183 research outputs found

    A counting multidimensional innovation index for SMEs

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    We developed a C ounting Multidimensional Innovation Index (MII) framework for measuring and benchmarking innovation of Small and Medium Enterprises (SMEs) , groups of SMEs, industries , regions, and countries . The methodology behind the MII is similar to the methodology behind the United Nations Multi dimensional Poverty Index and follows the innovation definitions stipulated by the OECD Oslo Manual , cover ing dime n s ions and partial indicators suggested by this Ma nual and/or adapted from the In novation Union Scoreboard (IUS) and from the Global Innovation Index (GII) . T o illustrate the MII framework , a survey was conducted among SME s of the metalworking industry in Portugal .info:eu-repo/semantics/publishedVersio

    A counting multidimensional innovation index for SMEs

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    Purpose: The purpose of this paper is to develop a multidimensional innovation index (MII) framework for measuring and benchmarking multidimensional innovation of small and medium enterprises (SMEs) and groups of SMEs. Design/methodology/approach: A counting dual cut-off method is employed. First, output and input innovation profiles and composite scores of individual SMEs are computed. Second, a set of four composite innovation indices are generated characterizing the group of SMEs under analysis: MIIo and MIIi measure multidimensional output and input innovation, respectively; while MIIr and MIIa assess the ratio and average of MIIo and MIIi, respectively. To test the MII framework, a survey was conducted among SMEs of the metalworking industry in Portugal. Findings: In 2012, about 28.9 percent (42.2 percent) SMEs of the Portuguese metalworking industry were determined to be multidimensional output (input) innovative. The average percentage of dimensions for which output (input) innovative SMEs were innovative was 65.0 percent (66.0 percent). Thus, the industry MII vector was (MIIo; MIIi; MIIr; MIIa)¬ľ (0.188, 0.279, 0.674; 0.233). Significant differences were found across the industry, individual SMEs‚Äô multidimensional output and input innovation scores, enabling the identification of groups of SMEs, which can be characterized and compared by computing the corresponding and specific MII vectors. Research limitations/implications: The research has limitations because of the small size of the sample and the benchmarking possibilities it provides. Originality/value The novelty of the MII framework lies in the counting dual cut-off method employed.info:eu-repo/semantics/acceptedVersio

    Como as coliga√ß√Ķes ciclistas modificam a cultura da bicicleta: an√°lise da mudan√ßa na pol√≠tica de mobilidade em Lisboa 2009-2021

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    Cycling is currently recognised as a vital part of most developed sustainable urban mobility systems, contributing to acknowledged gains in climate change mitigation, health, social, economic, environmental, and travel speed issues, explaining in part its recent resurgence in cities worldwide. Despite the benefits, public policy on cycling has not developed smoothly. Many cities continue to stall or ignore effective output implementation to promote cycling as a legitimate mobility mode. Most research and policy focus on infrastructure solutions to implement change. This research, by contrast, focuses on an innovative approach to advance scholarship, namely how cyclists‚Äô advocacy coalitions shape decision-making and place cycling on the political agenda where it was previously ignored or side-lined. The dissertation applies the concept of the advocacy coalition framework (ACF) to analyse the mechanisms which activate and sustain policy change. This thesis analyses the city of Lisbon in Portugal as a case-study of conurbation to analyse how change has been leveraged during the thirteen-year time frame between 2009 and 2021, using both detailed comparative analysis and advancing scholarship on cycling more generally. The qualitative analysis employs the scholarship, documents, notes taken from personal professional experience in policy formulation and implementation, and eleven anonymous interviews with policy actors involved to different extents in the process during the study period. These quantitative outcomes are gauged using available data from several surveys and counts to substantiate the relation between the outputs produced and outcomes achieved in combination with detailed data from cycle traffic moving counts I have carried out since 2009. The research structure is designed to provide insights on how the broad-based cyclists‚Äô coalition has shaped policy formulation and implementation in a city where cycling had a low cultural status and low rates to generate ‚Äėnew knowledge‚Äô regarding the subsystem in Portugal and other comparable contexts.A utiliza√ß√£o da bicicleta √© atualmente reconhecida como parte vital do sistema de mobilidade urbana sustent√°vel das cidades mais desenvolvidas, contribuindo para ganhos na mitiga√ß√£o das altera√ß√Ķes clim√°ticas, benef√≠cios de sa√ļde, sociais, econ√≥micos, ambientais, e na velocidade das desloca√ß√Ķes, explicando em parte o recente ressurgimento deste modo em cidades por todo o mundo. Apesar destes benef√≠cios, as pol√≠ticas p√ļblicas n√£o se t√™m desenvolvido facilmente nesta mat√©ria. Muitas cidades continuam a atrasar ou a excluir a implementa√ß√£o de medidas efetivas para promover a bicicleta como modo de mobilidade leg√≠timo. A maioria das investiga√ß√Ķes e pol√≠ticas remetem para solu√ß√Ķes infraestruturais para fomentar a transi√ß√£o. Esta investiga√ß√£o, por outro lado, emprega uma abordagem inovadora para o avan√ßo do conhecimento, designadamente, como as coliga√ß√Ķes de utilizadores de bicicleta transformam o processo de decis√£o e colocam a bicicleta na agenda pol√≠tica onde antes este modo de mobilidade era ignorado ou marginalizado. A disserta√ß√£o adota a base te√≥rica do ‚Äėadvocacy coalition framework‚Äô (ACF) para analisar os mecanismos que ativam e sustentam a mudan√ßa de pol√≠ticas. Esta tese analisa a cidade de Lisboa em Portugal como caso de estudo, considerando a conurba√ß√£o, para analisar como a mudan√ßa foi realizada durante o per√≠odo de treze anos entre 2009 e 2021, empregando an√°lises comparativas detalhadas para avan√ßar no conhecimento sobre a utiliza√ß√£o da bicicleta em geral. A an√°lise qualitativa analisou a literatura cient√≠fica, documentos, notas provenientes da experi√™ncia pessoal e profissional na formula√ß√£o e implementa√ß√£o de pol√≠ticas, e onze entrevistas an√≥nimas com variados atores pol√≠ticos, envolvidos no processo durante o per√≠odo do estudo de diferentes formas. Os resultados quantitativos s√£o analisados atrav√©s de dados dispon√≠veis provenientes de diferentes pesquisas e contagens para fundamentar a rela√ß√£o entre as medidas implementadas e os resultados alcan√ßados, complementados com dados pormenorizados de contagens de tr√°fego cicl√°vel realizados desde 2009. A estrutura desta investiga√ß√£o foi projetada para aprofundar o conhecimento sobre a ampla coliga√ß√£o de utilizadores de bicicleta e como esta transformou a formula√ß√£o e implementa√ß√£o de pol√≠ticas, numa cidade onde o status cultural e as taxas de utiliza√ß√£o da bicicleta eram reduzidos, para gerar 'novo conhecimento' sobre o subsistema em Portugal e outros contextos compar√°veis.Programa Doutoral em Pol√≠ticas P√ļblica

    Visualização em tempo real de um modelo esparso de mistura paramétrica para síntese da BTF

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    As fun√ß√Ķes de textura bidirecionais (Bidirectional Texture Functions - BTF) permitem visualiza√ß√Ķes de alta qualidade de materiais reais, que exibem detalhes complexos na sua apar√™ncia, e que n√£o podem ser fielmente representados por fun√ß√Ķes param√©tricas mais simples. Representa√ß√Ķes f√≠eis deste tipo de materiais requerem grandes quantidades de dados, dificultando a sua visualiza√ß√£o em tempo real. A compress√£o de BTFs constitui um compromisso entre qualidade visual e tempo de s√≠ntese. Este artigo apresenta um visualizador a correr integralmente no GPU, usando um motor de ray tracing, de uma representa√ß√£o recente para BTFs, o Modelo Esparso de Mistura Param√©trica (Sparse Parametric Mixture Model - SPMM). A escalabilidade com o n√ļmero de BTFs e o n√ļmero de luzes √© tamb√©m estudado.Funda√ß√£o para a Ci√™ncia e Tecnologi

    Experimental evaluation of distributed middleware with a virtualized java environment

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    The correctness and performance of large scale service oriented systems depend on distributed middleware components performing various communication and coordination functions. It is, however, very difficult to experimentally assess such middleware components, as interesting behavior often arises exclusively in large scale settings, but such deployments are costly and time consuming. We address this challenge with MINHA, a system that virtualizes multiple JVM instances within a single JVM while simulating key environment components, thus reproducing the concurrency, distribution, and performance characteristics of the actual system. The usefulness of MINHA is demonstrated by applying it to the WS4D Java stack, a popular implementation of the Devices Profile for Web Services (DPWS) specification.(undefined

    Um sistema de indicadores de inova√ß√£o para as pequenas e m√©dias empresas do setor metal√ļrgico e metalomec√Ęnico

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    O presente estudo tem como objetivo desenvolver um sistema de indicadores de inova√ß√£o para as PME do setor metal√ļrgico e metalomec√Ęnico (MM), que possa servir de bar√≥metro ao estado da inova√ß√£o das empresas deste setor. O sistema de indicadores desenvolvidos teve como suporte sistemas de indicadores j√° existentes, em particular, o Innovation Union Scoreboard (IUS), o Global Innovation Index (GII) e o Multidimensional Poverty Index (MPI), bem como um inqu√©rito realizado √†s PME do setor. Tal como os sistemas IUS e GII, o sistema de indicadores desenvolvido cobre dimens√Ķes de inova√ß√£o que dizem respeito a esfor√ßos de inova√ß√£o ou inputs e a resultados de inova√ß√£o ou outputs. Tendo por base os indicadores parciais nas dimens√Ķes consideradas para as PME do setor e a filosofia do MPI, construiu-se um vetor Multidimensional Innovation Indexe (MII) com tr√™s indicadores, um referente aos outputs da inova√ß√£o (MIIo), outro aos inputs para a inova√ß√£o (MIIi) e um terceiro correspondente ao r√°cio entre os dois primeiros (MIIr). O MIIo e o MIIi s√£o dois indicadores globais que refletem a intensidade m√©dia e a incid√™ncia da inova√ß√£o no setor, respetivamente, em termos de outputs e inputs. O MIIr √© um indicador global que mede a produtividade m√©dia da inova√ß√£o no setor. O inqu√©rito conduzido refletiu a l√≥gica de recolha de informa√ß√£o do MPI com perguntas de resposta sim ou n√£o, tendo havido preocupa√ß√£o com a simplicidade e a facilidade de resposta ao mesmo por parte das PME do setor. Os principais resultados do MII para o ano de 2012 indicam que 29% das PME do setor MM eram inovadoras em termos de outputs e que 42% eram inovadoras em termos de inputs. . A intensidade m√©dia de inova√ß√£o foi de 63% para os outputs e 61% para os inputs. Assim, para as PME do setor o valor do MIIo era 0,175, o valor do MIIi era 0,267 e o valor do MIIr era 0,654. Existem diferen√ßas significativas em termos de inova√ß√£o nas PME do setor conforme o n√ļmero de trabalhadores por PME, a distribui√ß√£o geogr√°fica das mesmas por NUTS III, a CAE √† qual pertencem bem como a forma de natureza jur√≠dica assumida pela empresa. As PME com maior escala ‚Äď mais trabalhadores ‚Äď tendem a ser mais inovadoras do que aquelas com menos trabalhadores, assim como as PME das sub-regi√Ķes do Ave e Pinhal Litoral, e as sociedades unipessoaisThe aim of this work is to develop a system of indicators of innovation for SME in the metalworking industry, which can serve as a barometer of the innovation‚Äôs state of the industry. The system of indicators developed had as its support existing indicator systems, in particular, the Innovation Union Scoreboard (IUS), the Global Innovation Index (GII) and Multidimensional Poverty Index (MPI), as well as a survey performed to the sector‚Äôs SME. Just like the IUS and GII systems, the system covers innovation dimensions which refer to innovation efforts - or inputs - and outcomes of innovation ‚Äď outputs. Based on the partial indicators in the dimensions considered for the sector‚Äôs SME and on the MPI‚Äôs philosophy, a Multidimensional Innovation Indexe vector has been built with three indicators, one regarding outputs of innovation (MIIo), another to efforts or inputs of innovation (MIIi), and the third being the ratio between the first two Indexes (MIIr). The MIIo and MIIi are two global indicators that reflect the average intensity and incidence of innovation, respectively, in terms of outputs and inputs in the sector. The MIIr is a global indicator that measures the average productivity of innovation in the sector. The survey conducted reflected the logic of gathering information from the MPI with questions of answers yes or no, and there was concern about the simplicity and ease of response to it on the part of the sector‚Äôs SME. The main results of MII indicate that 29% of SME in the metalworking industry, during 2012, were innovative in terms of outputs, while 42% were innovative in terms of inputs . The innovation average intensity was 63% for outputs and 61% for inputs. Thus, for the sector‚Äôs SME, the value of MIIo was 0.175, the value of the MIIi was 0.267 and the value of MIIr was 0.654. There are significant differences in terms of innovation concerning the number of employees per SME, the geographic distribution by NUTS III, the CAE to which they belong and the manner of legal nature assumed by the company. SME with larger scale - more workers - are more innovative than those with smaller scale, as well as SME in sub-regions of Ave and Pinhal Litoral, and sole proprietorships

    Bombaim, a explos√£o urbana : an√°lise de assentamentos e vias

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    Tese de mestrado. Planeamento e Projecto do Ambiente Urbano. Faculdade de Engenharia. Universidade do Porto, Massachussets Institute of Technology. 200

    Um Exame Cl√≠nico Objetivo Estruturado para Avaliar Aptid√Ķes de Semiologia em Alunos de Medicina

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    Introduction: Mastery of history taking and physical exam skills is a key competence of medical students. Objective Structured Clinical Examinations are the gold standard to assess these competencies, but their implementation in Portugal is poorly documented. We describe the implementation and our seven years experience with a high-stakes Objective Structured Clinical Examination to assess these skills in the School of Medicine, University of Minho. Material and Methods: Our Objective Structured Clinical Examination is in place since 2010 and has been subject to continuous improvements, including the adoption of a standard setting procedure and an increase in the number of stations. Results: Grades in our exam are well distributed and discriminate among students. History taking grades are lower and have remained stable throughout the years while physical examination scores have risen. The exam is reliable, with internal consistency above 0.45 and a G-coefficient of 0.74. It is also feasible, with a total testing time of approximately 20 hours for 140 students, and the involvement of 18 standardized patients and 18 faculty assessors. More importantly, it was able to engage the students, who recognize its importance. Discussion: The most important validity criterion of our, and any Objective Structured Clinical Examination, would be predictive validity, the ability to predict the performance of students in the clinical context. Conclusion: Our approach to a high-stakes Objective Structured Clinical Examination shows that it is feasible, reliable, valid and fair and can be implemented with success in the Portuguese setting.Introdu√ß√£o: O dom√≠nio das aptid√Ķes de colheita de hist√≥ria e do exame f√≠sico √© uma compet√™ncia chave para os estudantes de medicina. Os Exames Cl√≠nicos Objetivos Estruturados s√£o o padr√£o para avaliar estas compet√™ncias, mas a sua implementa√ß√£o em Portugal est√° pouco documentada. Descrevemos a implementa√ß√£o e a nossa experi√™ncia de sete anos, com um Exame Cl√≠nico Objetivo Estruturado para avaliar estas aptid√Ķes na Escola de Medicina da Universidade do Minho. Material e M√©todos: O nosso Exame Cl√≠nico Objetivo Estruturado existe desde 2010 e tem sido sujeito a melhorias cont√≠nuas, das quais se destacam a ado√ß√£o de um procedimento de standard setting e o aumento do n√ļmero de esta√ß√Ķes. Resultados: As notas no nosso exame est√£o bem distribu√≠das e discriminam entre estudantes. As notas da colheita da hist√≥ria s√£o inferiores e t√™m permanecido est√°veis ao longo do tempo, enquanto as do exame f√≠sico t√™m aumentado. O exame √© fi√°vel, tendo uma consist√™ncia interna acima de 0,45 e um coeficiente G de 0,74. Tamb√©m √© pratic√°vel, tendo um tempo total de teste de 20 horas para 140 alunos, envolvendo 18 pacientes estandardizados e 18 examinadores. Mais importante, o Exame Cl√≠nico Objetivo Estruturado foi capaz de cativar os estudantes, que reconhecem a sua import√Ęncia para a sua forma√ß√£o. Discuss√£o: O mais importante crit√©rio de valor do nosso, e de qualquer outro Exame Cl√≠nico Objetivo Estruturado, ser√° o seu valor preditivo, que se traduz na faculdade de prever o desempenho dos estudantes em contexto cl√≠nico. Conclus√£o: A nossa abordagem para um Exame Cl√≠nico Objetivo Estruturado mostra que √© pratic√°vel, fi√°vel, v√°lido e justo e que pode ser implementado com sucesso no contexto portugu√™sinfo:eu-repo/semantics/publishedVersio

    Tomato processing by-products valorisation through ohmic heating approach

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    Tomato by-products from processing industries have a higher potential to be reused as a source of bioactive compounds. Reliable national data on tomato by-products and physicochemical characterisation that will inform and find effective planning on tomato waste management in Portugal is absent. To help obtain this knowledge, selected Portugal companies were recruited to obtain representative samples of by-products generation, and physicochemical composition was evaluated. Furthermore, an environmental-friendly method (the ohmic heating (OH) method, which allows the recovery of bioactive compounds in absence of hazardous reagents) was also used and compared with conventional methods to explore new safe value-added ingredients. Total antioxidant capacity and total and individual phenolic compounds were also evaluated by spectrophotometric and high-performance liquid chromatography (HPLC), respectively. Tomato processing by-products have revealed a higher potential since both collected samples from companies were rich in protein (between 16.3 to 19.4 g/100 g DW, with fibre content ranging from 57.8 to 59.0 g/100 g DW). In addition, these samples contain 17.0 g/100 g of fatty acids (mainly polyunsaturated, monounsaturated and saturated, such as linoleic, oleic, and palmitic acid, respectively). Also, they present mainly chlorogenic acid and rutin as phenolic compounds. After understanding its composition, the OH was applied to determine added-value solutions to tomato by-products. With extractions, two types of fractions were obtained, namely liquid fraction rich in phenols, free sugars, and carotenoids and a solid fraction rich in fibre bound to phenols and carotenoids. This treatment has been shown to have the ability to preserve carotenoids, such as lycopene relative to conventional methods. Nevertheless, new molecules were identified by LC-ESI-UHR-OqTOF-MS analysis, such as phene-di-hexane and N-acethyl-D-tryptophan. According to the results, the OH boosts the potential of tomato by-products and can be directly introduced into the process, contributing to the circular economy and zero by-products.This research was funded by ‚ÄúMultiBiorefinery: Estrat√©gias multiuso para a valoriza√ß√£o de uma gama alargada de subprodutos agroflorestais e das pescas: Um passo em frente na cria√ß√£o de uma biorrefinaria‚ÄĚ financiado pelo Programa Operacional Competitividade e Internacionaliza√ß√£o (POCI-01-0145-FEDER-016403) e pelo Programa Operacional Regional de Lisboa (LISBOA-01-0145- FEDER-016403), na sua componente FEDER e pela Funda√ß√£o para a Ci√™ncia e Tecnologia, I.P. na componente nacional (SAICTPAC/0040/2015).info:eu-repo/semantics/publishedVersio

    Hipertensão pulmonar tromboembólica crónica: experiência inicial de doentes submetidos a tromboendarterectomia pulmonar

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    ¬© 2021 Published by Elsevier Espa√Īa, S.L.U. on behalf of Sociedade Portuguesa de Cardiologia. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Introduction and objectives: Pulmonary endarterectomy (PEA) is a potentially curative procedure in patients with chronic thromboembolic pulmonary hypertension (CTEPH). This study reports the initial experience of a Portuguese PH center with patients undergoing PEA at an international surgical reference center. Methods: Prospective observational study of consecutive CTEPH patients followed at a national PH center, who underwent PEA at an international surgical reference center between October 2015 and March 2019. Clinical, functional, laboratory, imaging and hemodynamic parameters were obtained in the 12 months preceding the surgery and repeated between four and six months after PEA. Results: 27 consecutive patients (59% female) with a median age of 60 (49-71) years underwent PEA. During a median follow-up of 34 (21-48) months, there was an improvement in functional class in all patients, with only one cardiac death. From a hemodynamic perspective, there was a reduction in mean pulmonary artery pressure from 48 (42-59) mmHg to 26 (22-38) mmHg, an increase in cardiac output from 3.3 (2.9-4.0) L/min to 4.9 (4.2-5.5) L/min and a reduction in pulmonary vascular resistance from 12.1 (7.2-15.5) uW to 3.5 (2.6-5,2) uW. During the follow-up, 44% (n=12) of patients had no PH criteria, 44% (n=12) had residual PH and 11% (n=3) had PH recurrence. There was a reduction of N-terminal pro-B-type natriureticpeptide from 868 (212-1730) pg/mL to 171 (98-382) pg/mL. Rright ventricular systolic function parameters revealed an improvement in longitudinal systolic excursion and peak velocity of the plane of the tricuspid ring from 14 (13-14) mm and 9 (8-10) cm/s to 17 (16-18) mm and 13 (11-15) cm/s, respectively. Of the 26 patients with preoperative right ventricular dysfunction, 85% (n=22) recovered. The proportion of patients on specific vasodilator therapy decreased from 93% to 44% (p<0.001) and the proportion of those requiring oxygen therapy decreased from 52% to 26% (p=0.003). The six-minute walk test distance increased by about 25% compared to the baseline and only eight patients had significant desaturation during the test. Conclusion: Pulmonary endarterectomy performed at an experienced high-volume center is a safe procedure with a very favorable medium-term impact on functional, hemodynamic and right ventricular function parameters in CTEPH patients with operable disease. It is possible for PH centers without PEA differentiation to refer patients safely and effectively to an international surgical center in which air transport is necessary.Introdu√ß√£o e objetivos A tromboendarterectomia pulmonar (TP) √© um procedimento potencialmente curativo em doentes com hipertens√£o pulmonar (HP) tromboemb√≥lica cr√≥nica (TEC). O objetivo deste trabalho √© reportar a experi√™ncia inicial de um centro portugu√™s de tratamento de HP em doentes submetidos a TP num centro de refer√™ncia cir√ļrgico internacional. M√©todos Estudo observacional prospetivo de doentes consecutivos com diagn√≥stico de CTEPH seguidos em centro nacional de tratamento de HP e submetidos a TP em centro de refer√™ncia cir√ļrgico internacional entre outubro de 2015 e mar√ßo de 2019. Par√Ęmetros cl√≠nicos, funcionais, laboratoriais, imagiol√≥gicos e hemodin√Ęmicos foram obtidos nos 12 meses precedentes √† cirurgia e repetidos entre quatro a seis meses ap√≥s a TP. Resultados Foram submetidos a TP 27 doentes consecutivos (59% do sexo feminino) com mediana de 60 (49-71) anos. Durante um seguimento mediano de 34 (21-48) meses, verificou‚Äźse melhoria da classe funcional em todos os doentes, tendo ocorrido apenas um √≥bito de causa card√≠aca. Do ponto de vista hemodin√Ęmico, observou‚Äźse redu√ß√£o da press√£o m√©dia na art√©ria pulmonar de 48 (42-59) mmHg para 26 (22-38) mmHg, aumento do d√©bito card√≠aco de 3,3 (2,9-4,0) L/min para 4,9 (4,2-5,5) L/min e redu√ß√£o das resist√™ncias vasculares pulmonares de 12,1 (7,2-15,5) uW para 3,5 (2,6-5,2) uW. Tendo em conta os par√Ęmetros hemodin√Ęmicos avaliados p√≥s‚ÄźTP e a sua evolu√ß√£o durante o seguimento cl√≠nico, 44% (n = 12) dos doentes deixaram de ter crit√©rios de HP, 44% (n = 12) mantiveram HP e 11% (n = 3) evolu√≠ram com recorr√™ncia de HP. Laboratorialmente, a salientar redu√ß√£o do NT‚ÄźproBNP de 868 (212‚Äď1730) pg/mL para 171 (98‚Äď382) pg/mL. Dos par√Ęmetros de fun√ß√£o sist√≥lica ventricular direita, verificou‚Äźse melhoria da excurs√£o e velocidade de pico sist√≥licas longitudinais do plano do anel tric√ļspide de 14 (13-14) mm e 9 (8-10) cm/s para 17 (16-18) mm e 13 (11-15) cm/s, respetivamente. Dos 26 doentes com crit√©rios de disfun√ß√£o sist√≥lica ventricular direita pr√©‚Äźcirurgia, 85% (n = 22) apresentaram crit√©rios de recupera√ß√£o. A propor√ß√£o de doentes sob terap√™utica vasodilatadora espec√≠fica diminuiu de 93% para 44% (p < 0,001) e a propor√ß√£o daqueles requerendo OLD diminuiu de 52% para 26% (p = 0,003). A dist√Ęncia percorrida no teste dos seis minutos de marcha aumentou em cerca de 25% relativamente ao valor pr√©vio √† interven√ß√£o cir√ļrgica e apenas oito doentes mantiveram dessatura√ß√£o significativa durante a prova. Conclus√£o A TP realizada em centro cir√ļrgico de elevado volume √© um procedimento seguro e com impacto muito favor√°vel em m√©dio prazo nos par√Ęmetros funcionais, hemodin√Ęmicos e de fun√ß√£o ventricular direita em doentes com HPTEC oper√°vel. √Č poss√≠vel, para centros de tratamento de HP sem diferencia√ß√£o em TP, a referencia√ß√£o dos doentes com seguran√ßa e efetividade a um centro cir√ļrgico internacional em que para tal seja necess√°rio aerotransporte.info:eu-repo/semantics/publishedVersio
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