Data_Sheet_1_Internet search data showed increased interest in supplementary online education during the COVID-19 pandemic, with females showing a greater increase.pdf

The COVID-19 pandemic has led to tremendous disruptions in people’s everyday activities, including the pursuit of education. Internet search data may provide insights into potential audiences’ interest in online education. Using Internet search data, we examined the impact of COVID-19 on people’s interest in supplementary online education in the US over nine months (10/14/2019–07/19/2020). We found there was increased interest in supplementary online education after WHO announced COVID-19 as a pandemic, with a greater increase among females than males. We found that the increased interest in online education persisted after the stay-at-home orders were lifted; in addition, we identified concerns over unemployment as a key variable that significantly explained the variance in the interest in online education, even after controlling for COVID cases and deaths. Policymakers and online education platforms may take advantage of people’s, especially women’s increased interest in online education when designing policies or marketing mix.</p

Synthesis of Oxidant Prone Nanosilver To Develop H₂O₂ Responsive Drug Delivery System

Our immune system uses toxicity of hydrogen peroxide to kill off bacterial invaders. In this contribution, we intended to integrate ROS producing capability of immune system with oxidant-sensitive nature of antibacterial silver nanoparticles (Ag NPs) to develop an oxidant drug delivery system. Prior to execute this strategy, we have developed an efficient one-pot synthetic protocol to produce ultrasmall (5 nm), water-stable, and oxidant-prone Ag NPs. Notably, the yield of as-synthesized Ag NPs is 10-fold higher than standard citrate reduction route. The resulting therapeutically active and well-dispersed Ag NPs are used as nanolids to cap the drug loaded nanochannels of porous silica. Upon exposing to H₂O₂, dissolution-accompanied aggregation of Ag nanolids unleashes the encapsulated therapeutic entities from channels of nanocarrier. Combination of antibacterial and anti-inflammatory drugs in single nanocarriers can potentially augment the effectiveness of various therapies

MOESM3 of Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

Additional file 3. Wound-healing assay in MKN-45 and SGC-7901 cell lines. MKN-45 and SGC-7901 cells were co-cultured with GCAFs or CM from GCAFs for 72 hours before the wounds were generated. And the scratch area after 48 hours was measured to evaluate the migration abilities of cancer cells (scale bar=500 Âľm)

MOESM1 of Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

Additional file 1. Information data of the cases enrolled in this study. This file includes the clinicopathological information of cases enrolled in this study

MOESM2 of Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer

Additional file 2. Correlations between FAP staining and the clinicopathology of gastric cancer. The table in this file shows the correlations between FAP staining in GCAFs and the clinicopathology of gastric cancer