive answer to the philosophical problem of understanding other minds from neuroscientific data is far from acceptable. In this work I will show that there is a multiplicity of possible interpretations regarding the role of mirror neurons, and that one of the most plausible seems consistent with the second-person perspective (P茅rez and Gomila 2021). The conclusion I seek to draw from this case study is that there are no direct paths from neuroscience to the solution of (at least some) philosophical problems.Fil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; Argentin

    The Second Person Perspective and the Music

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    En este trabajo exploraremos las posibilidades que la perspectiva de segunda persona, una teor铆a postcognitiva de la cognici贸n social, le ofrece a la psicolog铆a de la m煤sica. En primer lugar, repasaremos las diferentes concepciones de la m煤sica que han dado forma a las maneras cl谩sicas de abordar este fen贸meno en el 谩mbito de la psicolog铆a de la m煤sica subra-yando algunas de sus limitaciones. En segundo lugar, destacaremos el car谩cter social de la m煤sica y el papel de la revoluci贸n postcognitiva en los estudios de la m煤sica, como preludio a una nueva perspectiva te贸rica en este 谩mbito disciplinar. En tercer lugar, presentaremos la perspectiva de segunda persona dentro del marco postcognitivo de la cognici贸n social que nos permitir谩 profundizar en la revoluci贸n corporizada en estos estudios. Finalmente, exploraremos las posibilidades que esta perspectiva ofrece para un abordaje alternativo del fen贸meno musical y resumiremos algunas de las conclusiones preliminares que pueden extraerse de la adopci贸n de esta perspectiva para el estudio de la pr谩ctica musicalIn this paper we explore the possibilities that the second person perspective, a postcognitive theory of social cognition, offers to the psychology of music. In the first place, we will review the different conceptions of music that have shaped the classical ways of approaching this phenomenon in the field of music psychology, highlighting some of its limitations. Secondly, we will take the social character of music as a starting point and remark the role of the postcognitive revolution in music studies, as a prelude to a new theoretical perspective in this field. Thirdly, we will present the second-person perspective within the postcognitive framework of social cognition that will allow us to delve into the revolution embodied in these studies. Finally, we will explore the possibilities that this perspective offers for an alternative approach to the musical phenomenon and we will summarize some of the preliminary conclusions that can be drawn from the adoption of this second-person perspective for the study of musical practice.Fil: Martinez, Isabel Cecilia. Universidad Nacional de La Plata. Facultad de Bellas Artes; ArgentinaFil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; Argentin

    Linguistic Relativity, Gender Grammar and Inclusive Language: Some Considerations

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    En este art铆culo examinaremos un caso de aplicaci贸n de la hip贸tesis de la relatividad ling眉铆stica (HRL): la influencia del g茅nero gramatical de las lenguas sobre la cognici贸n o el pensamiento de los hablantes. Dado que las lenguas difieren tanto en sus repertorios l茅xicos como sobre todo en sus gram谩ticas de g茅nero para referir a las personas, a otras entidades animadas e incluso a entidades inanimadas, nuestro prop贸sito ser谩, en primer lugar, revisar la evidencia experimental reciente que avalar铆a la HRL en este dominio, al comprobar una variedad de impactos cognitivos y psicol贸gicos, variables seg煤n las lenguas de los hablantes. En particular, identificaremos cu谩les son los "efectos relativistas" en el caso de los rasgos morfosint谩cticos de las lenguas con carga de g茅nero, y en relaci贸n con la universalizaci贸n del g茅nero masculino. Sobre la base de la evaluaci贸n realizada e incorporando los aportes de los estudios de "g茅nero y lenguaje" de los enfoques feministas, concluiremos se帽alando de qu茅 diversas maneras es viable e importante promover usos inclusivos del lenguaje e incluso cambios m谩s profundos hacia un lenguaje inclusivo, con especial referencia al espa帽ol.In this paper, we examine a case of application of the hypothesis of linguistic relativity (HLR): the influence of the grammatical gender of languages on the cognition or thinking of speakers. Since languages differ both in their lexical repertoires, but, specially, in their gender grammars to refer to people, other animated beings and even inanimate entities, our purpose will be, first, to review the recent experimental evidence that would support the HLR on this domain, because they verify a variety of cognitive and psychological impacts, variable according to the languages of the speakers. In particular, we will identify what are the 鈥渞elativist effects鈥 in the case of morphosyntactic features of gender-loaded languages and in a relation to the universalization of the male gender. Based on the evaluation carried out and incorporating the contributions of 鈥済ender and language鈥 studies of feminist approaches, we will conclude by pointing out in what ways it is viable and important to promote inclusive uses of language and even deeper changes towards an inclusive language, with special reference to Spanish.Fil: Scotto, Silvia Carolina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Centro Cient铆fico Tecnol贸gico Conicet - C贸rdoba. Instituto de Humanidades. Universidad Nacional de C贸rdoba. Instituto de Humanidades; ArgentinaFil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; Argentin

    Naturalmente transhumanos

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    This work promotes the thesis that humans are naturally transhuman. In order to achieve this,we present in the first two sections some examples of technological devices assembled to human beings, and we critically review the assumptions and dichotomies on which the idea of human enhancement is based according to the ordinary transhumanist vision. Thirdly, we present the thesis of the Extended Mind to support our intuition. Fourthly, we dismantle the most relevant philosophical dichotomies that structure the transhumanist position. Finally, we recapitulate the reasons why we should wake up from the transhumanist dream.Fil: Pedace, Karina Silvia. Universidad de Buenos Aires; Argentina. Universidad Nacional de La Matanza; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Balmaceda Huarte, Tomas. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Lawler, Diego. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Perez, Diana Ines. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Zeller Echenique, Maximiliano. Universidad de Buenos Aires; Argentin

    Algunas cuestiones 茅ticas a prop贸sito de la pandemia de Covid-19

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    El nuevo coronavirus no tiene problemas 茅ticos, pues estos son problemas humanos. Como seres capaces de actuar en forma razonada y libre, tambi茅n debemos considerar la responsabilidad de nuestra conducta y de nuestras respuestas individuales y colectivas ante a la pandemia de Covid-19. As铆, mientras analizamos los problemas 茅ticos y respondemos a la emergencia sanitaria fortaleciendo nuestros sistemas de salud y de investigaci贸n, resultar铆a beneficioso contar con un objetivo final que organice y dirija nuestra acci贸n. Mantener, proteger y promover la pluralidad de planes de vida com煤n que permite la democracia constitucional en la Argentina merece ser tal objetivo.Fil: Bianchini, Alahi Dana. Universidad de Buenos Aires. Facultad de Derecho. Instituto de Investigaciones Jur铆dicas y Sociales "Dr. Ambrosio L. Gioja"; Argentina. Facultad Latinoamericana de Ciencias Sociales; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas; ArgentinaFil: Rivera L贸pez, Eduardo Enrique. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Luna, Florencia. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas; Argentina. Facultad Latinoamericana de Ciencias Sociales. Sede Acad茅mica Argentina Buenos Aires. Programa de Bio茅tica; ArgentinaFil: Alegre, Marcelo. Universidad de Buenos Aires. Facultad de Derecho. Instituto de Investigaciones Jur铆dicas y Sociales "Dr. Ambrosio L. Gioja"; ArgentinaFil: Perez, Diana Ines. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas. Oficina de Coordinaci贸n Administrativa Parque Centenario. Instituto de Investigaciones Filos贸ficas. - Sociedad Argentina de An谩lisis Filos贸fico. Instituto de Investigaciones Filos贸ficas; ArgentinaFil: Mastroleo, Ignacio Damian. Facultad Latinoamericana de Ciencias Sociales. Sede Acad茅mica Argentina Buenos Aires. Programa de Bio茅tica; Argentina. Consejo Nacional de Investigaciones Cient铆ficas y T茅cnicas; Argentin

    Pranlukast Antagonizes CD49f and Reduces Sternness in Triple-Negative Breast Cancer Cells

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    Introduction: Cancer stem cells (CSCs) drive the initiation, maintenance, and therapy response of breast tumors. CD49f is expressed in breast CSCs and functions in the maintenance of stemness. Thus, blockade of CD49f is a potential therapeutic approach for targeting breast CSCs. In the present study, we aimed to repurpose drugs as CD49f antagonists. Materials and Methods: We performed consensus molecular docking using a subdomain of CD49f that is critical for heterodimerization and a collection of pharmochemicals clini-cally tested. Molecular dynamics simulations were employed to further characterize drug-target binding. Using MDA-MB-231 cells, we evaluated the effects of potential CD49f antagonists on 1) cell adhesion to laminin; 2) mammosphere formation; and 3) cell viability. We analyzed the effects of the drug with better CSC-selectivity on the activation of CD49f-downstream signaling by Western blot (WB) and co-immunoprecipitation. Expressions of the stem cell markers CD44 and SOX2 were analyzed by flow cytometry and WB, respectively. Transactivation of SOX2 promoter was evaluated by luciferase reporter assays. Changes in the number of CSCs were assessed by limiting-dilution xenotransplantation. Results: Pranlukast, a drug used to treat asthma, bound to CD49f in silico and inhibited the adhesion of CD49f+ MDA-MB-231 cells to laminin, indicating that it antagonizes CD49f-containing integrins. Molecular dynamics analysis showed that pranlukast binding induces con-formational changes in CD49f that affect its interaction with 尾1-integrin subunit and constrained the conformational dynamics of the heterodimer. Pranlukast decreased the clonogenicity of breast cancer cells on mammosphere formation assay but had no impact on the viability of bulk tumor cells. Brief exposure of MDA-MB-231 cells to pranlukast altered CD49f-dependent signaling, reducing focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3K) activation. Further, pranlukast-treated cells showed decreased CD44 and SOX2 expression, SOX2 promoter transacti-vation, and in vivo tumorigenicity, supporting that this drug reduces the frequency of CSC. Conclusion: Our results support the function of pranlukast as a CD49f antagonist that reduces the CSC population in triple-negative breast cancer cells. The pharmacokinetics and toxicology of this drug have already been established, rendering a potential adjuvant therapy for breast cancer patients
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